Possible role of aminoacyl-RNA complexes in noncoded peptide synthesis and origin of coded synthesis.

Schimmel, Paul; Henderson, Barry

doi:10.1073/pnas.91.24.11283

Cited by 67 publications

(55 citation statements)

References 34 publications

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“…How the coding of amino acids by specific nucleotide sequences emerged is harder to imagine. An interesting proposal has been put forth by Schimmel and coworkers (Schimmel and Henderson 1994), involving an intermediate stage of side-by-side interactions between adjacent amino acid-specific proto-tRNAs, whose identity elements were contained exclusively in their acceptor stems. This system of noncoded peptide synthesis would then be converted to a system for template-directed synthesis.…”

Section: Discussionmentioning

confidence: 99%

Evolution of Protein Synthesis from an RNA World

Noller¹

2010

Cold Spring Harbor Perspectives in Biology

126

114

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SUMMARYBecause of the molecular complexity of the ribosome and protein synthesis, it is a challenge to imagine how translation could have evolved from a primitive RNA World. Two specific suggestions are made here to help to address this, involving separate evolution of the peptidyl transferase and decoding functions. First, it is proposed that translation originally arose not to synthesize functional proteins, but to provide simple ( perhaps random) peptides that bound to RNA, increasing its available structure space, and therefore its functional capabilities. Second, it is proposed that the decoding site of the ribosome evolved from a mechanism for duplication of RNA. This process involved homodimeric "duplicator RNAs," resembling the anticodon arms of tRNAs, which directed ligation of trinucleotides in response to an RNA template.

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Section: Discussionmentioning

confidence: 99%

Evolution of Protein Synthesis from an RNA World

Noller¹

2010

Cold Spring Harbor Perspectives in Biology

126

114

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“…The most popular model (Noller 1993;Weiner 1993 and1994;Schimmel et al 1993;Schimmel and Henderson 1994), envisions the tRNA as having two domains, each encompassing half the molecule. One domain contains the terminal CCA sequence to which the incoming amino acid or growing peptide is attached.…”

Section: Trna Origins and Increasing Rna Complexitymentioning

confidence: 99%

Origin and Evolution of the Ribosome

Fox¹

2010

Cold Spring Harbor Perspectives in Biology

212

186

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The modern ribosome was largely formed at the time of the last common ancestor, LUCA. Hence its earliest origins likely lie in the RNA world. Central to its development were RNAs that spawned the modern tRNAs and a symmetrical region deep within the large ribosomal RNA, (rRNA), where the peptidyl transferase reaction occurs. To understand pre-LUCA developments, it is argued that events that are coupled in time are especially useful if one can infer a likely order in which they occurred. Using such timing events, the relative age of various proteins and individual regions within the large rRNA are inferred. An examination of the properties of modern ribosomes strongly suggests that the initial peptides made by the primitive ribosomes were likely enriched for L-amino acids, but did not completely exclude D-amino acids. This has implications for the nature of peptides made by the first ribosomes. From the perspective of ribosome origins, the immediate question regarding coding is when did it arise rather than how did the assignments evolve. The modern ribosome is very dynamic with tRNAs moving in and out and the mRNA moving relative to the ribosome. These movements may have become possible as a result of the addition of a template to hold the tRNAs. That template would subsequently become the mRNA, thereby allowing the evolution of the code and making an RNA genome useful. Finally, a highly speculative timeline of major events in ribosome history is presented and possible future directions discussed.

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“…Specification of amino acids by RNA sequences most likely emerged later, requiring coevolution of the ribosome and its tRNAs (Noller 1993;Schimmel and Henderson 1994) ultimately leading to our present, protein-dominated form of biology. Most difficult to explain is this final phase of evolution of the ribosome, the emergence of coding, which gave rise to "one of the great evolutionary saltations…that would generate a truly enormous new, totally unique evolutionary phase space" (Woese 2004).…”

Section: Evolution Of Translationmentioning

confidence: 99%

The driving force for molecular evolution of translation

Noller¹

2004

RNA

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Possible role of aminoacyl-RNA complexes in noncoded peptide synthesis and origin of coded synthesis.

Cited by 67 publications

References 34 publications

Evolution of Protein Synthesis from an RNA World

Evolution of Protein Synthesis from an RNA World

Origin and Evolution of the Ribosome

The driving force for molecular evolution of translation

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