Possible Influence of Glutathione S -Transferase GSTT1 Null Genotype on Age of Onset of Sporadic Colorectal Adenocarcinoma

Nascimento, Helvia; Coy, Cláudio Saddy Rodrigues; Teori, Maria T.; Boin, I.F.S.F.; Góes, Juvenal Ricardo Navarro; Costa, Fernando Ferreira; Lima, Carmen S. P.

doi:10.1007/s10350-004-6591-4

Cited by 23 publications

(20 citation statements)

References 34 publications

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“…We found no association between GSTT1 status and CRC. A number of studies have shown the GSTT1 null genotype to be associated with increased CRC [4,20,21,22,23]. However, other studies have failed to replicate this association [24,25,26,27,28].…”

Section: Discussionmentioning

confidence: 99%

Polymorphisms of biotransforming enzymes (GSTs) and their association with colorectal cancer in the Slovak population

Matáková¹,

Sivoňová²,

Halašová³

et al. 2009

neo

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The aim of present study was to summarize the results of a case-control study focused on genetic polymorphisms of selected Phase II metabolizing enzymes (GSTM1, T1, P1) and to investigate the association of these polymorphisms with the colorectal cancer risk among the Slovak population.A case-control study with 183 colorectal cancer cases and 422 controls was conducted. DNA was extracted from peripheral blood leukocytes, and the polymorphisms of GSTM1, GSTT1 and GSTP1 enzymes were determined by PCR-based methods. Association between specific genotypes and the development of colorectal cancer were examined using logistic regression analysis to calculate odds ratios (OR) and 95% confidence intervals (CI).The GSTP1 val/val genotype (OR=2.1, 95%CI: 1.1 -4.0, χ 2 = 0.28 and P = 0.0025) was associated with an elevated risk. The statistically significant correlation was found also for the combined genotypes of GSTM1 null and GSTP1 valine homozygosity (OR = 2.7, 95% CI: 1.1-6.1, χ 2 = 4.5 and P = 0.03). The genotype of certain metabolising enzymes affects the risk for colorectal cancer. This effect is also important when certain allelic combinations are studied. In the near future, individual risk assessment may be reached by further increasing the number of studies of polymorphisms, combining them with the traditional epidemiological risk factor.

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Section: Discussionmentioning

confidence: 99%

Polymorphisms of biotransforming enzymes (GSTs) and their association with colorectal cancer in the Slovak population

Matáková¹,

Sivoňová²,

Halašová³

et al. 2009

neo

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“…Theoretically early onset of lung cancer may have well built genetic component in its pathology than is the case for lung cancer at older ages, and many studies have reported GST gene polymorphism have strongly associated with cancer risk at younger ages (16)(17)(18).…”

Section: Introductionmentioning

confidence: 99%

Comparative study of GST polymorphism in relation to age in COPD and lung cancer

Shukla

Kant²,

Mittal³

et al. 2013

Tuberk Toraks

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ÖZET KOAH ve akciğer kanserinde yaşla ilişkili olarak GST polimorfizmi karşılaştırmalı çalışma (OR= 1.87; 95%; p= 0.002). GSTM1 null akciğer kanseriyle ilişkili bulunmadı. Alt grup analizinde GSTM1 null polimorfizmi [46][47][48][49][50][51][52][53][54][55][56][57][58][59][60][61][62][63][64][65] OR= 3.20; 95%; p= 0.001), akciğer kanserli hastalar ile kontrol arasında aynı yaş grubunda fark yoktu (55.6%/44.4% OR= 1.07; p= 0.774

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“…Differential expression from the drug metabolism gene array includes functional gene groups related to Drug transporter such as metallothioneins and P-glycoprotein family; Phase I metabolizing enzymes such as cytochrome P450 (CYPs) and Phase II metabolizing enzymes such as acetyltransferases, epoxide hydrolases, glutathione Stransferases (GSTs), methyltransferases, sulfotransferases and UDP glycosyltransferases (14)(15)(16)(17)(18). Metallothionein (MT) is a sulfhydryl-and cysteine-rich protein found in microorganisms, plants and all invertebrate and vertebrate animals (14).…”

Section: Introductionmentioning

confidence: 99%

“…Mammalian cytosolic GSTs form a super family consisting of four distinct families, named α, μ, π and θ. The μ (GSTM1) and θ (GSTT1) members of the GST multigene family are candidate cancer susceptibility genes because of their ability to regulate the conjugation of carcinogenic compounds to excretable hydrophilic metabolites (16)(17)(18). Worldwide, organophosphate insecticides result in numerous poisonings each year.…”

Section: Introductionmentioning

confidence: 99%

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Human drug metabolism genes in parathion-and estrogen-treated breast cells

Calaf

Roy²

2007

Int J Mol Med

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Abstract. Environmental chemicals may be involved in the etiology of breast cancer. Among them, organophosphorous compounds are the most widely used pesticides because of their extensive use in agriculture, medicine and industry. The risk of breast cancer is associated with prolonged exposure to female hormones and is attributed to estrogen since prolonged stimulation by steroid hormones may increase cell division. The aim of the present study was to identify the differentially expressed genes encoding enzymes that are important to drug transport and metabolism in parathion-and estrogen-treated human breast epithelial cell lines using cDNA microarrays. MCF-l0F, an immortalized human breast epithelial cell line was treated with parathion and estrogen, either alone or in combination, and malignant cells were developed through a series of sequential steps. Differential expression from the drug metabolism gene array showed that 17 genes were found to be altered either by parathion or estrogen alone, or the combination of both. Among the genes altered by parathion in comparison to the control were CHST5, CHST6 and CHST7 (sulfotransferases); CYP2F1, CYP3A7 and CYP4F3 (CYPs); GSTP1, GSTT2 and MGST1 (GSTs); MT1X (metallothionein); TPMT (methyltransferase); UGT1A1 and UGT2B (UDP glycosyltransferases). The same genes were down-regulated in estrogen alone including several metallothioneins (MT1A, MT1E, MT1H, MT1L and MT2A). The combination of parathion and estrogen induced downregulation of three sulfotransferases, CYP2F1 and CYP4F3, MGST1, all metallothioneins and TPMT genes. There was no change in CYP3A7, GSTP1, GSTT2, UGT1A1 and UGT2B genes in the presence of both substances. It can be concluded from this study that organophosphorous pesticides such as parathion in the presence of estradiol induced changes in human drug metabolism gene expression in breast cells.

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Possible Influence of Glutathione S -Transferase GSTT1 Null Genotype on Age of Onset of Sporadic Colorectal Adenocarcinoma

Cited by 23 publications

References 34 publications

Polymorphisms of biotransforming enzymes (GSTs) and their association with colorectal cancer in the Slovak population

Polymorphisms of biotransforming enzymes (GSTs) and their association with colorectal cancer in the Slovak population

Comparative study of GST polymorphism in relation to age in COPD and lung cancer

Human drug metabolism genes in parathion-and estrogen-treated breast cells

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