Possible Involvement of Myofibroblasts in Cellular Recovery of Uranyl Acetate-Induced Acute Renal Failure in Rats

Sun, Dezheng; Fujigaki, Yoshihide; Fujimoto, Takao; Yonemura, Katsuhiko; Hishida, Akira

doi:10.1016/s0002-9440(10)64647-0

Cited by 50 publications

(52 citation statements)

References 30 publications

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“…Leukocytes, measured by either esterase staining or MPO assay, are only transiently found in the kidney (Fig. 5), which is similar to previous findings in the uranyl acetate model, where ED-1-positive cells transiently emigrate to the region of injury and then gradually disappear after the tubules have regenerated (35). Strategies that inhibit inflammation would not be expected to decrease renal damage, and might even increase tubular damage, in the HgCl 2 model.…”

Section: Lack Of Effect Of ␣-Msh or Il-10supporting

confidence: 87%

α-Melanocyte-simulating hormone and interleukin-10 do not protect the kidney against mercuric chloride-induced injury

Miyaji

Star

2002

American Journal of Physiology-Renal Physiology

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Section: Lack Of Effect Of ␣-Msh or Il-10supporting

confidence: 87%

α-Melanocyte-simulating hormone and interleukin-10 do not protect the kidney against mercuric chloride-induced injury

Miyaji

Star

2002

American Journal of Physiology-Renal Physiology

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“…75,76 Again in this situation, prevention of fibrosis would be counterproductive. Following on from this hypothesis however, the long-term deposition of fibrosis which does not regress might be detrimental to the kidney.…”

Section: Renal Inflammation and Fibrosis: The Kidney's Response To Inmentioning

confidence: 99%

Current Understanding of the Pathogenesis of Progressive Chronic Kidney Disease in Cats

Jepson

2016

Veterinary Clinics of North America: Small Animal Practice

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Abstract:In cats with chronic kidney disease (CKD), the most common histopathological finding is tubulointerstitial inflammation and fibrosis. However, these changes reflect a non-specific response of the kidney to any inciting injury. The risk of development of CKD in a patient is likely to reflect genetic predispositions, ageing, environmental and individual factors that influence decline in renal function over the course of a cat's life. However, there is still relatively little information about exactly which risk factors predispose a cat to develop CKD and these will be explored. Whilst many cats diagnosed with CKD have stable disease for many years, some cats show overtly progressive disease.

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“…In addition to HSCs and mesenchymal stem cells (Kale et al, 2003;Lin et al, 2003;Morigi et al, 2004), differentiated epithelial cells within the kidney have been implicated in renal remodeling. After renal injury, epithelial cells may acquire mesenchymal characteristics before proliferation, thereby contributing to basement membrane repair (Sun et al, 2000;Poulsom et al, 2003). It was suggested that this is the most important mechanism of renal regeneration (Duffield and Bonventre, 2005).…”

Section: Role Of P-gp and Bcrp In Renal Regenerationmentioning

confidence: 99%

The Role of ATP Binding Cassette Transporters in Tissue Defense and Organ Regeneration

Huls

Rüssel²,

Masereeuw³

2008

J Pharmacol Exp Ther

156

109

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ATP binding cassette (ABC) transporters are ATP-dependent membrane proteins predominantly expressed in excretory organs, such as the liver, intestine, blood-brain barrier, blood-testes barrier, placenta, and kidney. Here, they play an important role in the absorption, distribution, and excretion of drugs, xenobiotics, and endogenous compounds. In addition, the ABC transporters, P-glycoprotein (P-gp/ABCB1) and breast cancer resistance protein (BCRP/ABCG2), are highly expressed in a population of primitive stem cells: the side population (SP). SP cells were originally discovered in bone marrow by their capacity to exclude rhodamine 123 and Hoechst dye 33342; however, extensive research also revealed their presence in other nonhematopoietic tissues. The expression levels of BCRP and P-gp are tightly controlled and may determine the differentiation of SP cells toward other more specialized cell types. Although their exact function in these cells is still not clear, they may protect the cells by pumping out toxicants and harmful products of oxidative stress. Transplantation studies in animals revealed that bone marrow-derived SP cells contribute to organ repopulation and tissue repair after damage, e.g., in liver and heart. The role of SP cells in regeneration of damaged kidney segments is not yet clarified. This review focuses on the role of ABC transporters in tissue defense and regeneration, with specific attention to P-gp and BCRP in organ regeneration and repair.

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Possible Involvement of Myofibroblasts in Cellular Recovery of Uranyl Acetate-Induced Acute Renal Failure in Rats

Cited by 50 publications

References 30 publications

α-Melanocyte-simulating hormone and interleukin-10 do not protect the kidney against mercuric chloride-induced injury

α-Melanocyte-simulating hormone and interleukin-10 do not protect the kidney against mercuric chloride-induced injury

Current Understanding of the Pathogenesis of Progressive Chronic Kidney Disease in Cats

The Role of ATP Binding Cassette Transporters in Tissue Defense and Organ Regeneration

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