Possible Improvement of the Sagittal Spinopelvic Alignment and Balance through “Locomotion Training” Exercises in Patients with “Locomotive Syndrome”: A Literature Review

Yurube, Takashi; Ito, Masaaki; Takeoka, Toru; Watanabe, Nobuyoshi; Inaoka, H; Kakutani, Kenichiro; Kuroda, R.; Nishida, Kotaro

doi:10.1155/2019/6496901

Cited by 17 publications

(13 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Kazzman et al 21) reported that a spine-strengthening exercise with postural training for older adults reduced spinal hyperkyphosis and improved the patients' self-image, including increased satisfaction with their appearance. The term "locomotive syndrome" was proposed by the Japanese Orthopedic Association in 2007 as a condition of reduced mobility due to the impairment of locomotive organs; many reports have revealed the effectiveness of physical intervention for elderly people in preventing the locomotive syndrome and the decline in activities of daily living 22,23) .…”

Section: Discussionmentioning

confidence: 99%

Age-Related Progression of Degenerative Lumbar Kyphoscoliosis: A Retrospective Study

Ishihara¹,

Morishita²,

Kanzaki

et al. 2020

Spine Surg Relat Res

View full text Add to dashboard Cite

Introduction:Degenerative lumbar kyphoscoliosis is a serious clinical condition that affects activities of daily living. This study aimed to investigate the age-related progression of nonoperative degenerative lumbar kyphoscoliosis, to clarify its final state in elderly people, and to identify factors associated with its progression.Methods: This retrospective longitudinal study included 115 nonoperative cases (mean age at first consultation, 70.9 years; range, 50-89 years). All were followed up for >6 years. The analysis included changes between initial and latest measurements in the coronal parameters (Cobb angle, L4 tilt angle, intervertebral angle, lateral spondylolisthesis, and C7-central sacral vertical line) and sagittal parameters (thoracic kyphosis, lumbar lordosis, pelvic incidence, pelvic tilt, sacral slope, sagittal vertical axis, and vertebral wedging rate). Factors in scoliosis progression were investigated by analyzing the correlations between the initial parameter values and the increase in Cobb angle. Results:Changes in the coronal parameters increased with age from 50s to 70s but decreased significantly in those aged 80s. Sagittal parameters increased by the age group, accelerating in those aged 80s, with the progression of vertebral wedging. In patients aged 50s-70s, the increase in Cobb angle correlated significantly with the initial Cobb angle, L4 tilt angle, and L4/L5 intervertebral angle.However, in the cases without initial scoliosis, the increase in Cobb angle correlated significantly only with the L4 tilt angle. There were no significant differences in any parameter according to the use of a trunk brace or medication for osteoporosis. Conclusions: L4 tilt angle is an important factor in the progression of degenerative scoliosis. The progression of scoliosis gradually ends after the age of 80 years with the decreasing variation of L4 tilt * * % *

show abstract

Section: Discussionmentioning

confidence: 99%

Age-Related Progression of Degenerative Lumbar Kyphoscoliosis: A Retrospective Study

Ishihara¹,

Morishita²,

Kanzaki

et al. 2020

Spine Surg Relat Res

View full text Add to dashboard Cite

show abstract

“…Yurube et al. also reported two cases of improved SVA by exercise training, suggesting that strengthening of the back and lower extremity muscles, in addition to their improved flexibility, can improve sagittal spinal alignment [ 27 ]. Moreover, locomotion training has been reported to reduce fall rates and improve SVA [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

“…Hori et al investigated the relationship between trunk muscle strength and SVA, and suggested that lower muscle strength in the trunk was associated with a higher SVA [26]. Yurube et al also reported two cases of improved SVA by exercise training, suggesting that strengthening of the back and lower extremity muscles, in addition to their improved flexibility, can improve sagittal spinal alignment [27]. Moreover, locomotion training has been reported to reduce fall rates and improve SVA [28].…”

Section: Discussionmentioning

confidence: 99%

Characteristics of sagittal spine alignment in female patients with distal radius fractures due to fall

Kaneko

Naïto

Nagura

et al. 2020

Heliyon

View full text Add to dashboard Cite

Objectives Distal radius fractures occur due to reflex clasp when falling. Recently, attention has been focused on the strong relationship between sagittal spine alignment and falls. Therefore, we investigated the parameters of sagittal spinal alignment in distal radius fractures in female patients. Patients and methods The subjects were group D: 28 female patients with distal radius fractures aged 50 years or older (mean age: 69.3 years), and group C: 26 healthy female patients without a history of fragility fractures (mean age: 70.5 years). Height, body weight, and body mass index (BMI) were measured as physical indices. As parameters of sagittal spinal alignment, the sagittal vertical axis (SVA), pelvic tilt (PT), pelvic incidence (PI), sacral slope (SS), lumber lordosis (LL), and thoracic kyphosis (TK) were measured on lateral whole-spine plain radiographs in a standing position. The measured physical indices and sagittal spinal alignment parameters were compared between groups. Results Height, weight, and BMI did not differ significantly between the two groups. Among the sagittal spinal alignment parameters, PT, PI, SS, LL, and TK did not differ significantly between groups, whereas SVA was significantly higher in group D than in group C (P < 0.05). Conclusion In this study, SVA was significantly higher in group D than in group C. As SVA increased, the center of gravity of the body shifts forward, which can cause the body to lose balance and fall. This study suggested that an increase in SVA is associated with distal radius fractures.

show abstract

“…4 Furthermore, IDD is associated with neurological impairments including radiculopathy, myelopathy, and paralysis 3 and impaired daily activities of the elderly. 5 Biochemically, IDD is characterized by the loss of extracellular proteoglycan matrix due to increased catabolism from persistent matrix homeostatic imbalance. 6 Matrix degradation is a consequence of increased activities of catabolic enzymes, including matrix metalloproteinases (MMPs) and a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTSs), and/or decreased activities of tissue inhibitors of metalloproteinases (TIMPs).…”

Section: Introductionmentioning

confidence: 99%

Rapamycin mitigates inflammation‐mediated disc matrix homeostatic imbalance by inhibiting mTORC1 and inducing autophagy through Akt activation

Yurube,

Buchser,

Zhang

et al. 2024

JOR Spine

Self Cite

View full text Add to dashboard Cite

BackgroundLow back pain is a global health problem that originated mainly from intervertebral disc degeneration (IDD). Autophagy, negatively regulated by the phosphatidylinositol 3‐kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) signaling pathway, prevents metabolic and degenerative diseases by removing and recycling damaged cellular components. Despite growing evidence that autophagy occurs in the intervertebral disc, the regulation of disc cellular autophagy is still poorly understood.MethodsAnnulus fibrosus (rAF) cell cultures derived from healthy female rabbit discs were used to test the effect of autophagy inhibition or activation on disc cell fate and matrix homeostasis. Specifically, different chemical inhibitors including rapamycin, 3‐methyladenine, MK‐2206, and PP242 were used to modulate activities of different proteins in the PI3K/Akt/mTOR signaling pathway to assess IL‐1β‐induced cellular senescence, apoptosis, and matrix homeostasis in rAF cells grown under nutrient‐poor culture condition.ResultsRapamycin, an inhibitor of mTOR complex 1 (mTORC1), reduced the phosphorylation of mTOR and its effector p70/S6K in rAF cell cultures. Rapamycin also induced autophagic flux as measured by increased expression of key autophagy markers, including LC3 puncta number, LC3‐II expression, and cytoplasmic HMGB1 intensity and decreased p62/SQSTM1 expression. As expected, IL‐1β stimulation promoted rAF cellular senescence, apoptosis, and matrix homeostatic imbalance with enhanced aggrecanolysis and MMP‐3 and MMP‐13 expression. Rapamycin treatment effectively mitigated IL‐1β‐mediated inflammatory stress changes, but these alleviating effects of rapamycin were abrogated by chemical inhibition of Akt and mTOR complex 2 (mTORC2).ConclusionsThese findings suggest that rapamycin blunts adverse effects of inflammation on disc cells by inhibiting mTORC1 to induce autophagy through the PI3K/Akt/mTOR pathway that is dependent on Akt and mTORC2 activities. Hence, our findings identify autophagy, rapamycin, and PI3K/Akt/mTOR signaling as potential therapeutic targets for IDD treatment.

show abstract

Possible Improvement of the Sagittal Spinopelvic Alignment and Balance through “Locomotion Training” Exercises in Patients with “Locomotive Syndrome”: A Literature Review

Cited by 17 publications

References 47 publications

Age-Related Progression of Degenerative Lumbar Kyphoscoliosis: A Retrospective Study

Age-Related Progression of Degenerative Lumbar Kyphoscoliosis: A Retrospective Study

Characteristics of sagittal spine alignment in female patients with distal radius fractures due to fall

Rapamycin mitigates inflammation‐mediated disc matrix homeostatic imbalance by inhibiting mTORC1 and inducing autophagy through Akt activation

Contact Info

Product

Resources

About