Possible Induction of Antinuclear Antibodies by Isoniazid

Induction of antinuclear antibodies by ultraviolet irradiation.

“…The observed female preponderance is in accordance with that found in idiopathic autoimmune disease and has also been observed in iatrogenic autoimmune phenomena (Cannat and Seligmann, 1968). …”

Antinuclear factor in rapid and slow acetylator patients treated with isoniazid.

“…(The tuberculosis patients had a mean age of 45 and a range of 12 to 76 years.) The incidence of ANF positivity in the patients treated for tuberculosis by Cannat and Seligmann (1966) was 20%, and Alarcon-Segovia (1969) states: 'We have recently confirmed such higher incidence of antinuclear antibodies in isoniazidtreated tuberculosis patients. ' Cannat and Seligmann (1968) were able to demonstrate the experimental induction of ANF by isoniazid in mice.…”

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It has been observed that tuberculous patients who had been treated with isoniazid exhibited positive antinuclear factor (ANF) tests more commonly than controls (Cannat and Seligmann, 1966). ANF can be considered a forerunner of the drug-induced systemic lupus erythematosus syndrome (Alarcon-Segovia, 1969).

Both isoniazid and hydrallazine have been demonstrated to be polymorphically acetylated in man (Evans, 1968).

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Differences between Type I Autoimmune Inhibitors of Fibrin Stabilization in Two Patients with Severe Hemorrhagic Disorder

“…Appearance of the circulating inhibitors in the two patients may well have been drug related. Both penicillin and isoniazid are known for their reactivities with proteins (27)(28)(29)(30) and also for their autoimmunizing side effects (31)(32)(33). Thus, the possibility exists that the covalent modification of Factor XIII by these drugs may have led to a breakdown of immunological tolerance to the native coagulation factor itself.…”