Possible Involvement of Serum and Synovial Fluid Resistin in Knee Osteoarthritis: Cartilage Damage, Clinical, and Radiological Links

Song, Yong-Zhou; Guan, Jian; Wang, Huajun; Ma, Wei; Li, Feng; Xu, Fang; Ding, Luo-Bin; Xie, Lei; Liu, Bo; Li, Kai; Lv, Zhe

doi:10.1002/jcla.21876

Cited by 34 publications

(21 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This association could explain the effect of visfatin in pain, but to our knowledge its association with KOA pain has not been clinically evaluated, and it is possible that under the stimuli of different inflammatory factors visfatin may exert different local actions in KOA. A prior study showed an association between the WOMAC-total score and the WOMAC subscales with synovial fluid resistin but not with plasma resistin levels, suggesting that the local effects of resistin might be more important than the systemic ones but, in contrast to our study, patients had advanced disease and it was not focused on people with joint effusion 18 . In this regard, our group may have a greater inflammatory local effect of resistin.…”

Section: Discussioncontrasting

confidence: 92%

Differential involvement of synovial adipokines in pain and physical function in female patients with knee osteoarthritis. A cross-sectional study

Calvet

Orellana

Giménez³

et al. 2018

Osteoarthritis and Cartilage

View full text Add to dashboard Cite

show abstract

Section: Discussioncontrasting

confidence: 92%

Differential involvement of synovial adipokines in pain and physical function in female patients with knee osteoarthritis. A cross-sectional study

Calvet

Orellana

Giménez³

et al. 2018

Osteoarthritis and Cartilage

View full text Add to dashboard Cite

show abstract

“…Resistin may act in a proinflammatory manner, and has been linked to the development of OA [16,17,19,23]. Resistin levels are associated with the severity of symptoms and radiological cartilage degeneration in KOA patients [33][34][35]. Consistent with previous studies, serum levels of resistin were higher in KOA patients than in healthy controls, although no significant difference between the two was found after adjustment.…”

Section: Discussionsupporting

confidence: 73%

Resistin Induces Chemokine and Matrix Metalloproteinase Production via CAP1 Receptor and Activation of P38-MAPK and NF-κB Signalling Pathways in Human Chondrocytes

Zhao

Song

Liu

et al. 2020

Preprint

Self Cite

View full text Add to dashboard Cite

BackgroundResistin is an adipokine also detected higher expression in serum and synovial fluid of patients with knee osteoarthritis (KOA). Resistin is known to be related closely to insulin resistance and inflammation. However, the pathogenic role of resistin in KOA remain unclear. Purpose of the study is to investigate whether resistin induces KOA by binding to functional receptor adenylyl cyclase-associated protein 1 (CAP1) and activating the p38 mitogen-activated protein kinase (p38-MAPK) and nuclear factor-κB (NF-κB) signalling pathways in human chondrocytes. MethodsWe enrolled 103 patients with radiographic KOA and 86 healthy participants as controls. The levels of resistin in serum and synovial fluid (SF) were determined via enzyme-linked immunosorbent assay (ELISA). CAP1 expression in cartilage tissues (21 samples of KOA cartilage and 10 samples of healthy hip cartilage) was measured using immunohistochemistry (IHC), quantitative real-time polymerase chain reaction ( qRT-PCR ), and western blotting assays. Effects of resistin on chondrocytes and CAP1 were evaluated via qRT-PCR and co-immunoprecipitation . The roles of CAP1, p38-MAPK, and NF-κB signalling pathways in the development of KOA were evaluated via adenovirus-mediated CAP1 short hairpin RNA, qRT-PCR, western blotting, and ELISA. ResultsExpression of resistin in serum and SF was elevated in severe radiographic KOA. CAP1 levels were higher in KOA cartilage and were positively correlated with resistin expression. Resistin promoted increased expression of CCL3, CCL4, MMP13, and ADAMTS-4 through CAP1 receptor. Resistin also directly bound to CAP1 as confirmed by co-immunoprecipitation. CAP1 knockdown in chondrocytes attenuated resistin-induced expression of CCL3, CCL4, MMP13, and ADAMTS-4 and activation of the p38-MAPK and NF-κB signalling pathways . ConclusionsOur study shows that resistin bound to CAP1 and upregulated the expression of proinflammatory cytokines and matrix-degrading enzymes via p38-MAPK and NF-κB signalling pathways in human chondrocytes.

show abstract

“…Similarly, another study also found an association with the WOMAC score and CTX-II and resistin level in synovial fluid of patients undergoing arthroscopic lavage [175]. Recently, among knee OA patients, serum level of resistin was significantly associated with Kellgren-Lawrence grading scores, WOMAC pain scores, physical functional scores, WOMAC total scores, and CTX-II [175]. …”

Section: Adipokines In the Pathobiology Of Osteoarthritic Cartilagementioning

confidence: 94%

Adipokine Contribution to the Pathogenesis of Osteoarthritis

Azamar-Llamas

Hernández-Molina

Ramos-Ávalos

et al. 2017

Mediators of Inflammation

132

106

View full text Add to dashboard Cite

Recent studies have shown that overweight and obesity play an important role in the development of osteoarthritis (OA). However, joint overload is not the only risk factor in this disease. For instance, the presence of OA in non-weight-bearing joints such as the hand suggests that metabolic factors may also contribute to its pathogenesis. Recently, white adipose tissue (WAT) has been recognized not only as an energy reservoir but also as an important secretory organ of adipokines. In this regard, adipokines have been closely associated with obesity and also play an important role in bone and cartilage homeostasis. Furthermore, drugs such as rosuvastatin or rosiglitazone have demonstrated chondroprotective and anti-inflammatory effects in cartilage explants from patients with OA. Thus, it seems that adipokines are important factors linking obesity, adiposity, and inflammation in OA. In this review, we are focused on establishing the physiological mechanisms of adipokines on cartilage homeostasis and evaluating their role in the pathophysiology of OA based on evidence derived from experimental research as well as from clinical-epidemiological studies.

show abstract

Possible Involvement of Serum and Synovial Fluid Resistin in Knee Osteoarthritis: Cartilage Damage, Clinical, and Radiological Links

Abstract: Resistin in SF might serve as a potential biomarker for reflecting the disease severity and cartilage degenerative extent of knee OA.

Cited by 34 publications

References 31 publications

Differential involvement of synovial adipokines in pain and physical function in female patients with knee osteoarthritis. A cross-sectional study

Differential involvement of synovial adipokines in pain and physical function in female patients with knee osteoarthritis. A cross-sectional study

Resistin Induces Chemokine and Matrix Metalloproteinase Production via CAP1 Receptor and Activation of P38-MAPK and NF-κB Signalling Pathways in Human Chondrocytes

Adipokine Contribution to the Pathogenesis of Osteoarthritis

Contact Info

Product

Resources

About