Possible Interaction Between Muscle Relaxants and the Kallikrein-Trypsin Inactivator “Trasylol”

Aprotinin

“…However, re-paralysis has been reported when aprotinin was used after operations during which suxamethonium had been given alone or in combination with normal doses of D-tubocurarine [77].…”

Antifibrinolytics in orthotopic liver transplantation: Current status and controversies

“…Rapid injection of aprotinin may cause histamine release leading to hypotension 18. A possible potentiation of muscle relaxants (suxamethonium and tubocurarine) by aprotinin was published in a case report 45…”

Drug‐Induced Neuromuscular Blockade and Myasthenia Gravis

“…These agents include trimetha~han,4~ procaine,7l lid~caine,~~ magnesium,72 o x y t o c in, 7 3 a n d a p r o ti nin . 45 Trim e t h a p h a n caused two cases of postoperative apnea lasting 2-17 48 It also was associated with four cases of respiratory failure, possibly with infusion rates of at least 9 mg/minute (3/4 patient^).^^ Procaine and lidocaine prolonged apnea up to 7 minutes in a dose-dependent manner (1-36 mg/kg) when administered together with succinylcholine i n 10 patients receiving electroconvulsive therapy. 71 Magnesium may block presynaptic neuromuscular transmission by interfering with calcium-mediated acetylcholine release.72 Magnesium potentiated the effects of neuromuscular-blocking agents,72 aggravated Lambert-Eaton ~y n d r o m e ,~ and interacted with aminoglycosides to evoke neuromuscular b l~c k a d e .~ Oxytocin delayed recovery from suxamethonium in five patients and experimentally extended neuromuscular blockade of suxamethonium in six o t h e r~.~ Aprotinin was implicated as causing apnea i n three patients receiving general anesthesia and muscle relaxants.…”