2021
DOI: 10.1080/13510002.2021.1971363
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Possible relationship between mitochondrial changes and oxidative stress under low dose-rate irradiation

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Cited by 22 publications
(19 citation statements)
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“…The dose‐rate was set close to the lower limit of the intermediate range (1 mGy/min) so that we could examine whether the novel method is suitable for analyzing the biological effect of relatively low dose‐rate irradiation. A previous study has shown that, under the same irradiation conditions, ROS staining by 2′,7′‐dichlorofluorescein diacetate (DCFH‐A) detected an increase of ~20% in ROS generation in 48BRhTERT cells (Meng et al, 2021). The same study suggested that DNA double‐strand breaks occurred at a much‐reduced rate compared with that in cells irradiated with the same dose at a higher dose‐rate (0.9 Gy/min).…”
Section: Introductionmentioning
confidence: 99%
“…The dose‐rate was set close to the lower limit of the intermediate range (1 mGy/min) so that we could examine whether the novel method is suitable for analyzing the biological effect of relatively low dose‐rate irradiation. A previous study has shown that, under the same irradiation conditions, ROS staining by 2′,7′‐dichlorofluorescein diacetate (DCFH‐A) detected an increase of ~20% in ROS generation in 48BRhTERT cells (Meng et al, 2021). The same study suggested that DNA double‐strand breaks occurred at a much‐reduced rate compared with that in cells irradiated with the same dose at a higher dose‐rate (0.9 Gy/min).…”
Section: Introductionmentioning
confidence: 99%
“…When IR interacts with organisms, it may directly or indirectly cause DNA lesions. The direct interaction is caused by ions hitting on DNA molecules, while the indirect effect is caused by reactive oxygen species (ROS) aggregation through the radiolysis of water ( van de Walle et al, 2016 ; Gudkov et al, 2019 ; Choi et al, 2021 ; Meng et al, 2021 ). ROS can diffuse through the cells and damage their components, but they are also important signaling molecules in plants responses to stresses, triggering related response mechanisms ( Volkova et al, 2019 ).…”
Section: Introductionmentioning
confidence: 99%
“…[8] They are essential for normal physiological functions, but excess ROS leads to oxidative stress causing cell injury and even cell death. [9] Recent evidence has demonstrated that mitochondrial dynamics are tightly coupled to ROS generation. [10] Aberrant mitochondrial morphology may lead to ROS overaccumulation, which in turn, may cause mitochondrial damage and disruption of mitochondrial dynamics.…”
Section: Introductionmentioning
confidence: 99%
“…Reactive oxygen species (ROS), mainly generated as a by‐product of mitochondrial respiration or metabolism, play a role in both cell progression and survival [8] . They are essential for normal physiological functions, but excess ROS leads to oxidative stress causing cell injury and even cell death [9] . Recent evidence has demonstrated that mitochondrial dynamics are tightly coupled to ROS generation [10] .…”
Section: Introductionmentioning
confidence: 99%