Abstract:The article reports the discovery of a novel signaling cascade opioid-like receptor → Na,K-ATPase/Src → Na V 1.8 channel in the nociceptive neuron membrane. Triggering this cascade results in the modulation of its effector unit-the Na V 1.8 channel activation gating device, whereas the Na,K-ATPase/Src complex performs the signal transducer function. The cascade has three targets. Their modulation by the attacking molecules may evoke an antinociceptive response at the peripheral level. The first target is the o… Show more
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