Possible involvement of transcriptional activation of nuclear factor erythroid 2-related factor 2 (Nrf2) in the protective effect of caffeic acid on paraquat-induced oxidative damage in Drosophila melanogaster

Nunes, Ricardo Gomes dos Santos; Pereira, Pedro Silvino; Elekofehinti, Olusola Olalekan; Fidelis, Kleber Ribeiro; Silva, Cícera Simoni da; Ibrahim, Mohammad; Barros, Luiz Marivando; Cunha, Francisco Assis Bezerra da; Lukong, Kiven Erique; Menezes, Irwin Rose Alencar de; Tsopmo, Apollinaire; Duarte, Antônia Eliene; Kamdem, Jean Paul

doi:10.1016/j.pestbp.2019.03.017

Cited by 27 publications

(2 citation statements)

References 70 publications

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“…Regarding oxidation, 50 µg mL −1 of CAO and NCAO did not significantly affect Nrf2 nuclear translocation compared to CA and NCA, respectively. Their oxidation products, including caffeic acid, coumaric acid and vanillic acid, also possessed significant capacity for transcriptional activation of nuclear factor Nrf2 (Dos Santos Nunes et al ., 2019; Shen et al ., 2019), which could protect cells from oxidative damage. For NF‐ κ B nuclear translocation, CA oxidation had no remarkable effects on NF‐ κ B nuclear translocation, and oxidation of NCA reduced its NF‐ κ B nucleic level.…”

Section: Discussionmentioning

confidence: 99%

Effects of isomerisation and oxidation on the immunomodulatory activity of chlorogenic acid in RAW264.7 macrophages

Guo

Lyu

et al. 2021

Int J of Food Sci Tech

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Summary Chlorogenic acid (CA) is one of the major polyphenols in fruit that contributes to most bioactivities. However, it is susceptible to isomerisation and oxidation in processing and thus displays varied bioactivity. This study aimed to evaluate the isomerisation and oxidation effects of CA on the potential immunomodulatory activity in RAW264.7 macrophages through the NF‐E2‐related factor‐2 (Nrf2) and nuclear factor‐kappa B (NF‐κB) signalling pathways. The results showed that isomerisation significantly affected the immunomodulation of CA by reducing Nrf2 and increasing NF‐κB nuclear translocation. The oxidation of CA weakened the effect of immune regulation in macrophages through impacts on the nucleic translocation of Nrf2 and NF‐κB, cellular reactive oxygen species (ROS) accumulation, antioxidant enzyme (superoxide dismutase, SOD) activity and cytokine expression. Consequently, isomerisation and oxidation remarkably affect the immunomodulation of CA via the Nrf2 and NF‐κB pathways.

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Section: Discussionmentioning

confidence: 99%

Effects of isomerisation and oxidation on the immunomodulatory activity of chlorogenic acid in RAW264.7 macrophages

Guo

Lyu

et al. 2021

Int J of Food Sci Tech

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“…O NPSH é um tripéptideo, comprometido em várias ações biológicas, incluindo reações enzimáticas, transporte molecular, biossíntese de proteínas, genes expressão e proteção das células contra prejuízos oxidativos (MULIER, 1998;TABREZ et al, 2012). A glutationa (GSH), é um relevante antioxidante intracelular em células e tecidos que protegem em relação aos processos de estresse oxidativo (dos Santos Nunes et al, 2019). Ambos com a presença de substâncias tóxicas, ocasionam a diminuição dos mesmos e consequentemente diminui a proteção contra danos oxidativos nas células (ZHAO et al, 2017;SHIVANANDAPPA, 2018).…”

Section: Análise Estatísticaunclassified

Anais Do I Congresso Luso-Brasileiro De Saúde Coletiva (On-Line) – Resumos Expandidos

2023

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Caro leitor,A discussão sobre saúde coletiva no Brasil e em Portugal é fundamental para melhorar a qualidade de vida da população, promover a equidade no acesso à saúde, garantir sistemas de saúde eficientes e eficazes, prevenir doenças e responder a crises de saúde.Essa discussão tem impacto direto na vida de todas as pessoas e na construção de sociedades mais saudáveis e justas.Desta forma, o I Congresso Luso-Brasileiro de Saúde Coletiva (On-line) -I CO-LUBRASC é um evento internacional voltado para a atualização e difusão das ações e saberes direcionados a promoção, proteção e recuperação da saúde das populações do Brasil e de Portugal, assim como a troca de informações entre os profissionais desses países. Esse evento é indicado para estudantes, profissionais e pesquisadores de Portugal e do Brasil.Dentre os excelentes resumos publicados nos anais deste evento, abaixo estão os títulos dos que receberam certificados de menção honrosa:

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Links Between Paraquat and Parkinson’s Disease

Martínez-Chacón

Yakhine-Diop

González‐Polo

et al. 2021

Handbook of Neurotoxicity

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Possible involvement of transcriptional activation of nuclear factor erythroid 2-related factor 2 (Nrf2) in the protective effect of caffeic acid on paraquat-induced oxidative damage in Drosophila melanogaster

Cited by 27 publications

References 70 publications

Effects of isomerisation and oxidation on the immunomodulatory activity of chlorogenic acid in RAW264.7 macrophages

Effects of isomerisation and oxidation on the immunomodulatory activity of chlorogenic acid in RAW264.7 macrophages

Anais Do I Congresso Luso-Brasileiro De Saúde Coletiva (On-Line) – Resumos Expandidos

Links Between Paraquat and Parkinson’s Disease

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