Possible involvement of a noradrenergic area of the amygdala with stereotyped behaviour

Costall, B.; Naylor, R.J.

doi:10.1016/0024-3205(72)90277-9

Cited by 33 publications

(8 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Involvement of NE in the pro duction of the above-mentioned behavior is supported by the finding that lesions of the NE-innervated lateral amygdaloid nucleus have been found to abolish apomorphineinduced compulsive gnawing [74], On the other hand, the twofold greater potency of dextroamphetamine compared with that of L-amphetamine in inducing gnawing behav ior led Taylor and Snyder [79] to believe in a limited involvement of NE in producing this effect. In addition, it is reported that admin istration of diethyldithiocarbamate, which blocks the enzyme dopamine (J-hydroxylase.…”

Section: Amine Imbalance Theorymentioning

confidence: 97%

“…Dopamine-2 recep tors are activated by apomorphine and se lectively inhibited by haloperidol while do pamine-1 receptors are selectively activated by DPI and inhibited by ergometrine. They also noted that GABA suppresses the be havioral effects induced by dopamine or apomorphine within the dopamine-2 area in contrast to picrotoxin which suppresses the effects triggered by haloperidol [74], Prange et al [75] developed the hypoth esis that an amine imbalance in the basal ganglia might account for TD. They pro posed that the preponderance of indolamines (serotonin) in the basal ganglia caused hypertonicity and hypokinesia while the preponderance of catecholamines cause dys kinesia and hypotonicity.…”

Section: Two Receptor Theory>mentioning

confidence: 99%

See 1 more Smart Citation

Current Psychopathological Theories of Tardive Dyskinesia and Their Implications for Future Research

Ananth¹

1982

Neuropsychobiology

View full text Add to dashboard Cite

An understanding of pathophysiology is essential for establishing an etiological relationship between the neuroleptics and tardive dyskinesia, for elucidating specific treatment methods and perhaps for synthesizing new neuroleptics which do not produce this side effect. Our current knowledge has been derived from clues obtained by drug-related factors, therapeutic agents assumed to improve tardive dyskinesia and by neuropathological findings. Among the many theories, dopaminergic hypersensitivity is the most favored and yet unproven. At present the etiology of tardive dyskinesia may be related to the interaction between the exogenous drugs and the endogenous predisposition, the nature of which is so far elusive.

show abstract

Section: Amine Imbalance Theorymentioning

confidence: 97%

Section: Two Receptor Theory>mentioning

confidence: 99%

Current Psychopathological Theories of Tardive Dyskinesia and Their Implications for Future Research

Ananth¹

1982

Neuropsychobiology

View full text Add to dashboard Cite

show abstract

“…D-Amphetamine (2.5mg/kg) was given 30min after ROX injection, apomorphine (0.5mg/kg) lh after ROX injection. The intensity of stereotyped activities was assessed according to an arbitrary 4-point scale (0 -normal, 1 -periodic sniffing, 2 -continuous sniffing, 3 -licking, 4 -gnawing and biting (a modified method of Costall and Naylor, 1972). Stereotypy was evaluated at 10-minute intervals for 2h in the D-amphetamine test (measurements were started 30min after D-amphetamine injection) or for lh in the apomorphine test (measurements were started 10min after apomorphine injection).…”

Section: D-amphetamine-and Apomorphine-induced Stereotypy In Ratsmentioning

confidence: 99%

Roxindole, a potential antidepressant I. Effect on the dopamine system

Kołodziejczyk

Rogóż

et al. 1996

J. Neural Transmission

View full text Add to dashboard Cite

Roxindole (EMD 49980, 5-hydroxy-3-[4-(4-phenyl-1,2,3,6-tetrahydropyridyl(1))-butyl(1)]-indole mesylate), a selective dopamine autoreceptor agonist and a potential antipsychotic drug, shows a clinical antidepressant efficacy. The present paper examined the neuropharmacological profile of roxindole in rats (male Wistar) and mice (male Albino Swiss) in respect of its influence on dopamine system. Used in low doses, roxindole decreased the locomotor activity, but in higher ones it did not induce a locomotor hyperactivity or stereotypy. It antagonized the amphetamine-induced hyperlocomotion, the amphetamine- or apomorphine-induced stereotypy, apomorphine climbing behaviour and reserpine-induced akinesia. The quinpirole-induced hyperlocomotion was inhibited by roxindole. When given alone, the drug in question, did not induce the catalepsy, but antagonized the catalepsy induced by haloperidol, spiperone and fluphenazine. The immobility time in the forced swimming test was reduced. Like typical antidepressants, roxindole given repeatedly (twice daily, 14 days) increased the hyperlocomotion induced by D-amphetamine. The results described above indicate that roxindole may have an antidepressant and antiparkinsonian activity and should be devoid of extrapyramidal side-effects.

show abstract

“…Symptoms were recorded using a 4-point scale of Costall and Naylor (1972), based on sniffing, licking and biting. The stereotypy was recorded for 1 h at 5-rain intervals.…”

Section: Apomorphine-induced Sterotypy In Ratsmentioning

confidence: 99%

Some central pharmacological effects of the calcium channel antagonist flunarizine

Czyrak

Mogilnicka

1991

J. Neural Transmission

View full text Add to dashboard Cite

Our earlier studies showed that dihydropyridine calcium channel antagonists have some central pharmacological effects. Flunarizine is considered to be a calcium channel antagonist; therefore this study was aimed at investigating the effect of flunarizine (given in single doses of 5, 10 and 20 mg/kg p.o.) in behavioural models in which calcium channel antagonists of the dihydropyridine type were previously studied. Flunarizine inhibited the apomorphine-induced stereotypy and yawning behaviour in rats. It decreased the hypothermia induced by a low dose of apomorphine in mice, but not that one induced by high dose of it. The quinpirole-induced hypothermia was also reduced. In the tests used for evaluation of the effect on the serotonergic system, flunarizine decreased the 5-HTP-induced head twitches and partly antagonized the fenfluramine- and quipazine-induced hyperthermias (at a high ambient temperature). In the forced swimming test flunarizine was inactive in mice and rats. The obtained results indicate that flunarizine exerts central antagonistic effects on the dopaminergic and serotonergic systems and has no antidepressant activity. Flunarizine differs from calcium channel antagonists of the dihydropyridine type, which have no dopamine-antagonistic activity and show anti-depressant-like properties.

show abstract

Possible involvement of a noradrenergic area of the amygdala with stereotyped behaviour

Cited by 33 publications

References 10 publications

Current Psychopathological Theories of Tardive Dyskinesia and Their Implications for Future Research

Current Psychopathological Theories of Tardive Dyskinesia and Their Implications for Future Research

Roxindole, a potential antidepressant I. Effect on the dopamine system

Some central pharmacological effects of the calcium channel antagonist flunarizine

Contact Info

Product

Resources

About