Possible Involvement of Signal Transducer and Activator of Transcription-3 (STAT3) Signaling Pathway in the Initiation and Progression of Hepatocellular Carcinoma

Subramaniam, Aruljothi; Shanmugam, Muthu K.; Perumal, Ekambaram; Li, Feng; Nachiyappan, Alamelu; Kumar, Alan Prem; Tan, Benny K.H.; Sethi, Gautam

doi:10.1007/978-81-322-1533-2_6

Cited by 2 publications

(1 citation statement)

References 89 publications

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“…Particularly, IL-6 is important for the production of HCC (41, 42) and is able to activate STAT3 via IL-6 receptor, gp130 and JAKs (43, 44). Upon attaching of IL-6 to its receptor, dimerization of the gp130 receptor occurs and causes subsequent activation of JAK due to its association with gp130 (25, 45, 46). Three members of the JAK family of proteins, JAK1, JAK2, and TYK2 can be activated by this manner (47, 48).…”

Section: Molecular Regulation Of Stat 3/5 Protein Activationmentioning

confidence: 99%

Signal Transducer and Activator of Transcription (STATs) Proteins in Cancer and Inflammation: Functions and Therapeutic Implication

et al. 2019

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Signal Transducer and Activator of Transcription (STAT) pathway is connected upstream with Janus kinases (JAK) family protein and capable of integrating inputs from different signaling pathways. Each family member plays unique functions in signal transduction and crucial in mediating cellular responses to different kind of cytokines. STAT family members notably STAT3 and STAT5 have been involved in cancer progression whereas STAT1 plays opposite role by suppressing tumor growth. Persistent STAT3/5 activation is known to promote chronic inflammation, which increases susceptibility of healthy cells to carcinogenesis. Here, we review the role of STATs in cancers and inflammation while discussing current therapeutic implications in different cancers and test models, especially the delivery of STAT3/5 targeting siRNA using nanoparticulate delivery system.

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Section: Molecular Regulation Of Stat 3/5 Protein Activationmentioning

confidence: 99%

Signal Transducer and Activator of Transcription (STATs) Proteins in Cancer and Inflammation: Functions and Therapeutic Implication

et al. 2019

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Targeting multiple oncogenic pathways for the treatment of hepatocellular carcinoma

et al. 2016

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Hepatocellular carcinoma (HCC) is one of the most common forms of liver cancer diagnosed worldwide. HCC occurs due to chronic liver disease and is often diagnosed at advanced stages. Chemotherapeutic agents such as doxorubicin are currently used as first-line agents for HCC therapy, but these are non-selective cytotoxic molecules with significant side effects. Sorafenib, a multi-targeted tyrosine kinase inhibitor, is the only approved targeted drug for HCC patients. However, due to adverse side effects and limited efficacy, there is a need for the identification of novel pharmacological drugs beyond sorafenib. Several agents that target and inhibit various signaling pathways involved in HCC are currently being assessed for HCC treatment. In the present review article, we summarize the diverse signal transduction pathways responsible for initiation as well as progression of HCC and also the potential anticancer effects of selected targeted therapies that can be employed for HCC therapy.

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Possible Involvement of Signal Transducer and Activator of Transcription-3 (STAT3) Signaling Pathway in the Initiation and Progression of Hepatocellular Carcinoma

Cited by 2 publications

References 89 publications

Signal Transducer and Activator of Transcription (STATs) Proteins in Cancer and Inflammation: Functions and Therapeutic Implication

Signal Transducer and Activator of Transcription (STATs) Proteins in Cancer and Inflammation: Functions and Therapeutic Implication

Targeting multiple oncogenic pathways for the treatment of hepatocellular carcinoma

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