Possible Neonatal Herpes Simplex Virus (HSV) Acquired Postpartum from Maternal Oral HSV Reactivation after Neuraxial Morphine

Guzman, Miguel; Chawla, Rupesh; Duttchen, Kaylene

doi:10.1213/xaa.0000000000000013

Cited by 3 publications

(1 citation statement)

References 17 publications

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“…Most cases present with mild mucocutaneous symptoms. However, encephalitis and disseminated infection are rare, although possible, and associated with severe morbidity and mortality 7 18 19…”

Section: Pathophysiologymentioning

confidence: 99%

Pruritus, neuraxial morphine and recrudescence of oral herpes simplex and treatment: an educational review in obstetric patients

Putte

Jahr

Gieraerts

et al. 2022

Reg Anesth Pain Med

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Neuraxial opioids are well known to cause itching, which may be challenging to treat. Neuraxial morphine has been demonstrated to cause recrudescent herpes simplex viruses (HSV-1), especially in women during labor and childbirth with neuraxial analgesia, and may be an occult etiology of refractory itching. This educational review summaries the clinical and epidemiological characteristics associated with recrudescent HSV-1 in patients treated with neuraxial opioids, especially morphine

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Section: Pathophysiologymentioning

confidence: 99%

Pruritus, neuraxial morphine and recrudescence of oral herpes simplex and treatment: an educational review in obstetric patients

Putte

Jahr

Gieraerts

et al. 2022

Reg Anesth Pain Med

View full text Add to dashboard Cite

show abstract

Neonatal herpes: case series in two obstetric centres over a 10-year period (2013–2023), France

Bouthry,

Portet-Sulla,

Bouokazi

et al. 2024

Eur J Pediatr

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Morphine

2014

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S Morphine Oral herpes simplex virus reactivation in mother leading to oral herpes simplex virus infection in neonate: 2 case reportsA 37-year-old woman developed reactivation of oral herpes simplex virus (HSV) after receiving intrathecal morphine for caesarean delivery, and a 5-day-old male neonate who possibly acquired a localized oral HSV from his mother [not all outcomes stated].The mother had a history of oral HSV with recurrences approximately twice a year. She underwent elective caesarean delivery at 38 weeks of gestation. She was given intrathecal morphine 150µg along with spinal anaesthesia for caesarean delivery. There was no active oral HSV noted at birth. The mother and neonate were discharged 30 hours after the procedure. On the third day after delivery, the mother noted HSV lesions around her mouth area, and she also noted 4 lesions on her baby's lower lip on the fifth day after delivery.The mother took valaciclovir for her HSV lesions. The baby was brought to the hospital where he was found to have 4 vesicular ulcers on the left inner lip. The baby's oral lesions improved after 1 dose of acyclovir and were resolved after 1 week.Author comment: "This report describes a case of a 5-dayold neonate who possibly acquired a localized oral HSV from the mother who had oral HSV reactivation in association with neuraxial morphine." De Guzman MC, et al. Possible neonatal herpes simplex virus (HSV) acquired postpartum from maternal oral HSV reactivation after neuraxial morphine. A and A Case Reports 2: 103-105, No. 9, 01 May 2014. Available from: URL: http://

show abstract

Possible Neonatal Herpes Simplex Virus (HSV) Acquired Postpartum from Maternal Oral HSV Reactivation after Neuraxial Morphine

Cited by 3 publications

References 17 publications

Pruritus, neuraxial morphine and recrudescence of oral herpes simplex and treatment: an educational review in obstetric patients

Pruritus, neuraxial morphine and recrudescence of oral herpes simplex and treatment: an educational review in obstetric patients

Neonatal herpes: case series in two obstetric centres over a 10-year period (2013–2023), France

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