Possible protective effects of quercetin on doxorubicin-induced cardiotoxicity in rats

Hashish, Fatma E. R.; Abdelwahed, Moshira; El-Odemi, Mahmoud H; El-Naidany, Sherin Sobhy; ElBatsh, Maha M.

doi:10.4103/mmj.mmj_5_20

Cited by 9 publications

(6 citation statements)

References 1 publication

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“…36 The presented study showed that Dox could decrease the antioxidant biomarker T-AOC in consistent with a previous study. 37 T-AOC marker takes into account the synergistic effects of all antioxidants found in biological fluids, resulting in an integrative system of these molecules. When compared to the activity of a single antioxidant, T-AOC has the better predictive ability and biological significance.…”

Section: Discussionmentioning

confidence: 99%

Role of Gender in the Protection Against Doxorubicin-Induced Oxidative Stress

Hammo¹,

Ahmad²,

Althanoon³

2023

Pharmacogn J.

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Background: There are gender differences in the oxidation-reduction reactions. Doxorubicin (Dox) is a chemotherapeutic drug that can produce oxidative stress which may require prevention by antioxidants. Aim: The study aimed to investigate the gender-dependent changes in Dox-induced oxidative stress, and the protective effects of coenzyme Q10 (CoQ10). Materials and Methods: Rats were administered CoQ10 orally for 17 days. On day 13, some rats receiving CoQ10 received a single intraperitoneal dosage of Dox, whereas other rats received normal saline. Glutathione (GSH), malondialdehyde (MDA), and total anti-oxidant capacity (T-AOC) were measured in both genders of albino rats. Results: Dox significantly reduced both GSH and T-AOC levels and caused a significant increase in MDA. The administration of CoQ10 significantly prevented these changes. Dox caused a larger reduction in GSH in males than in females, while CoQ10 caused more protection in females. Dox caused a higher increase in MDA levels in males. Conclusion: Pre-treatments with CoQ10 may protect against Dox-induced oxidative stress, with gender-dependent variations in the extent of these Dox/CoQ10 effects.

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Section: Discussionmentioning

confidence: 99%

Role of Gender in the Protection Against Doxorubicin-Induced Oxidative Stress

Hammo¹,

Ahmad²,

Althanoon³

2023

Pharmacogn J.

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“…This effect could be explained by the richness of F. officinalis in quercetin, which stimulates appetite [47] and reduced the weight loss. [48] The liver is considered as a target organ which transforms, accumulates metabolite, neutralizes, and eliminates countless toxic substances in blood. [49] Moreover, previous investigations have revealed that exposure to permethrin is able to induce histopathological, biochemical, and physiological perturbations in liver tissue.…”

Section: Discussionmentioning

confidence: 99%

The pyrethroid insecticide permethrin confers hepatotoxicity through DNA damage and mitochondria‐associated apoptosis induction in rat: Palliative benefits of Fumaria officinalis

Aoiadni

Chiab

Jdidi

et al. 2022

J Biochem & Molecular Tox

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Permethrin (PER) is a pyrethroid pesticide that is extensively used as an insecticide in world because of its high activity and its low mammalian toxicity. The current study was conducted to investigate the protective action of Fumaria officinalis against PER‐induced liver injury in male rats. However, HPLC‐DAD showed the richness of 6 components in F. officinalis (F) including quercetin, ferulic acid, and naringenin which were the most abundant. Total polyphenols, total flavonoids, and condensed tannins were studied by phytochemical screening. In vitro, antioxidant properties showed that F. officinalis exhibited the highest DPPH radical, FRAP, and H2O2 tests and total antioxidant capacity. Wistar rats were divided into four groups: negative control group (C), positive control group (F) (200 mg F. officinalis/kg BW), PER group (34.05 mg permethrin/kg BW), and PER + F group (34.05 mg permethrin/kg BW and 200 mg F. officinalis/kg BW). Oral administration of PER led to promote a decrease of body weight and Ca2+‐ATPases and Mg2+‐ATPases activities and an increase of plasma C‐reactive protein level, transaminases, and hepatic ϒ‐GT activities as well as hepatic and mitochondrial oxidative stress. An increase in plasma lactate‐to pyruvate ratio and a reduction in complexes enzymes I, III, and IV activities were also observed. In addition, histoarchitecture of liver in PER‐treated rats showed apoptosis and necrosis as confirmed by DNA fragmentation. F. officinalis significantly exerted hepatoprotective effect by modulating hepatic alteration and mitochondrial dysfunction as well as genotoxicity. This effect could be attributed to phenolics compounds such as polyphenols, condensed tannins, and flavonoids.

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“…Additionally, QU greedily scavenges superoxide anion, lipid proxy radicals, and singlet oxygen (Nathiya et al 2014). Further, it inhibits the activation of extracellular signal-regulated kinase and mitogen-activated protein kinase in ROS-mediated cardiomyopathy (Hashish et al 2021). Also, QU was a robust agent versus cardiac ischemia-reperfusion injury, diabetic cardiomyopathy, and cardiotoxicity, indicating cardioprotective effects (Ertuğ et al 2013).…”

Section: Introductionmentioning

confidence: 97%

“…The essential reason for DOX-induced cardiac toxicity is the production of reactive oxygen species (ROS), in addition to mitochondrial dysfunction (Pereira, et al 2011). Since cardiomyocytes have relatively low levels of antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), Glutathione-S-transferase, and glucose-6-phosphatedehydrogenase (Hashish et al 2021;do Nascimento, T.C.,, et al 2020;Doroshow et al 1980), they are more vulnerable to free radical-mediated damage induced by DOX. The implication of SOD in cardiovascular diseases has been described.…”

Section: Introductionmentioning

confidence: 99%

Optimized synthesis characterization and protective activity of quercetin and quercetin–chitosan nanoformula against cardiotoxicity that was induced in male Wister rats via anticancer agent: doxorubicin

Soliman

Mahmoud²,

Eldin³

et al. 2023

Cancer Nano

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The study’s goal was to look into the protective properties of quercetin (QU) in natural form and QU nanoparticles-loaded chitosan nanoparticles (QU-CHSNPs) against cardiotoxicity. The ionotropic gelation approach was adopted to form QU-CHSNPs. The characterizations were performed using advanced techniques. In vitro, the release profile of QU was studied. Cardiotoxicity was induced by doxorubicin (DOX) and protected via concurrent administration of QU and QU-CHSNPs. The heart's preventive effects of QU and QU-CHSNPs were manifested by a decrease in elevated serum activities of cardiac enzymes, as well as an improvement in the heart's antioxidant defence system and histological changes. The findings substantiated QU-CHSNPs' structure with an entrapment efficiency of 92.56%. The mean of the zeta size distribution was 150 nm, the real average particle size was 50 nm, and the zeta potential value was − 27.9 mV, exhibiting low physical stability. The percent of the free QU-cumulative release was about 70% after 12 h, and QU-CHSNPs showed a 49% continued release with a pattern of sustained release, reaching 98% after 48 h. And as such, QU and QU-CHSNPs restrained the induced cardiotoxicity of DOX in male Wistar rats, with the QU-CHSNPs being more efficient.

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Possible protective effects of quercetin on doxorubicin-induced cardiotoxicity in rats

Cited by 9 publications

References 1 publication

Role of Gender in the Protection Against Doxorubicin-Induced Oxidative Stress

Role of Gender in the Protection Against Doxorubicin-Induced Oxidative Stress

The pyrethroid insecticide permethrin confers hepatotoxicity through DNA damage and mitochondria‐associated apoptosis induction in rat: Palliative benefits of Fumaria officinalis

Optimized synthesis characterization and protective activity of quercetin and quercetin–chitosan nanoformula against cardiotoxicity that was induced in male Wister rats via anticancer agent: doxorubicin

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