Possible Kawasaki disease in a 20-year-old woman

Schlossberg, D.

doi:10.1001/archderm.115.12.1435

Cited by 7 publications

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“…Many attempts have been made to find the causative microorganism among viruses, bacteria, spirochetes, and fungi, but no definite evidence has been obtained (14). Suspicion that KD may be a toxin-related disease comes from several reports indicating similarities in symptoms between toxic shock syndrome and KD (15)(16)(17)(18). Similarities to scarlet fever have been noted in skin and oral eruptions of KD, but KD affects much younger children than scarlet fever, and isolation of P-hemolytic streptococci is infrequent in patients with KD (2).…”

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confidence: 99%

Detection of Serum Antibody by the Antimitogen Assay against Streptococcal Erythrogenic Toxins. Age Distribution in Children and the Relation to Kawasaki Disease

et al. 1990

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ABSTRACT. W e describe a new method to measure human serum antibody against streptococcal erythrogenic toxins that uses inhibition of lymphocyte mitogenicity of the toxins a s the indicator. Sera from 53% of 53 Kawasaki disease patients contained specific inhibitory activity against A toxin, whereas only 15% had serum inhibitory activity against B toxin. The specific anti-A toxin serum inhibitor was found in 10% of 118 age-matched control patients suffering from various infections and allergic diseases (p = 0.001, compared to Kawasaki disease patients).

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confidence: 99%

Detection of Serum Antibody by the Antimitogen Assay against Streptococcal Erythrogenic Toxins. Age Distribution in Children and the Relation to Kawasaki Disease

et al. 1990

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“…As discussed above, acute KS and TSS overlap in many features, including fever, erythematous rash, and peripheral edema. Indeed, TSS was originally called adult KS [52,53]. However, most investigators suggest there are two major criteria that distinguish KS from TSS: (a) KS has associated aneurysm development but not TSS, and (b) conversely, KS lacks hypotension which typifies TSS.…”

Section: Laboratory Findings In Ksmentioning

confidence: 99%

Kawasaki syndrome: role of superantigens revisited

Leung

Schlievert

2020

The FEBS Journal

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Kawasaki Syndrome (KS) is an acute vasculitis in children complicated by the development of heart disease. Despite its description over 50 years ago, the etiology of coronary artery disease in KS is unknown. High dose intravenous immunoglobulin is the most effective approach to reduce cardiovascular complications. It remains unclear why patients with KS develop coronary artery aneurysms. A subset of patients are resistant to immunoglobulin therapy. Given the heterogeneity of clinical features, variability of history, and therapeutic response, KS may be a cluster of phenotypes triggered by multiple infectious agents and influenced by various environmental, genetic, and immunologic responses. The cause of KS is unknown, and a diagnostic test remains lacking. A better understanding of mechanisms leading to acute KS would contribute to a more precision medicine approach for this complex disease. In the current viewpoint, we make the case for microbial superantigens as important causes of KS.

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The staphylococcus—New features 100 years after its discovery

Gemmell

1982

Journal of Infection

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Possible Kawasaki disease in a 20-year-old woman

Abstract: We describe a 20-year-old woman in whom an illness developed that was consistent with Kawasaki disease. Kawasaki disease may not be confined exclusively to the pediatric age group.

Cited by 7 publications

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Detection of Serum Antibody by the Antimitogen Assay against Streptococcal Erythrogenic Toxins. Age Distribution in Children and the Relation to Kawasaki Disease

Detection of Serum Antibody by the Antimitogen Assay against Streptococcal Erythrogenic Toxins. Age Distribution in Children and the Relation to Kawasaki Disease

Kawasaki syndrome: role of superantigens revisited

The staphylococcus—New features 100 years after its discovery

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