Possible involvement of the dopamine D3 receptor locus in subtypes of bipolar affective disorder

The DRD3 Ser9Gly Polymorphism Predicted Metabolic Change in Drug-Naive Patients With Bipolar II Disorder

“…20 The DRD3 gene, on chromosome 3q13.3, is expressed at a relatively high level in the mesolimbic brain regions associated with emotions and behavior, novelty seeking, the reward system, and cognition. 21–24 Therefore, the DRD3 gene might be important for susceptibility to BD and metabolic change, because mood swings, neurocognitive impairments, and the reward system are all important aspects of BD 25 and are related to appetite change, which affects metabolic parameters. Chiaroni et al 25 suggested that the DRD3 locus might be involved in a specific endophenotype of BD that consists of clinical characteristics of mania, a low age at onset, and initiation by an acute delusional episode.…”

“…21–24 Therefore, the DRD3 gene might be important for susceptibility to BD and metabolic change, because mood swings, neurocognitive impairments, and the reward system are all important aspects of BD 25 and are related to appetite change, which affects metabolic parameters. Chiaroni et al 25 suggested that the DRD3 locus might be involved in a specific endophenotype of BD that consists of clinical characteristics of mania, a low age at onset, and initiation by an acute delusional episode. Our research 26 also suggests an association between the DRD3 Serine-9-Glycine (Ser9Gly) polymorphism and BDII comorbid with anxiety disorder.…”

Genome-wide scan for genes involved in bipolar affective disorder in 70 European families ascertained through a bipolar type I early-onset proband: supportive evidence for linkage at 3p14

“…These genes might have only a weak effect on BPAD or this result may be due to the peculiarities of our sample, such as mode of ascertainment or false-positive results. 13,14,16 As there is large confidence interval for linkage in these regions (i.e. 38 cM for 2p21, 25 cM for 2q14.3, 18 cM for 3p14, 33 cM for 5q33, 18 cM for 7q36, 17 cM for 10q23 and 12 cM for the 20p12 regions), we are currently undergoing the fine mapping of the regions of interest.…”

“…10 Several association studies investigating early-onset BPAD subgroups suggested the implication of candidate genes such as those encoding glycogen synthase kinase 3-beta (OMIM number 605004) 13 and the dopamine receptor D3 (OMIM number 126451). 14 Finally, polymorphisms in the serotonin transporter (SLC6A4 -OMIM number 182138) and apolipoprotein E (OMIM number 107741) genes seem to influence BPAD AAO. [15][16][17] Thus, we hypothesized that focusing on families ascertained through an early-onset type I BPAD proband might reduce the heterogeneity of the BPAD phenotype, thus increasing the probability of detecting risk loci by linkage analysis.…”

Investigação de genes candidatos para psicoses funcionais: estudo caso-controle com mães e crianças (população de alto risco)

“…Apenas um estudo encontrou associação do alelo DRD3 Ser e a suscetibilidade de transtorno bipolar (Parsian A. et al, 1995), outros estudos não confirmaram esta associação (Heiden et al 2000, Chiaroni P. et al, 2000.…”