Possible link between the cognitive dysfunction associated with diabetes mellitus and the neurotoxicity of methylglyoxal

Huang, Xiaobo; Wang, Fen; Chen, Wenqiang; Chen, Yujing; Wang, Ningqun; Maltzan, Kristine von

doi:10.1016/j.brainres.2012.06.011

Cited by 44 publications

(32 citation statements)

References 43 publications

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“…We found in this study that hippocampal Bcl-2 and Bcl-XL expressions decreased more and Bax expressions were increasedmore in the hippocampus of diabetic rats than those of the controls. These results are in line with those of many similar studies, most of which were done in vitro Fu et al, 2012;Bournival et al, 2012;Huang et al, 2012). In one of these in vitro studies, Fu et al (2012) reported increased Bax expressions and decreased Bcl-2 expressions in different glucose…”

Section: Accepted Manuscriptsupporting

confidence: 95%

“…In recent studies, the number of TUNEL positive cells have been observed to increase more in the brains of diabetic animals than in those of the controls (Huang et al, 2012;Liu et al, 2013); but this increase failed to reach statistical significance in the study by Hernández-Fonseca et al (2009). We found in our study that there was significantly more neuronal apoptosis in the hippocampus of diabetic rats than in those of the controls.…”

Section: Accepted Manuscriptcontrasting

confidence: 78%

“…Additionally, induction of the apoptosis by increased activation of pro-inflammatory cytokines such as Nuclear Factor KappaB (NF-kB) (Alvarez-Nölting et al, 2012;Muriach et al, 2006;Jing et al, 2013) and Tumor Necrosis Factor-α (TNF-α) (Marfella et al, 2006;Jing et al, 2013) in streptozotocin (STZ) diabetic rats have been previously reported. Consistent to the above mentioned mechanisms, increased numbers of TUNEL positive cells have been observed in various brain regions of diabetic animals (Li et al, 2002;Hernández-Fonseca et al 2009;Huang et al 2012;Liu et al, 2013).…”

Section: Introductionsupporting

confidence: 65%

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Grape seed extract has superior beneficial effects than vitamin E on oxidative stress and apoptosis in the hippocampus of streptozotocin induced diabetic rats

Yonguc

Dodurga

Adıgüzel

et al. 2015

Gene

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Section: Accepted Manuscriptsupporting

confidence: 95%

Section: Accepted Manuscriptcontrasting

confidence: 78%

Section: Introductionsupporting

confidence: 65%

See 1 more Smart Citation

Grape seed extract has superior beneficial effects than vitamin E on oxidative stress and apoptosis in the hippocampus of streptozotocin induced diabetic rats

Yonguc

Dodurga

Adıgüzel

et al. 2015

Gene

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“…Also, a number of cellular metabolic pathways about AG neuroprotective functions relate to methylglyoxal (MG) inhibition (40). MG acts as either an endogenous fatal substance (41) or an effective source of ROS (42), which frequently build up in the hippocampal neurons in hyperglycemia (43,44,45). However, the lack of MG, AGEs, ROS and iNOS measurement is a limitation in our study.…”

Section: Discussionmentioning

confidence: 96%

“…In the memory defect due to diabetes, apoptosis in hippocampal neurons plays a primary role (47,48). On the other hand, it has been indicated that apoptosis in the hippocampus due to altering expression of Bcl-2 family proteins in the neurons could relate to reactive MG, ROS and RNS (44,47,49,50). The imbalance of pro/anti-apoptotic signals of Bcl-2 family plays a crucial role in the release of apoptogenic mitochondrial mediators (51,52).…”

Section: Discussionmentioning

confidence: 99%

Effect of sub-chronic intraperitoneal administration of aminoguanidine on the memory and hippocampal apoptosis-related genes in diabetic rats

Alipour¹,

Amini²,

Adineh³

et al. 2016

BLL

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Memory impairment is a common disorder in diabetes mellitus which is associated with hippocampal neuronal apoptosis. The present study was conducted to examine the effect of one-week intraperitoneal (ip), administration of aminoguanidine (AG) on passive avoidance learning (PAL) and Bcl-2 family gene expression in the hippocampus of rats. Sixty male rats were divided into ten groups: non-diabetic/diabetic animals with/without AG (50, 100, 200 and 400 mg/kg, ip) treatment for one week. PAL and Bcl-2 family genes were examined. AG (100 and 200 mg/kg) improved both memory and Bax, Bak, Bcl-2 and Bcl-xl defi ciency signifi cantly in diabetic rats. AG treatment also ameliorated the diabetes-induced changes in (Bcl-2+Bcl-xl)/(Bak+Bax) ratios considerably. These results propose that one-week ip administration of AG may recover the defi cit cognition in diabetic rats via enhancing (Bcl-2+Bcl-xl)/(Bak+Bax) proportions (Tab. 2, Fig. 4, Ref. 55). Text in PDF www.elis.sk.

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Potential Mechanisms of Methylglyoxal‐Induced Human Embryonic Kidney Cells Damage: Regulation of Oxidative Stress, DNA Damage, and Apoptosis

Liú

Cheng

Tang

et al. 2022

Chemistry & Biodiversity

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Methylglyoxal (MGO) is a reactive carbonyl species that can cause cellular damage and is closely related to kidney disease, especially diabetic nephropathy. The toxic effect of MGO (0.5, 1, and 2 mM) on human embryonic kidney (HEK293) cells and its underlying mechanisms were explored in this study. Cell viability, apoptosis and the signaling pathways were measured with MTT, fluorescent staining and western blot experiments, the results showed that MGO could induce oxidative stress and cell inflammation, the level of reactive oxygen species (ROS) increased, and p38MAPK, JNK and NF‐κB signaling pathways were activated. Meanwhile, MGO also induced DNA damage. The expression of DNA oxidative damage marker 8‐hydroxy‐2’‐deoxyguanosine (8‐OHdG) increased, the expression of double‐strand break marker γH2AX increased significantly, and ATM/Chk2/p53 DNA damage response signaling pathway was activated. Furthermore, the expression of the receptor for advanced glycation end products (RAGE) also increased. Finally, mitochondrial membrane potential (MMP) decreased, fluorescence intensity of Hoechst33258 increased, and the protein expression ratio of Bax/Bcl‐2 increased significantly after the treatment of MGO. These results demonstrated that MGO might induce HEK293 cells damage by regulating oxidative stress, inflammation, DNA damage, and cell apoptosis, which revealed the specific mechanisms of MGO‐induced damage to HEK293 cells.

show abstract

Possible link between the cognitive dysfunction associated with diabetes mellitus and the neurotoxicity of methylglyoxal

Cited by 44 publications

References 43 publications

Grape seed extract has superior beneficial effects than vitamin E on oxidative stress and apoptosis in the hippocampus of streptozotocin induced diabetic rats

Grape seed extract has superior beneficial effects than vitamin E on oxidative stress and apoptosis in the hippocampus of streptozotocin induced diabetic rats

Effect of sub-chronic intraperitoneal administration of aminoguanidine on the memory and hippocampal apoptosis-related genes in diabetic rats

Potential Mechanisms of Methylglyoxal‐Induced Human Embryonic Kidney Cells Damage: Regulation of Oxidative Stress, DNA Damage, and Apoptosis

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