Possible functional states of the enzyme of the sarcoplasmic calcium pump

In Silico Investigation into Cellular Mechanisms of Cardiac Alternans in Myocardial Ischemia

“…At the same time, the products MgADP, Pi, and H + are released. This reversible reaction is modeled by E1-E2 model [18, 19] which consisted of two conformational changes of Ca 2+ -binding sites.…”

“…The three-state model (Figure 1) is simplified from the E1-E2 model [18, 19] using rapid equilibrium assumption. In the positive direction, state S 1 transforms to S 2 via the hydrolysis of ATP.…”

“…Hydrolysis of MgATP and the release of MgADP/Pi occur in the positive direction during the transformation process. The reaction process is simplified from the E1-E2 model [18, 19]. …”

In silico study of the mechanisms of hypoxia and contractile dysfunction during ischemia and reperfusion of hiPSC cardiomyocytes

“…Considering rapid equilibrium assumptions applicable to physiological and ischemic conditions, Tran et al (2009) developed a lumped two-state thermodynamic model of SERCA based on the E1-E2 model of Ca 2+ transport in SERCA ( Makinose, 1973 ; Meis and Vianna, 1979 ), adding proton (H + )-binding kinetics to capture pH-dependence phenomena.…”