Possible reversibility of structural changes in renal vascular bed after correction of experimental coarctation of the aorta

Abstract

Renal vessels were studied in 22 puppies with induced coarctation of the aorta, 15 with corrected defect, and 12 controls by functional, histological, and morphometrical methods. Constriction of the isthmus of the aorta was associated with decreased pressure of blood flowing to the kidneys and pronounced morphological restructuring of the renal blood system components. Correction of the experimental defect triggers the mechanism of regression of previously induced changes and promotes appreciable recovery of the structure of renal arteries, veins, and glomeruli.