Possible involvement of TWIST in enhanced peritoneal metastasis of epithelial ovarian carcinoma

Terauchi, Mikio; Kajiyama, Hiroaki; Yamashita, Mamoru; Kato, Mikihiko; Tsukamoto, Hirohisa; Umezu, Tomokazu; Hosono, Satoyo; Yamamoto, Eiko; Shibata, Kiyosumi; Ino, Kazuhiko; Nawa, Akihiro; Nagasaka, Tetsuro; Kikkawa, Fumitaka

doi:10.1007/s10585-007-9070-1

Cited by 60 publications

(48 citation statements)

References 47 publications

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“…Especially, peritoneal dissemination is the most common presentation, consisting of multi steps: First, tumor cells are released from the original tumor, and then they migrate in the abdominal cavity. When the tumor cells attach to the peritoneum, they start to invade tissues through the mesothelium (20,21). In the current investigation of 40 EOC patients, various levels of ZEB1 expression were identified in 82.5% (33 of 40), and patients with higher ZEB1 expressions showed a significantly poorer prognosis.…”

Section: Discussionmentioning

confidence: 69%

Impact of positive ZEB1 expression in patients with epithelial ovarian carcinoma as an oncologic outcome-predicting indicator

et al. 2017

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Abstract. Several previous studies have revealed that the expression of zinc finger E-box binding homeobox 1 (ZEB1) in solid malignancies has an important significance on the clinical outcome of patients. However, the association between ZEB1 expression and survival in patients with epithelial ovarian carcinoma (EOC) remains unclear. The objective of the present study was to examine the extent of ZEB1 expression in EOC using immunohistochemical staining and investigate its association with patient outcome. A total of 40 patients with EOC initially treated with cytoreductive surgery and systematic chemotherapy were enrolled. ZEB1 expression was immunohistochemically categorized as negative, weak, moderate and strong according to the size of the staining area, and intensity. Subsequently, the associations between ZEB1 expression and recurrence/progression-free survival (RFS) rate were examined. The median age of patients in the current study was 54 years old (range, 22-72 years old). Among these patients, 15 (37.5%) exhibited International Federation of Gynecology and Obstetrics stage I disease, and 10 (25.0%), 13 (32.5%), and 2 (5%) had stage II, III, and IV disease, respectively. No patients with negative expression of ZEB1 experienced recurrence. In addition, ZEB1 expression was identified to be a significant predictor of a poorer RFS rate compared with negative expression (negative vs. weak, moderate and strong, P= 0.0126). Furthermore, multivariate analyses revealed that moderate and strong ZEB1 expression levels were significant prognostic indicators of a poorer RFS rate in patients with EOC (hazard ratio, 2.265; 95% confidence interval, 1.072-8.021; P=0.0349). Confining analysis to patients with the clear-cell/mucinous histological type, those with moderate/strong ZEB1 expression demonstrated a significantly poorer RFS rate (P=0.0025). Positive ZEB1 expression may be an indicator to predict unfavorable RFS in patients with EOC.

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Section: Discussionmentioning

confidence: 69%

Impact of positive ZEB1 expression in patients with epithelial ovarian carcinoma as an oncologic outcome-predicting indicator

et al. 2017

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“…SNAIL represses the cell cycle and enhances resistance to cell death (Vega et al, 2004). TWIST1 promotes intracavitary dissemination of ovarian cancers, which require resistance to anoikis (Terauchi et al, 2007). Taken together, EMT may be a crucial process in the metastasis of HMM cells via intracavitary dissemination.…”

Section: Discussionmentioning

confidence: 99%

Hydrogen Peroxide Promotes Epithelial to Mesenchymal Transition and Stemness in Human Malignant Mesothelioma Cells

Kim¹,

Cui²,

Kim³

2013

Asian Pacific Journal of Cancer Prevention

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Reactive oxygen species (ROS) are known to promote mesothelial carcinogenesis that is closely associated with asbestos fibers and inflammation. Epithelial to mesenchymal cell transition (EMT) is an important process involved in the progression of tumors, providing cancer cells with aggressiveness. The present study was performed to determine if EMT is induced by H 2 O 2 in human malignant mesothelioma (HMM) cells. Cultured HMM cells were treated with H 2 O 2 , followed by measuring expression levels of EMT-related genes and proteins. Immunohistochemically, TWIST1 expression was confined to sarcomatous cells in HMM tissues, but not in epithelioid cells. Treatment of HMM cells with H 2 O 2 promoted EMT, as indicated by increased expression levels of vimentin, SLUG and TWIST1, and decreased E-cadherin expression. Expression of stemness genes such as OCT4, SOX2 and NANOG was also significantly increased by treatment of HMM cells with H 2 O 2 . Alteration of these genes was mediated via activation of hypoxia inducible factor 1 alpha (HIF-1α) and transforming growth factor beta 1 (TGF-β1). Considering that treatment with H 2 O 2 results in excess ROS, the present study suggests that oxidative stress may play a critical role in HMM carcinogenesis by promoting EMT processes and enhancing the expression of stemness genes.

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“…Each of both proteins, α v β 3 -integrin as well as MT1-MMP, have been shown to be important for EMT [122,212]. The co-expression and most likely co-operation of MT1-MMP and β 1 -integrin in EMTdriven invasiveness, under the control of the transcription factor Twist, suggests that proteins relevant for invadopodia formation are important for EMT as well [213].…”

Section: Podosomes and Invadopodiamentioning

confidence: 99%

EMT, the cytoskeleton, and cancer cell invasion

Yilmaz

Christofori

2009

Cancer Metastasis Rev

1,502

1,314

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The metastatic process, i.e. the dissemination of cancer cells throughout the body to seed secondary tumors at distant sites, requires cancer cells to leave the primary tumor and to acquire migratory and invasive capabilities. In a process of epithelial-mesenchymal transition (EMT), besides changing their adhesive repertoire, cancer cells employ developmental processes to gain migratory and invasive properties that involve a dramatic reorganization of the actin cytoskeleton and the concomitant formation of membrane protrusions required for invasive growth. The molecular processes underlying such cellular changes are still only poorly understood, and the various migratory organelles, including lamellipodia, filopodia, invadopodia and podosomes, still require a better functional and molecular characterization. Notably, direct experimental evidence linking the formation of migratory membrane protrusions and the process of EMT and tumor metastasis is still lacking. In this review, we have summarized recent novel insights into the molecular processes and players underlying EMT on one side and the formation of invasive membrane protrusions on the other side.

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Possible involvement of TWIST in enhanced peritoneal metastasis of epithelial ovarian carcinoma

Cited by 60 publications

References 47 publications

Impact of positive ZEB1 expression in patients with epithelial ovarian carcinoma as an oncologic outcome-predicting indicator

Impact of positive ZEB1 expression in patients with epithelial ovarian carcinoma as an oncologic outcome-predicting indicator

Hydrogen Peroxide Promotes Epithelial to Mesenchymal Transition and Stemness in Human Malignant Mesothelioma Cells

EMT, the cytoskeleton, and cancer cell invasion

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