2020
DOI: 10.3390/ijms21165895
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Possible Neuroprotective Mechanisms of Physical Exercise in Neurodegeneration

Abstract: Physical exercise (PE) improves physical performance, mental status, general health, and well-being. It does so by affecting many mechanisms at the cellular and molecular level. PE is beneficial for people suffering from neuro-degenerative diseases because it improves the production of neurotrophic factors, neurotransmitters, and hormones. PE promotes neuronal survival and neuroplasticity and also optimizes neuroendocrine and physiological responses to psychosocial and physical stress. PE sensitizes the parasy… Show more

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Cited by 163 publications
(113 citation statements)
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“…It is for these patterns in changes according to genotype, age and exercise that we have chosen the tibialis anterior muscle to measure the expression of COL1A1 and MT-CO1; which allowed us to make a correlation between the genotype-dependent changes in muscle weight and power and the corresponding changes in the expression of these two proteins, depending on SPARC expression. Additionally, the decrease in brain weight percentage with ageing correlates with age-related neurodegeneration and related diseases [87,88], which are improved by exercise [89][90][91] and that, also, correlate with our data, showing an increase (trend) in the brain weight percentage with exercise.…”
Section: Body and Tissue Weights (Table 3)supporting
confidence: 89%
“…It is for these patterns in changes according to genotype, age and exercise that we have chosen the tibialis anterior muscle to measure the expression of COL1A1 and MT-CO1; which allowed us to make a correlation between the genotype-dependent changes in muscle weight and power and the corresponding changes in the expression of these two proteins, depending on SPARC expression. Additionally, the decrease in brain weight percentage with ageing correlates with age-related neurodegeneration and related diseases [87,88], which are improved by exercise [89][90][91] and that, also, correlate with our data, showing an increase (trend) in the brain weight percentage with exercise.…”
Section: Body and Tissue Weights (Table 3)supporting
confidence: 89%
“…Physical exercise affects many mechanisms at the cellular and molecular levels. It improves the production of neurotrophic factors, neurotransmitters, and hormones and promotes neuronal survival and neuroplasticity (Mahalakshmi et al, 2020). However, evidence that short-term, singlecomponent exercise interventions promote cognitive function and prevent cognitive decline or dementia in older adults is largely insufficient (Brasure et al, 2018).…”
Section: Role Of Non-pharmacological Interventionsmentioning
confidence: 99%
“…For instance, the neuroprotective mechanism of flavonoids, is thought to proceed via multiple mechanisms including suppression of lipid peroxidation, inhibition of inflammatory mediators, modulation of gene expressions and improvement of the activity of antioxidant enzymes [ 18 ]. Combined with regular physical exercise [ 20 ], increasing the intake of fruits containing bioactive antioxidants is suggested to delay or inhibit neurodegeneration and correlated diseases [ 21 ].…”
Section: Introductionmentioning
confidence: 99%