Possible interaction of fluoroquinolones with the benzodiazepine‐GABAA‐ receptor complex.

Unseld, E.; Ziegler, G.; Gemeinhardt, A; Janssen, Ulf; Klotz, Ulrich

doi:10.1111/j.1365-2125.1990.tb03744.x

Cited by 61 publications

(30 citation statements)

References 26 publications

(16 reference statements)

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“…2 Fluoroquinolones have also been found to inhibit benzodiazepine receptor binding. 3 The results of this small study seem to confirm that adverse reactions to fluoroquinolones occur more frequently in the benzodiazepinedependent population than the 1-4% seen in the general public and may be severe.…”

Section: British Journal Of General Practice May 2008supporting

confidence: 67%

Correction

2008

Br J Gen Pract

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Section: British Journal Of General Practice May 2008supporting

confidence: 67%

Correction

2008

Br J Gen Pract

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“…[13] Antagonistic effects at the benzodiazepine-GABA receptor have been demonstrated. [14] These could be the mechanisms involved in the pathogenesis of dystonia caused by fl uoroquinolones.…”

Section: Discussionmentioning

confidence: 99%

A probable association of acute dystonia with gemifloxacin administration

Sharma¹,

Aggarwal²,

Sharma³

et al. 2009

Indian J Med Sci

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“…Inotropic medications can affect sleep through their effects on adrenergic receptors. Beta blockers, which (48). Although all of these variables may contribute to the poor sleep of these patients, their importance lies in the fact that they are potentially modifiable.…”

Section: Risk Factors For Icu Sleep Deprivationmentioning

confidence: 99%

Sleep in the Intensive Care Unit

Pisani

Friese

Gehlbach

et al. 2015

Am J Respir Crit Care Med

300

253

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Sleep is an important physiologic process, and lack of sleep is associated with a host of adverse outcomes. Basic and clinical research has documented the important role circadian rhythm plays in biologic function. Critical illness is a time of extreme vulnerability for patients, and the important role sleep may play in recovery for intensive care unit (ICU) patients is just beginning to be explored. This concise clinical review focuses on the current state of research examining sleep in critical illness. We discuss sleep and circadian rhythm abnormalities that occur in ICU patients and the challenges to measuring alterations in circadian rhythm in critical illness and review methods to measure sleep in the ICU, including polysomnography, actigraphy, and questionnaires. We discuss data on the impact of potentially modifiable disruptors to patient sleep, such as noise, light, and patient care activities, and report on potential methods to improve sleep in the setting of critical illness. Finally, we review the latest literature on sleep disturbances that persist or develop after critical illness.

show abstract

Possible interaction of fluoroquinolones with the benzodiazepine‐GABAA‐ receptor complex.

Cited by 61 publications

References 26 publications

Correction

Correction

A probable association of acute dystonia with gemifloxacin administration

Sleep in the Intensive Care Unit

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