Possible role of ALDH1 and CD44 in lip carcinogenesis
Rafael Carneiro ORTIZ,
Gabriele Gomes GOIS,
Camila Alves COSTA
et al.
Abstract:Possible role of ALDH1 and CD44 in lip carcinogenesisLip squamous cell carcinoma (LSCC) accounts for 12% of all head and neck cancers. It is caused by chronic exposure to ultraviolet light solar radiation and related to previous actinic cheilitis (AC). This study aimed to investigate the immunostaining of the putative cancer stem cells (CSC) markers ALDH1 and CD44 in AC (n=30) and LSCC (n=20). ALDH1 positivity was found to be statistically higher in LSCC than in AC lesions (p=0.0045), whilst CD44 expression wa… Show more
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