Possible Involvement of Cyclic Amp in Inflammation Induced by a Surfactant

Abstract

Abstract-Alkyl d1 meth vlbenzylammonium chloride (alkyl-DBAC), a cationic sur factant, produces acute exudative inflammation accompanied by an enhancement of energy metabolism. The mechanism of metabolic changes, consequently the cyclic AMP level and the effects of certain drugs were determined in the gastrocnemius muscles of rats in which acute exudative inflammation had been induced by intramuscular injections of alkyl-DBAC.A transient increase in the cyclic AMP level was noted at 15 to 30 minutes after the injection of alkyl-DBAC, and this elevation was antago nized by chlorpromazine, diphenhydramine, promethazine, aspirin and indomethacin. The time course of increasing tendency in the cyclic AMP level after the injection of histamine closely paralleled that of alkyl-DBAC.These results suggest that cyclic AMP may be involved in the metabolic changes with inflammation induced by alkyl DBAC.

Clinical Science

“…8,9 Since inflamed gingiva of patients with chronic periodontal disease was found to contain 20-fold higher values of PGE2 levels A preliminary report was presented on this research at the Fourth International Prostaglandin Conference in Washington, D.C., in May, 1979. 674 than normal gingiva,10 and since there are no reports in the literature on levels of cAMP in gingival tissues, it was thought of great interest to study the relationship between gingival inflammation and the level of endogenous cAMP.…”