Possible Involvement of Endothelin in Posttransplant Acute Tubular Necrosis. Ii

Yamada, Katsushi; Hishikawa, Etsuo; Kashiwabara, Hidehiko; Sakamoto, Kaoru; Yokoyama, Takeo

doi:10.1097/00007890-199404000-00030

Cited by 4 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previously, we demonstrated that ET A receptor antagonist BQ-123, abolished the deleterious effects of I/R injury on lipid and protein structures in kidney grafts [6]. Yamada et al [52] pointed out that plasma immunoreactive ET levels and renal cortical and medullary ET contents significantly increased with time after reperfusion injury. In this study, the renal vein ET-1,2 concentrations increased significantly in Groups II and III.…”

Section: Discussionmentioning

confidence: 77%

“…The effects of ET-1 in the kidney include an increase in renal vascular resistance, a reduction of renal blood flow and various effects on the glomerular filtration rate [49]. ET also plays a crucial role in acute renal failure [47,52]. Previously, we demonstrated that ET A receptor antagonist BQ-123, abolished the deleterious effects of I/R injury on lipid and protein structures in kidney grafts [6].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The effects of thromboxane synthase inhibition on reperfusion injury and endothelin-1,2 levels in allograft kidney transplantation in rats

et al. 1998

View full text Add to dashboard Cite

Thromboxane A2 is a proaggregative vasoconstrictor that is synthesized and released in reperfusion injury. We aimed to investigate the effects of thromboxane synthase inhibitor, UK 38485, on endothelin-1,2 (ET) response of the renal endothelium and lipid peroxidation and protein oxidation in the early period of kidney transplantation. Four groups (n=8 in group IV and n=10 in the others) [corrected] of Sprague-Dawley rats were designed as Group I (sham nephrectomy), Group II (autotransplantation), Group III (allotransplantation) and Group IV (allotransplantation group in which the allografts were perfused with UK 38485. All subjects underwent right nephrectomy after transplantation. The grafts were flushed with 4 ml of ice-cold Ringer's lactate and in Group IV 10 microg of UK 38485 was added into the solution for each kidney. In allotransplantation groups, the kidneys were harvested from allogeneic white Wistar albino rats. The kidney grafts were allowed 120 min of reperfusion after 40 min of cold ischemic period. ET-1,2 plasma concentrations in the renal vein blood and diene conjugates (DC), hydroxyalkanals (HAA), hydroxyalkenals (HAE) and malondialdehyde (MDA) levels as the products of lipid peroxidation, protein carbonyls and protein sulfhydryls as the indicators of protein oxidation were analyzed in kidney tissue. Plasma ET-1,2 concentrations increased significantly in Group II and Group III (P<0.01) when compared to Group I but decreased in Group IV in comparison with Group III (P<0.05). DC, HAA, HAE and MDA levels increased in Groups II and III (P<0.001). Significant protein oxidation occurred only in Group III (P<0.01). Perfusion of the allografts with UK 38485 prevented lipid peroxidation and protein oxidation in Group IV. Histopathological changes were mild in the last group. We concluded that, in kidney transplantation, local administration of UK 38485 has cytopreservative effects on the allografts and this effect can be related to ET-1,2 concentrations.

show abstract

Section: Discussionmentioning

confidence: 77%

Section: Discussionmentioning

confidence: 99%

The effects of thromboxane synthase inhibition on reperfusion injury and endothelin-1,2 levels in allograft kidney transplantation in rats

et al. 1998

View full text Add to dashboard Cite

show abstract

“…In the literature there are conflicting reports about the correlation of these parameters with plasma ET levels. While Yamada et al [16] found that plasma ET levels correlated positively with serum creatinine concentrations, Koyama et al [12] and Niwa et al [15] were not able to find this correlation. Blood pressure may be one of the important factors related to plasma ET concentrations.…”

Section: Discussionmentioning

confidence: 94%

Acute changes in endothelin after hemodialysis in children

Noyan

Anarat

Anarat³

et al. 1998

Pediatric Nephrology

View full text Add to dashboard Cite

The purpose of this study was to investigate the acute changes in endothelin (ET) levels immediately after hemodialysis and to determine whether these changes vary with the use of different membranes and hemodialysis solutions. Ten children were included in the study. Three different hemodialysis sessions were performed on all patients: session 1, acetate-based dialysate and polycarbonate membrane; session 2, bicarbonate-based dialysate and polycarbonate membrane; session 3, acetate-based dialysate and polysulfone membrane. In all cases blood samples were obtained before and after dialysis. Pre- and post-hemodialysis ET levels of the patients with acetate-based dialysate and polycarbonate membrane were 33.68 +/- 11.51 pg/ml and 28.27 +/- 12.85 pg/ml, respectively. The fall in ET levels after this session was statistically significant (P = 0.015). We did not observe a statistically significant change in ET levels in the other sessions. Post-dialysis mean arterial pressure values were significantly lower than the pre-dialysis values in all three dialysis sessions (P < 0.01). A positive correlation was observed between plasma ET levels and blood urea nitrogen and serum potassium; a negative correlation was observed between plasma ET levels and hematocrit.

show abstract