Possible Neuroprotective Properties of Flunarizine Infused after Asphyxia in Fetal Lambs Are Not Explained by Effects on Cerebral Blood Flow or Systemic Blood Pressure

Haan, Harmen H. de; Reempts, J. L. H. Van; Borgers, M.; Haan, J. de; Vles, Johan S.H.; Hasaart, T. H. M.

doi:10.1203/00006450-199309000-00027

Cited by 10 publications

(1 citation statement)

References 27 publications

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“…It has been shown to protect against ischemia mediated neuronal dysfunction (De Haan et al 1993;Gunn et al 1994). Paradoxically, the same drugs have been implicated in the induction of Parkinson's disease (Veich and Hue 1994;Negrotti and Calzetti 1997).…”

Section: Introductionmentioning

confidence: 97%

Ameliorative effect of flunarizine in cisplatin-induced acute renal failure via mitochondrial permeability transition pore inactivation in rats

Muthuraman

Sood

Singla

et al. 2010

Naunyn-Schmied Arch Pharmacol

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This study was aimed to evaluate the protective effect of flunarizine on cisplatin-induced acute renal failure. Administration of cisplatin (6 mg/kg, i.p. on day 6) significantly increased serum blood urea nitrogen and creatinine, urinary N-acetyl β-D-glucosaminidase, tissue thiobarbituric acid reactive substances and total calcium whereas, decreased body weight, fractional excretion of sodium, creatinine clearance tissue-reduced glutathione, mitochondrial cytochrome c oxidase, and ATP levels were observed in acute renal failure rats. Moreover, cisplatin produced histopathological changes in the renal tissue. Furthermore, flunarizine (100, 200, and 300 μM/kg, p.o., for six consecutive days) was administered to evaluate its therapeutic potential in acute renal failure, and the results were compared with cyclosporin A (50 μM/kg, p.o., for six consecutive days) as a reference drug. Flunarizine resulted in the attenuation of cisplatin-induced renal dysfunction, oxidative stress marker, mitochondrial damage, and histopathological changes in rats. Medium and higher doses of flunarizine produced significant renal protective effect which was comparable to cyclosporin A. The results of this study clearly revealed that flunarizine protected the kidney against the nephrotoxic effect of cisplatin via mitochondrial permeability transition pore inactivation potential.

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Section: Introductionmentioning

confidence: 97%