Possible Epileptogenic Effect of Mianserin

Tyrer, Peter; Steinberg, Bernhard; Watson, Betty S.

doi:10.1016/s0140-6736(79)92150-0

Cited by 8 publications

(1 citation statement)

References 9 publications

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“…In rabbits, both mianserin and maprotiline show convulsant activity, but at doses higher than those of amitriptyline or imipramine (Hughes & Radman, 1979). Clinically there have been a few reports of seizures following mianserin (Edwards, 1979;Tyrer et al, 1979) and up to August 1981, 45 reports of convulsions associated with the use of this drug had been received by the Committee on Safety of Medicines. In overdose, however, mianserin appears not to induce seizures.…”

Section: Convulsant Effects Of Antidepressant Drugsmentioning

confidence: 99%

Antidepressant drugs, convulsions and epilepsy.

Richens¹,

Nawishy²,

Trimble³

1983

Brit J Clinical Pharma

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1 Evidence concerning the convulsant effects of non-monoamine oxidase inhibitor antidepressant drugs has been reviewed. 2 Mianserin is convulsant in therapeutic doses but seizures have not been reported following overdose. 3 The convulsant effects of mianserin are probably no greater than for other non-monoamine oxidase inhibitor antidepressant drugs. 4 Enzyme-inducing anti-epileptic drugs can reduce the peak plasma concentration of mianserin and shorten its elimination half-life, probably by inducing its metabolism.

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Section: Convulsant Effects Of Antidepressant Drugsmentioning

confidence: 99%

Antidepressant drugs, convulsions and epilepsy.

Richens¹,

Nawishy²,

Trimble³

1983

Brit J Clinical Pharma

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Psychoactive Agents, Seizure Production, and Sudden Death in Epilepsy

Lipka

Lathers

1987

The Journal of Clinical Pharma

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Major tranquilizers as well as antidepressant agents have been associated with clinical seizures in patients administered these agents. The incidence of such seizures is generally low when these drugs are administered in therapeutic doses. However, administration of large doses of these agents has been associated with many cases of convulsion production. The effects that these drugs have on animal models of epilepsy have been examined. It appears that the phenothiazines act as convulsant agents at lower doses, whereas, at higher doses, they act as anticonvulsant drugs. Antidepressants, on the other hand, appear to exert an anticonvulsant effect at low doses and convulsant effects at high doses. The mechanism by which these agents alter the seizure threshold is not yet known. Clinically, drugs of lower seizure production potential should be substituted for those drugs with greater potential in treating epileptic patients for psychiatric ailments. The problem of sudden death in epileptic patients is one that must be confronted. Sudden death has most frequently been attributed to autonomic dysfunction and cardiac arrhythmia in these patients. The contribution of stress in sudden death production also must be taken into account. In addition, some psychoactive agents have been associated with sudden death as well as cardiac arrhythmia and seizure production. Thus, in light of the possible additivity of the factors involved in the production of sudden death, the administration of a psychoactive agent to an epileptic patient should be approached with caution. Those agents that do not alter cardiac rhythm or seizure threshold should be administered if a psychoactive agent is deemed necessary for the management of psychiatric illness in the epileptic patient.

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New antidepressant drugs and the seizure threshold

1980

Neuropharmacology

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Possible Epileptogenic Effect of Mianserin

Cited by 8 publications

References 9 publications

Antidepressant drugs, convulsions and epilepsy.

Antidepressant drugs, convulsions and epilepsy.

Psychoactive Agents, Seizure Production, and Sudden Death in Epilepsy

New antidepressant drugs and the seizure threshold

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