Possible Involvement of Endothelin in Posttransplant Acute Tubular Necrosis. I

YAMADA, KENICHI; Gunji, Yoshio; Hishikawa, Etsuo; KASHIWABARA, HIDEHIKO; Sakamoto, Kaoru; ARITA, SEIJI; YOKOYAMA, TAKEO

doi:10.1097/00007890-199404150-00029

Cited by 9 publications

(3 citation statements)

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“…[ 15 16 17 18 ] There are some reports suggesting that ET-1 is involved in the development of postischemic ARF in clinical transplantation. [ 19 20 ]…”

Section: Discussionmentioning

confidence: 99%

Preventive role of endothelin antagonist on kidney ischemia: Reperfusion injury in male and female rats

et al. 2015

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Background:Renal ischemia/reperfusion injury (RIRI) is the most common cause of acute kidney injury. We tested the protective role of endothelin-1 receptor blocker; bosentan (BOS) in animal model of RIRI in two different genders.Methods:Male and female Wistar rats were assigned as sham operated (sham), control group (ischemia), and case group (ischemia + BOS) treated with BOS (50 mg/kg) 2 h before bilateral kidney ischemia induced by clamping renal vessels for 45 min followed by 24 h of renal reperfusion.Results:The RIRI significantly increased the serum levels of blood urea nitrogen and creatinine in both genders (P < 0.05). These values were significantly decreased by BOS in both genders. In male rats, the serum levels of malondialdehyde in the ischemia + BOS group were decreased significantly when compared with ischemia group (P < 0.05).Conclusions:BOS can be used in both genders to attenuate kidney ischemia injury possibly due to its effect in the renal vascular system.

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“…[ 15 16 17 18 ] There are some reports suggesting that ET-1 is involved in the development of postischemic ARF in clinical transplantation. [ 19 20 ]…”

Section: Discussionmentioning

confidence: 99%

Preventive role of endothelin antagonist on kidney ischemia: Reperfusion injury in male and female rats

et al. 2015

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“…The ET concentration in the preservation solution after a long period of cold ischaemia has been shown to be increased [18] and elevated ET plasma levels have also been found in transplant recipients suffering from acute tubular necrosis [19]. In addition to the elevated levels of plasma ET, Buyukgebiz et al [20] reported an increase in the concentration of some markers for tissue injury such as lipid peroxidation and protein oxidation products in the renal tissue following cold I/R injury.…”

Section: Introductionmentioning

confidence: 98%

“…The involvement of ET in cold I/R injury in kidney transplantation has, however, been established [18][19][20][21]. The ET concentration in the preservation solution after a long period of cold ischaemia has been shown to be increased [18] and elevated ET plasma levels have also been found in transplant recipients suffering from acute tubular necrosis [19].…”

Section: Introductionmentioning

confidence: 99%

The Role of Endothelin inEarly Renal Cortical Reperfusionin Renal Transplantation

Hammad¹,

Davis²,

Zhang³

et al. 2000

Eur Surg Res

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The role of specific endothelin receptors in the early renal reperfusion and long-term survival in renal transplantation was investigated in Lewis rats. Left renal transplantation was performed following 2 h cold ischaemia without and with ET_A receptor antagonism and following 16 h cold ischaemia with no treatment, with ET_A receptor antagonism and with ET_B receptor antagonism. The ET_A and ET_B receptor antagonists, BQ-610 and A-192621 respectively, were added to the preservation solution. Renal cortical perfusion (RCP) was measured postoperatively using laser Doppler flowmetry. All rats in the 2-hour groups survived for 15 days. Animals in the untreated 16-hour group or in the A-192621-treated group died between days 3 and 6 after surgery. Fifty percent of the rats in the 16-hour and BQ-610-treated group died between days 4 and 7 after surgery while the other 50% survived for 15 days. Survival rates correlated well with both the postoperative serum creatinine and the recovery of RCP. We conclude that addition of an ET_A receptor antagonist to the preservation solution improves renal reperfusion and long-term survival following prolonged ischaemia, whereas ET_B receptor antagonism does neither.

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Assessment of Preservation Induced Reperfusion Injury via Intraoperative Renal Transplant Blood Flow and Endothelin Concentration Studies

et al. 1997

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Possible Involvement of Endothelin in Posttransplant Acute Tubular Necrosis. I

Cited by 9 publications

References 0 publications

Preventive role of endothelin antagonist on kidney ischemia: Reperfusion injury in male and female rats

Preventive role of endothelin antagonist on kidney ischemia: Reperfusion injury in male and female rats

The Role of Endothelin inEarly Renal Cortical Reperfusionin Renal Transplantation

Assessment of Preservation Induced Reperfusion Injury via Intraoperative Renal Transplant Blood Flow and Endothelin Concentration Studies

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