Possible Mechanisms for Impairments to Learning, Memory, and Attention due to Sleep Deprivation

Силькис, И. Г.

doi:10.1007/s11055-014-9954-x

Cited by 4 publications

(2 citation statements)

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“…Its key role in regulating sleep-wake behavior through cortical activation has also been identified (Lazarus et al, 2013). Hence, it has been hypothesized that sleep loss disrupts the homeostasis of dopamine and adenosine systems, and subsequently impairs the cortex-basal ganglia-thalamus-cortex circuit (Sil'kis, 2014). This can result in weakened attention and limited information processing, leading to impairments to cognitive and affective functions.…”

Section: Sleep Duration Cortico-basal Ganglia Connections and Early Adolescence Developmentmentioning

confidence: 99%

Long-lasting effects of insufficient sleep on neurocognitive development in early adolescence

Yang

Wang

2022

Preprint

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Importance: Adolescents nowadays often get insufficient sleep. Yet, the long-term adverse effects of sleep loss on developing brain and behavior remains unknown. Objective: To determine whether insufficient sleep leads to long-lasting impacts on mental health, cognition, and brain development in adolescents across two years. Design: This longitudinal study utilized a public dataset, the Adolescent Brain Cognitive Development (ABCD) study, which is an ongoing study starting from 2016. Setting: Data were collected from 21 research sites in the U.S. Participants: 11,875 9-10-year-olds were recruited using stratified sampling in order to reflect the diversity of the U.S. population. Intervention: Individuals with sufficient versus insufficient sleep (< 9 hours per day for adolescents) were compared after controlling for age (months), sex, race, puberty status, and other 7 covariates based on propensity score matching. Main Outcomes and Measures: Behavior problems, cognition, mental health assessments, resting-state functional connectivity, gray matter volume, cortical area, cortical thickness, and structural connectivity (Fractional anisotropy) were collected and preprocessed by the ABCD study. Independent-sample t-tests and meditation analysis were performed to investigate the effects of insufficient sleep. Results: 3021 matched pairs (50.7% male) were identified based on baseline assessment, with mean (SD) age of 119.5 (7.5) months. In baseline, sufficient sleep is associated less behavioral problems on 18 of 20 assessments, e.g. depress (95% CI of mean difference: -0.28 to -0.47, false discovery rate (FDR)-corrected p < .001, Cohen's d = -0.20), better cognitive performance on 7 of 10 assessments, such as crystal cognition (95% CI: 0.81 to 1.50, FDR-corrected p < .001, Cohen's d = 0.17), better functional connection between cortical regions and basal ganglia (all FDR-corrected p < .05, Cohen's d >0.15), and large structure in ACC and temporal pole (all FDR-corrected p < .05, Cohen's d >0.09). Similar patterns of effect of sufficient sleep were found in FL2 (749 pairs remained) e.g. Cohen's d of function connectivity at baseline was correlated with Cohen's d of that at FL2 (r = 0.54, 95% CI: 0.45 to 0.61, p < 1e-10). Mediation and longitudinal mediation analysis revealed that identified brain measures (e.g. gray matter volume of left temporal pole) at baseline mediated the effect of sufficient sleep on behavioral assessments (e.g. crystal cognition) at baseline and at FL2 (95% CI did not encompass 0, p < 0.05 on 100,000 random-generated bootstrapped samples). Conclusions and Relevance: These results provide strong population-level evidence for the long-lasting detrimental effects of insufficient sleep on mental health, cognition, and brain function and structure in adolescents. The current study identified potential neural mechanisms of adverse effect of insufficient sleep in adolescents, which might provide a theoretical grounding for sleep intervention programs to improve the long-term developmental outcomes in adolescents.

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Section: Sleep Duration Cortico-basal Ganglia Connections and Early Adolescence Developmentmentioning

confidence: 99%

Long-lasting effects of insufficient sleep on neurocognitive development in early adolescence

Yang

Wang

2022

Preprint

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“…As a general practice derived from clinical neuropsychology, researchers investigated sleep from the systematic study of its absence, i.e., by considering sleep deprivation. Indeed, sleep deprivation impairs cerebral functioning, thus producing (1) increasing difficulties in performing cognitive tasks that require concentration, (2) perceptual distortions and, in rare cases, (3) mild hallucinations (e.g., Babkoff et al, 1989;Petrovsky et al, 2014;Sil'kis, 2014;Waters et al, 2018). Most importantly, the effects of sleep disturbances intervene rapidly as even momentary sleep perturbations may impact the individuals' responsivity during the wake (e.g., Buzsáki and Watson, 2012).…”

Section: Introductionmentioning

confidence: 99%

Self-Reported Sleep Quality Across Age Modulates Resting-State Functional Connectivity in Limbic and Fronto-Temporo-Parietal Networks: An Exploratory Cross-Sectional fMRI Study

Federico

Alfano

Garramone

et al. 2022

Front. Aging Neurosci.

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Sleep problems are increasingly present in the general population at any age, and they are frequently concurrent with—or predictive of—memory disturbances, anxiety, and depression. In this exploratory cross-sectional study, 54 healthy participants recruited in Naples (Italy; 23 females; mean age = 37.1 years, range = 20–68) completed the Pittsburgh Sleep Quality Index (PSQI) and a neurocognitive assessment concerning both verbal and visuospatial working memory as well as subjective measures of anxiety and depression. Then, 3T fMRI images with structural and resting-state functional sequences were acquired. A whole-brain seed-to-seed functional connectivity (FC) analysis was conducted by contrasting good (PSQI score <5) vs. bad (PSQI score ≥5) sleepers. Results highlighted FC differences in limbic and fronto-temporo-parietal brain areas. Also, bad sleepers showed an anxious/depressive behavioural phenotype and performed worse than good sleepers at visuospatial working-memory tasks. These findings may help to reveal the effects of sleep quality on daily-life cognitive functioning and further elucidate pathophysiological mechanisms of sleep disorders.

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Effects of sleep duration on neurocognitive development in early adolescents in the USA: a propensity score matched, longitudinal, observational study

Yang¹,

Wang²

2022

The Lancet Child & Adolescent Health

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Possible Mechanisms for Impairments to Learning, Memory, and Attention due to Sleep Deprivation

Cited by 4 publications

References 50 publications

Long-lasting effects of insufficient sleep on neurocognitive development in early adolescence

Long-lasting effects of insufficient sleep on neurocognitive development in early adolescence

Self-Reported Sleep Quality Across Age Modulates Resting-State Functional Connectivity in Limbic and Fronto-Temporo-Parietal Networks: An Exploratory Cross-Sectional fMRI Study

Effects of sleep duration on neurocognitive development in early adolescents in the USA: a propensity score matched, longitudinal, observational study

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