Possible Neurophysiological Markers of Genetic Predisposition to Alzheimer’s Disease

Ponomareva, Natalia; Фокин, В. Ф.; Selesneva, N.D.; Voskresenskaia, N I

doi:10.1159/000017071

Cited by 31 publications

(9 citation statements)

References 11 publications

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“…Furthermore, the P2 latency S.D. of the young healthy subjects used in this study is comparable to that of elderly healthy subjects in other published studies in the AD literature (e.g., Coburn et al, 1991;Moore et al, 1995;Ponomareva et al, 1998). It appears therefore that the S.D.…”

Section: Implications For Ad Diagnosissupporting

confidence: 85%

Effects of flash mode and intensity on P2 component latency and amplitude

Coburn

Amoss

Arruda

et al. 2005

International Journal of Psychophysiology

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Section: Implications For Ad Diagnosissupporting

confidence: 85%

Effects of flash mode and intensity on P2 component latency and amplitude

Coburn

Amoss

Arruda

et al. 2005

International Journal of Psychophysiology

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“…In this study, the latency of P2 and the later peaks were significantly delayed, and the amplitudes of N2-P2 and P2-N3 were decreased with age advanced. The flash VEP was demonstrated to be a specific indicator of dementia in human, particularly on the latency of P2 [4,18,22], since no P2 latency delayed was detected in the patient with depres-sion, confusion, and/or forgetfulness [15,18,22]. In addition, the amplitude of flash VEP showed more commonly in aged human [3,23], like as shown in N2-P2 and P2-N3 of aged dogs in this study.…”

supporting

confidence: 55%

Age-Associated Changes of Flash Visual Evoked Potentials in Dogs

Kimotsuki¹,

Yasuda

Tamahara

et al. 2006

The Journal of Veterinary Medical Science

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ABSTRACT. Age-associated changes of visual evoked potentials by flash stimulation (flash VEP) were evaluated in 53 beagle dogs aged from 1-to 15-year-old. Among the components of flash VEP consisted of 3 positive (P1, P2 and P3) and 2 negative (N1 and N2) peaks by 150 msec, the latency of P2 and the later peaks (N2 and P3) were significantly delayed with aging. Both amplitudes of the P2-N2 and N2-P3 also showed a significant correlation with aging. The flash VEP is considered to be an available and useful technique to evaluate not only for visual pathway, but also some disturbance of neurological functions, like as those reported in demented human. KEY WORDS: age-associated change, canine, flash VEP.J. Vet. Med. Sci. 68(1): 79-82, 2006 Visual evoked potentials (VEPs) indicated electrophysiological responses from retina to visual cortex is reported to be an useful technique for evaluating optic pathway [8] and also to be a sensitive indicator for dementia in human [4,18,22]. Visser et al. [21] demonstrated that the latency of the flash VEP components was delayed in the patients with dementia, especially Alzheimer's disease. The latency of the positive peak 2 (P2 :mean latency was 100 msec) and the later components were significantly delayed, although the similar results were sometimes detected in aged human. The flash VEP recorded in dogs showed 3 positive (P1, P2 and P3) and 2 negative (N1 and N2) components by 150 msec after the flash stimuli, like as those reported in human [11,17,19]. In addition, various age-associated pathological and/or physiological changes were commonly observed in aged dogs as well as aged human [5,10]. Since there are few diagnostic techniques for dementia in dogs, age-associated changes of the flash VEP were evaluated using various aged beagle dogs.Total 53 beagle dogs (25 male and 28 female) aged from 1-to 15-year-old kept in Medical Safety Research Laboratories, Sankyo Co., Ltd., were used.The flash VEP was recorded using needle electrodes inserted in the midline of the scalp according to the method reported by Strain et al. [18]. Briefly, electrodes of recording, reference, and ground were placed over the midline of the nuchal crest, forehead, and vertex, respectively. Prior to recording, the dogs were instilled the mydriatic drug, including tropicamide and phenylephrine hydrochloride, and subcutaneously given atropine sulfate (0.05 mg/kg) and intramuscularly given xylazine (2-3 mg/kg) for the sedation. Then the dogs were dark-adapted at least 1 hr and the flash VEP were recorded in the dark shielded room. The white flash stimulus was given 1/sec with the intensity of 0.6 joule using a photostimulator (SLS-3100 Photostimulator, Nihon Kohden Co., Tokyo, Japan). The xenon lamp was located about 15 cm in front of the examined eye and another eye was covered with the black cloth. The responses were recorded with signal averager (Neuropack Four Mini, Nihon Kohden Co, Tokyo, Japan). The bandpass filter was set at 1 Hz low and 1,000 Hz high. In this study, consecutive 30 responses wer...

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“…The abnormal reactivity to afferent stimulation was also found in clinically healthy AD patients' relatives [9]. The increased amplitude of late components of visual evoked potentials was associated with the moderate delay of the late components' latencies.…”

Section: Discussionmentioning

confidence: 71%

“…an increase in the latencies and amplitudes of late components of visual evoked potentials; these features can be considered as signs of latent neurodegeneration in deep brain structures [9].…”

Section: Introductionmentioning

confidence: 99%

EEG Alterations in Subjects at High Familial Risk for Alzheimer’s Disease

2003

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Twenty first-order relatives of patients with early-onset Alzheimer’s disease (AD; mean age 43.7 ± 1.3 years), 20 patients with early-onset AD (mean age 65.7 ± 0.9 years) and age-matched normal controls for the relatives and the patients underwent quantitative EEG (qEEG) examinations. In AD patients, delta and theta relative power values were increased and alpha relative power was decreased compared with normal controls. The AD patients’ relatives had normal resting EEG parameters. Under hyperventilation in the AD relatives, synchronous high-voltage delta and theta activity and sharp waves were revealed, theta and delta relative powers were increased and alpha relative power was decreased compared with the resting EEG in the same persons. Moreover, under hyperventilation, the theta and delta relative powers in the EEG of the relatives were higher, and the alpha relative power was lower compared with the EEG of normal controls under the same conditions. It is suggested that the excitotoxic processes and oxidative stress underlie the EEG alterations in the AD patients’ relatives and that these alterations may be related to the further AD development.

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Possible Neurophysiological Markers of Genetic Predisposition to Alzheimer’s Disease

Cited by 31 publications

References 11 publications

Effects of flash mode and intensity on P2 component latency and amplitude

Effects of flash mode and intensity on P2 component latency and amplitude

Age-Associated Changes of Flash Visual Evoked Potentials in Dogs

EEG Alterations in Subjects at High Familial Risk for Alzheimer’s Disease

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