Possible Protective Effect of 5-Aminosalicylic Acid on Helicobacter pylori Infection in Patients With Inflammatory Bowel Disease

Piodi, L.; Bardella, Maria Teresa; Rocchia, Cristina; Cesana, Bruno Mario; Baldassarri, A.; Quatrini, M

doi:10.1097/00004836-200301000-00008

Cited by 36 publications

(34 citation statements)

References 18 publications

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“…The prevalence of this bacterial infection is lower in CD compared to UC, in the majority of these studies. Potential confounders include the effect of salazopyrine, other 5-ASA compounds, and antibiotics on the carriage and eradication of H pylori [26,27] . However, neither salazopyrine nor the other 5-ASA dr ugs used in IBD reach the concentrations required in the corpus and antrum of the stomach to effect H pylori eradication.…”

Section: H Pylori Exposurementioning

confidence: 99%

Hygiene hypothesis in inflammatory bowel disease: A critical review of the literature

Koloski¹,

Bret²,

Radford‐Smith³

2008

WJG

189

117

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The hygiene hypothesis is thought to be a significant contributor to the growing incidence of inflammatory bowel disease (IBD) around the world, although the evidence for specific factors that underlie the hygiene hypothesis in IBD is unclear. We aimed to systematically review the literature to determine which hygiene-related factors are associated with the development of IBD. Publications identified from a broad based MEDLINE and Current Contents search between 1966 and 2007 on key terms relevant to the 'hygiene hypothesis' and IBD including H pylori exposure, helminths, cold chain hypothesis, measles infection and vaccination, antibiotic use, breastfeeding, family size, sibship, urban upbringing, day care attendance and domestic hygiene were reviewed. The literature suggests that the hygiene hypothesis and its association with decreased microbial exposure in childhood probably plays an important role in the development of IBD, although the strength of the supporting data for each of the factors varies considerably. The most promising factors that may potentially be associated with development of IBD include H pylori exposure, helminths, breastfeeding and sibship. However, the vast majority of studies in this area are plagued by serious methodological shortcomings, particularly the reliance on retrospective recall of information making it difficult to truly ascertain the importance of a 'hygiene hypothesis' in IBD. The 'hygiene hypothesis' in IBD is an important area of research that may give clues to the aetiology of this disease. Directions for future research are recommended.

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Section: H Pylori Exposurementioning

confidence: 99%

Hygiene hypothesis in inflammatory bowel disease: A critical review of the literature

Koloski¹,

Bret²,

Radford‐Smith³

2008

WJG

189

117

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“…Some researchers reported that incidence of H. pylori is lower in UC patients than in healthy populations (9)(10)(11)(12). Possible causes of this low rate of H. pylori in UC patients are the immunopathological characteristics of UC and the medications used in UC, such as 5-aminosalicylic acid (5-ASA) and antibiotics (9)(10)(11)(12). We investigated the incidence of H. pylori in individuals with UC and determined the impact of several characteristics of UC, including extent and severity of UC, on the incidence of H. pylori.…”

Section: Introductionmentioning

confidence: 99%

The relation between Helicobacter pylori and ulcerative colitis

Caner¹,

Altınbaş²,

Yeşil³

et al. 2014

Turk J Med Sci

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IntroductionUlcerative colitis (UC), characterized by permanent mucosal inflammatory processes, presents with remission and activating periods (1). Although some environmental and genetic causes are attributed to UC progression, the exact cause of the disease is still unclear (1,2). In the recent years, investigators have focused on some pathogens as causes of UC (3,4).Helicobacter pylori, a pathogen related to chronic gastritis and peptic ulcers, is colonized mainly in the antrum, protecting itself from hyperacidity (5,6). Almost half of the underdeveloped populations are infected by H. pylori. Apart from the gastrointestinal system disorders, H. pylori is also found to be related to several skin diseases, autoimmune disorders, and iron deficiency (7,8). The association between H. pylori and UC is controversial. Some researchers reported that incidence of H. pylori is lower in UC patients than in healthy populations (9-12). Possible causes of this low rate of H. pylori in UC patients are the immunopathological characteristics of UC and the medications used in UC, such as 5-aminosalicylic acid (5-ASA) and antibiotics (9-12).We investigated the incidence of H. pylori in individuals with UC and determined the impact of several characteristics of UC, including extent and severity of UC, on the incidence of H. pylori. Materials and methodsPatients who were diagnosed with colitis and admitted to the outpatient gastroenterology clinic of Numune Training and Research Hospital were included in the study. Specifically, 49 patients with UC who had undergone upper gastrointestinal endoscopy with various indications were included in the study. The presence of H. pylori was assessed by taking one biopsy from the antrum in each patient. Patients using antacids or antibiotics in the previous 2 months or who had previously undergone H. pylori eradication treatment were excluded from the study. Prior to the study, all UC patients were required to provide an informed consent form and the study design was submitted to local ethics committee for approval.The density of the colonization of H. pylori was assessed by using Sydney classification (13). The demographic data of the patients in each group were obtained from the Background/aim: Besides some genetic explanations of the native course of ulcerative colitis (UC), the most attributable factors are pathogenic bacterial agents. There are some conflicting data about the relationship between Helicobacter pylori and the rate of UC in the literature. Therefore, we aimed to investigate the rate of H. pylori in UC patients.Materials and methods: Forty-nine individuals diagnosed with UC who had undergone upper gastrointestinal tract endoscopy for different reasons were included in the study. The presence of H. pylori in the stomach was checked by histopathological examination.Results: H. pylori positivity was present in 57.1% of patients with UC. Interestingly, H. pylori positivity was lower (11.1%) in pancolitis patients compared to those presenting with more limited illnesses. There wer...

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“…Several of these later studies further substituted H. pylori serum IgG or IgA serology for the C 13 urea breath test, an accurate test for assessing active (as opposed to past) infection. These studies also unequivocally confirmed a lower prevalence of H. pylori in IBD patients [66,67,68]. Although all early studies were conducted on European populations, in which IBDs are much more common than in other geographical areas of the world, several more recent studies have confirmed the same trends in Asian and American populations [69,70,71].…”

Section: Epidemiological Evidence Suggests An Inverse Association Betmentioning

confidence: 74%

<b><i>Helicobacter pylori</i></b>: Does Gastritis Prevent Colitis?

Arnold¹,

Müller²

2016

Inflamm Intest Dis

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Background: Since its discovery in the early 1980s, Helicobacter pylori has been linked to a variety of gastric and extragastric diseases. Chronic infection with H. pylori causes histologically evident gastritis in all colonized individuals and is the predominant risk factor for gastric and duodenal ulcers as well as gastric adenocarcinoma. However, increasingly robust experimental and epidemiological evidence suggests that H. pylori may at the same time be beneficial to its carriers, as it efficiently prevents allergic disorders and chronic inflammatory conditions. The purpose of this review is to summarize and document the latest evidence for a possible inverse association of H. pylori infection status and the risk of inflammatory bowel disease (IBD), as provided in both experimental and human observational studies. The pathogenesis of IBDs, the available mouse models for these diseases and the dual role of H. pylori in health and disease are presented in dedicated chapters. Summary and Key Messages: Almost all available epidemiological data suggest that H. pylori infection is inversely associated with both Crohn's disease (CD) and ulcerative colitis in European, Asian as well as American populations; large meta-analyses reviewing 30 original articles or more document that this inverse association is especially strong in CD patients and in children and young adults. Experimental data available from various mouse models of IBD confirm that live H. pylori infection as well as treatment with immunomodulatory molecules of H. pylori reduce clinical and histopathological IBD symptoms. Various proposed mechanisms involving the tolerization of dendritic cells, the production of protective cytokines and the preferential induction and differentiation of regulatory T-cells are presented. The implications of the beneficial aspects of the Helicobacter-host interaction for H. pylori eradication decisions, as well as potential new therapeutic options in the treatment of IBD are discussed in this review.

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Possible Protective Effect of 5-Aminosalicylic Acid on Helicobacter pylori Infection in Patients With Inflammatory Bowel Disease

Abstract: Although low, the prevalence of Hp infection in our patients was not significantly different from that in the controls. 5-ASA, and not sulfasalazine, may have a protective effect against Hp infection.

Cited by 36 publications

References 18 publications

Hygiene hypothesis in inflammatory bowel disease: A critical review of the literature

Hygiene hypothesis in inflammatory bowel disease: A critical review of the literature

The relation between Helicobacter pylori and ulcerative colitis

<b><i>Helicobacter pylori</i></b>: Does Gastritis Prevent Colitis?

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