Possible effects of persistent organochlorinated pollutants cocktail on thyroid hormone levels and pituitary–thyroid interrelations

Langer, P; Kočan, Anton; Tajtáková, M; Rádiková, Žofia; Petrı́k, Ján; Koška, Juraj; Kšinantová, L; Imrich, Richard; Hučková, Miloslava; Chovancová, Jana; Drobná, Beata; Jursa, Stanislav; Bergman, Anders; Athanasiadou, María; Hovander, Lotta; Gašperíková, Daniela; Trnovec, T.; Seböková, E; Klimeš, I

doi:10.1016/j.chemosphere.2007.06.046

Cited by 42 publications

(34 citation statements)

References 37 publications

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“…The same is true for levels of dioxins, furans and dioxin-like PCBs [16], as well as for OH-and MeSO 2 -metabolites [17]. Moreover, in the population of this area increased thyroid volume, prevalence of thyroid antibodies, disruption of thyroid hormone level and pituitary-thyroid interrelations have been found [18][19][20][21][22]. More recently, an increase in adverse health signs has been reported in adults [23] as well as in newborns, infants and school children of this area, e.g.…”

Section: Introductionmentioning

confidence: 62%

High prevalence of prediabetes and diabetes in a population exposed to high levels of an organochlorine cocktail

et al. 2010

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Aims/hypothesis A heavily polluted area of Eastern Slovakia was targeted by the PCBRISK cross-sectional survey to search for possible links between environmental pollution and both prediabetes and diabetes. Methods Associations of serum levels of five persistent organic pollutants (POPs), namely polychlorinated biphenyls (PCBs), 2,2′-bis(4-chlorophenyl)-1,1-dichloroethylene (p,p′-DDE), 2,2′-bis(4-chlorophenyl)-1,1,1-trichloro-ethane (p,p′-DDT), hexachlorobenzene (HCB) and β-hexachlorocyclohexane (β-HCH), with prediabetes and diabetes were investigated in 2,047 adults. Diabetes and prediabetes were diagnosed by fasting plasma glucose in all participants and by OGTT in 1,220 compliant participants. Results Our population was stratified in terms of individual POPs quintiles and associations between environmental pollution, prediabetes and diabetes were investigated. Prevalence of prediabetes and diabetes increased in a dose-dependent manner, with individuals in upper quintiles of individual POPs showing striking increases in prevalence of prediabetes as shown by OR and 95% CI for PCBs (2.74; 1.92-3.90), DDE (1.86; 1.17-2.95), DDT (2.48; 1.77-3.48), HCB (1.86; 1.7-2.95) and β-HCH (1.97; 1.28-3.04). Interestingly, unlike PCBs, DDT and DDE, increased levels of HCB and β-HCH seemed not to be associated with increased prevalence of diabetes. Nevertheless, individuals in the 5th quintile of the variable expressing the cumulative effect of all five POPs (sum of orders) had a more than tripled prevalence of prediabetes and more than six times higher prevalence of diabetes when compared with the 1st referent quintile. Conclusions/interpretation Increasing serum concentrations of individual POPs considerably increased prevalence of prediabetes and diabetes in a dose-dependent manner. Interaction of industrial and agricultural pollutants in increasing prevalence of prediabetes or diabetes is likely.

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Section: Introductionmentioning

confidence: 62%

High prevalence of prediabetes and diabetes in a population exposed to high levels of an organochlorine cocktail

et al. 2010

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“…We examined the relationship of POPs to anti-thyroid peroxidase antibody (TPOAb), a biomarker of autoimmune disease [55, 56]. Autoantibodies to thyroid peroxidase can impair thyroid function [9].…”

Section: Resultsmentioning

confidence: 99%

“…PCB congeners were grouped according to chlorination and structure. TPOAb is a marker of thyroid dysfunction, and a risk factor for autoimmune disease, with a high predictive value [52–56]. Two protocols for the analysis of TPOAb levels were employed by our laboratory resulting in two different laboratory reference ranges.…”

Section: Discussionmentioning

confidence: 99%

Relationships of putative endocrine disruptors to human sexual maturation and thyroid activity in youth

Schell

Gallo

2010

Physiology & Behavior

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Endocrine disruption has become a significant human health concern, but is difficult to study outside of the laboratory for several reasons including the multiplicity of exposures, the difficulty in assessing each exposure, and the variety of possible outcomes among human populations. This review summarizes our studies of the relationships of measured persistent organic pollutants (PCBs, p,p′-DDE, HCB and mirex), and heavy metals (lead and mercury), to outcomes directly related to thyroid function and sexual maturation. These studies were conducted in a sample of Native American youth from the Akwesasne Mohawk community. The participants were first studied during puberty (10-16.9 years of age) and then at approximately 18 years of age. Results from these studies show that PCB levels are positively related to TSH and negatively to free T4. Further, these effects are conditioned by breastfeeding history. Anti-thyroid peroxidase antibody levels also are related to PCB levels suggesting elevated risk of autoimmune disease among the exposed. Earlier age at menarche is associated with higher PCB levels while risk of delay is associated with higher lead levels. Some evidence that the timing of exposure produces different effects is presented, and the level of exposure in the participants suggests that effects observed may be relevant to a considerable proportion of the US population. Further investigations are warranted to determine effect thresholds and mechanisms.

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“…Individuals having a mild, chronic controlled illness (e.g., rheumatic diseases, hypertension, diabetes, thyroid disorders, non-morbid obesity, allergy) were not excluded from the study. At enrollment, participants were given a physical examination by our field medical staff, and sociodemographic and medical questionnaires were completed (Langer 2010; Langer et al 2006, 2007a, 2007b, 2007c, 2008; Rádiková et al 2008; Ukropec et al 2010). …”

Section: Methodsmentioning

confidence: 99%

Relative Effect Potency Estimates of Dioxin-like Activity for Dioxins, Furans, and Dioxin-like PCBs in Adults Based on Two Thyroid Outcomes

Trnovec

Jusko

Šovčíková

et al. 2013

Environ Health Perspect

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Background: Toxic equivalency factors (TEFs) are an important component in the risk assessment of dioxin-like human exposures. At present, this concept is based mainly on in vivo animal experiments using oral dosage. Consequently, the current human TEFs derived from mammalian experiments are applicable only for exposure situations in which oral ingestion occurs. Nevertheless, these “intake” TEFs are commonly—but incorrectly—used by regulatory authorities to calculate “systemic” toxic equivalents (TEQs) based on human blood and tissue concentrations, which are used as biomarkers for either exposure or effect.Objectives: We sought to determine relative effect potencies (REPs) for systemic human concentrations of dioxin-like mixture components using thyroid volume or serum free thyroxine (FT4) concentration as the outcomes of interest.Methods: We used a benchmark concentration and a regression-based approach to compare the strength of association between each dioxin-like compound and the thyroid end points in 320 adults residing in an organochlorine-polluted area of eastern Slovakia.Results: REPs calculated from thyroid volume and FT4 were similar. The regression coefficient (β)-derived REP data from thyroid volume and FT4 level were correlated with the World Health Organization (WHO) TEF values (Spearman r = 0.69, p = 0.01 and r = 0.62, p = 0.03, respectively). The calculated REPs were mostly within the minimum and maximum values for in vivo REPs derived by other investigators.Conclusions: Our REPs calculated from thyroid end points realistically reflect human exposure scenarios because they are based on chronic, low-dose human exposures and on biomarkers reflecting body burden. Compared with previous results, our REPs suggest higher sensitivity to the effects of dioxin-like compounds.

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Possible effects of persistent organochlorinated pollutants cocktail on thyroid hormone levels and pituitary–thyroid interrelations

Cited by 42 publications

References 37 publications

High prevalence of prediabetes and diabetes in a population exposed to high levels of an organochlorine cocktail

High prevalence of prediabetes and diabetes in a population exposed to high levels of an organochlorine cocktail

Relationships of putative endocrine disruptors to human sexual maturation and thyroid activity in youth

Relative Effect Potency Estimates of Dioxin-like Activity for Dioxins, Furans, and Dioxin-like PCBs in Adults Based on Two Thyroid Outcomes

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