Possible Relation between Vitamin D and Interleukin-17 in the Pathogenesis of Lichen Planus

Mahmoud, Sara; Anwar, M.; Shaker, Olfat; Sharkawy, Dina Ahmed El

doi:10.1159/000510539

Cited by 7 publications

(8 citation statements)

References 18 publications

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“…We identified 22 eligible studies that involved 672 OLP patients and 378 healthy controls 16–37 . All studies were case–control designed as illustrated in detail in Table 1.…”

Section: Resultsmentioning

confidence: 99%

Potential role of INTERLEUKIN‐17 in the pathogenesis of oral lichen planus: a systematic review with META‐analysis

Husein‐ElAhmed

Steinhoff

2022

Acad Dermatol Venereol

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Oral lichen planus (OLP) is a chronic inflammatory mucocutaneous disease of unknown aetiology, which may evolve into squamous cell carcinoma. Recent advances on OLP pathogenesis suggest the presence of Th17 cells and the upregulation of interleukin-17 (IL-17) expression are crucial events. Our aim was to test the hypothesis in the literature about an important role of IL-17 in OLP by systematically investigating the overexpression of IL-17 in the lesional tissue and blood from OLP patients and healthy controls. A total of 22 studies comprising 658 OLP patients and 362 control subjects fulfilled inclusion criteria were subjected to meta-analysis. The assessment of IL-17 in the lesional tissue by quantitative real-time polymerase chain reaction (PCR) revealed a significant elevation in the OLP group (RR:1.35 95% CI: 0.20-2.50, I 2 = 92%). There was a statistical overexpression of IL-17 in the serum of OLP group detected by ELISA (RR:2.47 95%CI: 1.17-3.77, I 2 = 97%) and flow cytometry (RR:3.04 95%CI: 0.69-5.39, I 2 = 97%). In the erosive OLP group, the tissue IL-17 assessed by PCR was higher than in reticular OLP patients (RR:0.78 95%CI: 0.21-1.36, I 2 = 0%).Peripheral assessment of IL-17 by ELISA (RR:1.43 95%CI: 0.01-2.85, I 2 = 94%) and flow cytometry (RR:1.55 95%CI: 0.29-2.81, I 2 = 89%) revealed significant elevation in erosive OLP group. The dominating overexpression of IL-17 and Th17 cells in the local inflammatory inf ıltrate and serum of OLP patients confirms its role, probably in the interaction between T cells and keratinocytes. Notably, the upregulation of IL-17 is more intense in erosive than in reticular OLP suggesting a positive correlation between IL-17 levels and disease severity. Further research is warranted to investigate the potential role of anti-IL-17 drugs to manage this chronic condition.

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“…We identified 22 eligible studies that involved 672 OLP patients and 378 healthy controls 16–37 . All studies were case–control designed as illustrated in detail in Table 1.…”

Section: Resultsmentioning

confidence: 99%

Potential role of INTERLEUKIN‐17 in the pathogenesis of oral lichen planus: a systematic review with META‐analysis

Husein‐ElAhmed

Steinhoff

2022

Acad Dermatol Venereol

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“…Interestingly, recent researches have suggested the potential role of vitamin D in reducing the expression of some pro-inflammatory cytokines [ 40 ]. Specifically, vitamin D deficiency has been correlated to higher serum levels of IL-17 and IL-6 in OLP patients, especially in the symptomatic subset [ 41 ].…”

Section: Discussionmentioning

confidence: 99%

Anxiety and depression in keratotic oral lichen planus: a multicentric study from the SIPMO

et al. 2023

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Objectives Oral lichen planus with exclusive keratotic reticular, papular, and/or plaque-like lesions (K-OLP) is a clinical pattern of OLP that may be associated with a complex symptomatology and psychological alteration. The aim of the study was to evaluate the prevalence of anxiety (A) and depression (D) in patients with K-OLP, analyzing the potential predictors which can affect mental health status. Methods Three hundred K-OLP patients versus 300 healthy controls (HC) were recruited in 15 Italian universities. The Numeric Rating Scale (NRS), Total Pain Rating Index (T-PRI), and Hamilton Rating Scales for Depression and for Anxiety (HAM-D and HAM-A) were administered. Results The K-OLP patients showed statistically higher scores in the NRS, T-PRI, HAM-D, and HAM-A compared with the HC (p-value < 0.001**). A and D were found in 158 (52.7%) and 148 (49.3%) K-OLP patients. Strong linear correlations were identified between HAM-A, HAM-D, NRS, T-PRI, and employment status and between HAM-D, HAM-A, NRS, T-PRI, employment status, and female gender. Multivariate logistic regression revealed that HAM-D and HAM-A showed the greatest increase in the R2 value for A and D in the K-OLP patients, respectively (DR2 = 55.5% p-value < 0.001**; DR2 = 56.5% p-value < 0.001**). Conclusions The prevalence of A and D is higher in the K-OLP patients compared with the HC, also found in K-OLP subjects without pain, suggesting that the processing of pain may be in a certain way independent of the processing of mood. Clinical relevance Mood disorders and pain assessment should be carefully performed in relation to K-OLP to obtain a complete analysis of the patients.

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“…IL-17 may further result in diminished oral bacterial heterogeneity, causing the triggering of the innate and adaptive immune response, eventually resulting in disease exacerbation. Vitamin D exerts an inhibitory effect on T-helper 17 activity by direct transcriptional inhibition of IL-17 gene expression [ 57 ].…”

Section: Discussionmentioning

confidence: 99%

Vitamin D in the Treatment of Oral Lichen Planus: A Systematic Review

Saeed

Choudhury²,

Ahmad

et al. 2022

Biomedicines

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Oral lichen planus (OLP) is a chronic mucocutaneous condition that affects up to 2% of the general population, and typically presents with long-standing, non-responsive lesions, with episodes of exacerbation and remissions. The etiopathogenesis of OLP is still unclear, although, it has been postulated that it is most likely a T-cell-mediated condition of an unknown antigen. The treatment remains a challenge with no defined treatment strategy. Vitamin D has anti-inflammatory and immunomodulatory properties, along with its regulatory effect on keratinocyte proliferation and differentiation; thus, suggesting its possible role in the treatment of OLP. This systematic review aims to evaluate the therapeutic role of vitamin D in OLP treatment. We searched PubMed/MEDLINE, and Google scholar search engines for studies evaluating vitamin D as a treatment modality in OLP from January 2000 to August 2022. Articles were searched with the combination of Medical Subject Heading (MeSH) terms. A web platform for visualizing risk-of-bias assessment was used in this review, and descriptive statistics were calculated. Out of the seventeen retrieved studies, five articles meeting the inclusion criteria were considered in this systematic review. All the included studies demonstrated significant amelioration in the OLP symptoms in patients who were given vitamin D supplements as an adjuvant to the conventional steroid therapy and or placebo. This systematic review signifies the role of vitamin D as adjuvant therapy for OLP. However, more studies with larger sample size are required to validate these results.

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Possible Relation between Vitamin D and Interleukin-17 in the Pathogenesis of Lichen Planus

Cited by 7 publications

References 18 publications

Potential role of INTERLEUKIN‐17 in the pathogenesis of oral lichen planus: a systematic review with META‐analysis

Potential role of INTERLEUKIN‐17 in the pathogenesis of oral lichen planus: a systematic review with META‐analysis

Anxiety and depression in keratotic oral lichen planus: a multicentric study from the SIPMO

Vitamin D in the Treatment of Oral Lichen Planus: A Systematic Review

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