Possible Involvement of Keratinocyte Growth Factor in the Persistence of Hyperpigmentation in both Human Facial Solar Lentigines and Melasma

Hasegawa, Kiyozo; Fujiwara, Rumiko; Satô, Kiyoshi; Shin, Jaeyoung; Kim, Sang Jin; Kim, Mi-Sun; Kang, Hee Young

doi:10.5021/ad.2015.27.5.626

Cited by 26 publications

(31 citation statements)

References 10 publications

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“…Actinic lentigos Acute and prolonged, unprotected sun exposure may induce benign spotted hyperpigmentation known as actinic lentigines. 5,6 These localized forms of benign, flat, uniform acquired hyperpigmentations are darker than ephelides and do not darken or increase in number on sun exposure. Their size is usually larger (≥1 cm) than simple lentigines (2-5 mm in diameter).…”

Section: Melanin-related Hyperpigmentationmentioning

confidence: 99%

Laser treatment of hyperpigmented lesions: position statement of the European Society of Laser in Dermatology

Passeron

Genedy

Salah

et al. 2019

Acad Dermatol Venereol

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Background Lasers and intense pulsed light sources (IPLS) are proposed for the treatment of many pigmentary disorders. They are sometimes considered as magic tools able to remove any type of lesions. Although being the best option for several hyperpigmented lesions, they can also worsen some conditions and have potential side‐effects. Objective The aim of this review was to give evidence‐based recommendations for the use of lasers and IPLS in the treatment of hyperpigmented lesions. Methods These recommendations were produced for the European Society of Laser Dermatology by a consensus panel made up of experts in the field of pigment laser surgery. Recommendations on the use of lasers and light treatments were made based on the quality of evidence for efficacy, safety, tolerability, cosmetic outcome, patient satisfaction/preference and, where appropriate, on the experts' opinion. Results Lasers and IPLS are very effective for treating many hyperpigmented lesions such as lentigos, dermal hypermelanocytosis or heavy metal depositions. In the other hand, they have to be considered with great caution for other disorders, such as café au lait macules, melasma or postinflammatory hyperpigmentation. After making the correct diagnosis, if lasers or IPLS are indicated, the optimal wavelengths and parameters will be chosen taking into account the skin phototype, origin and depth of the target pigments. Conclusion Although potentially very effective, lasers and IPLS cannot be proposed for all types of hyperpigmented lesions. In all cases, precise recognition of the disorder is mandatory for choosing between these devices and other therapeutic approaches.

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Section: Melanin-related Hyperpigmentationmentioning

confidence: 99%

Laser treatment of hyperpigmented lesions: position statement of the European Society of Laser in Dermatology

Passeron

Genedy

Salah

et al. 2019

Acad Dermatol Venereol

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“…Ultraviolet‐induced skin pigmentation is regulated by interactions between melanocytes and neighboring cells, such as keratinocytes or fibroblasts . Specifically, an important role of photoaged fibroblasts in the development of UV‐associated hyperpigmentary disorders, solar lentigo or melasma has been suggested . In addition to fibroblasts, growing evidence also implicates blood vessels in pigmentation .…”

Section: Introductionmentioning

confidence: 99%

“…1,2 Specifically, an important role of photoaged fibroblasts in the development of UV-associated hyperpigmentary disorders, solar lentigo or melasma has been suggested. [3][4][5] In addition to fibroblasts, growing evidence also implicates blood vessels in pigmentation. [6][7][8][9] UV exposure elicits angiogenesis and hyperpermeability of blood vessels in the dermis.…”

Section: Introductionmentioning

confidence: 99%

Increased blood flow and vasculature in solar lentigo

Hasegawa

Fujiwara

Satô

et al. 2016

The Journal of Dermatology

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Solar lentigo (SL) is a hallmark of ultraviolet (UV)-induced photoaged skin and growing evidence implicates blood vessels in UV-associated pigmentation. In this study, we investigated whether the vasculatures are modified in SL. Twenty-five women with facial SL were enrolled and colorimetric and blood flow studies were performed. There was a significant increase in erythema which was associated with increased blood flow in the lesional skin compared with perilesional normal skin. Immunohistochemical studies with 24 facial SL biopsies consistently revealed a significant increase in vessel density accompanied by increased levels of vascular endothelial growth factor expression. CD68 immunoreactivity was significantly higher in lesional skin suggesting increased macrophage infiltration in SL. In conclusion, SL is characterized by increased blood flow and vasculature. These findings suggest the possible influence of the characteristics of vasculature on development of SL.

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“…Ultraviolet irradiation stimulates KCs and FBs to secrete numerous cytokines that are responsible for the proliferation and activation of MCs. Keratinocytes secrete KIT ligand (KITL, also known as stem cell factor), prostaglandin, endothelin (ET), KC growth factor, and granulocyte–macrophage colony‐stimulating factor (GM‐CSF), whereas FBs secrete KITL, hepatocyte growth factor (HGF), and basic FB growth factor (bFGF) (Hasegawa et al., ; Imokawa, ; Tanaka et al., ). Photodynamic therapy can affect MCs directly and indirectly.…”

Section: Introductionmentioning

confidence: 99%

“…The photoaging response is characterized by a cross talk between cells including keratinocytes (KCs), FBs, and melanocytes (MCs) (Gegotek et al, 2016;Hasegawa et al, 2015). Ultraviolet irradiation stimulates KCs and FBs to secrete numerous cytokines that are responsible for the *These authors contributed equally to this work.…”

Section: Introductionmentioning

confidence: 99%

Photodynamic therapy inhibits melanogenesis through paracrine effects by keratinocytes and fibroblasts

Kim

Park

et al. 2017

Pigment Cell Melanoma Res

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Photodynamic therapy (PDT) is a treatment option for skin cancer and premalignant skin diseases and exhibits rejuvenation effects, including reducing fine wrinkles and whitening, on aged skin. In this study, we investigated the mechanism underlying the whitening effects of PDT on melanocytes (MCs) in vitro and in vivo. Exposure of MCs to PDT in vitro reduced their melanin content and tyrosinase activity without, however, affecting cell survival. Interestingly, melanogenesis was also inhibited by exposing MCs to conditioned media of PDT-treated keratinocytes or dermal fibroblasts. This paracrine effect was likely due to a decreased release of melanocyte-stimulating cytokines such as Kit ligand and hepatocyte growth factor from these cells. Furthermore, we observed that PDT reduced mottled hyperpigmentation of photoaged patient skin in vivo, highlighting the clinical importance of skin whitening by PDT.

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Possible Involvement of Keratinocyte Growth Factor in the Persistence of Hyperpigmentation in both Human Facial Solar Lentigines and Melasma

Cited by 26 publications

References 10 publications

Laser treatment of hyperpigmented lesions: position statement of the European Society of Laser in Dermatology

Laser treatment of hyperpigmented lesions: position statement of the European Society of Laser in Dermatology

Increased blood flow and vasculature in solar lentigo

Photodynamic therapy inhibits melanogenesis through paracrine effects by keratinocytes and fibroblasts

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