Possible Effects of Glyphosate on Mucorales Abundance in the Rumen of Dairy Cows in Germany

Schrödl, Wieland; Krüger, S.; Konstantinova-Müller, Theodora; Shehata, Awad A.; Rulff, R; Krüger, Monika

doi:10.1007/s00284-014-0656-y

Cited by 19 publications

(15 citation statements)

References 31 publications

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“…Residues of glyphosate and AMPA in plant products and water are taken up by animals and humans and largely (60-70%) excreted in their feces and urine (Bus, 2015;Faniband et al, 2021;Heymann et al, 2021;Niemann et al, 2015;von Soosten et al, 2016;FAO and WHO, 2016). Glyphosate was detected in the urine of up to 96% of farm animals, with a maximum of 164 μg/L (Krüger et al, 2014a;Krüger et al, 2014b;Schrödl et al, 2014). Glyphosate and AMPA were also found frequently in the urine of dogs and cats, at relatively high concentrations (34-111 μg/L) (Karthikraj and Kannan, 2019).…”

Section: Glyphosate Residues In Plant and Animal Productsmentioning

confidence: 99%

Indirect Effects of the Herbicide Glyphosate on Plant, Animal and Human Health Through its Effects on Microbial Communities

Bruggen

Finckh

et al. 2021

Front. Environ. Sci.

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The herbicide glyphosate interferes with the shikimate pathway in plants and in major groups of microorganisms impeding the production of aromatic amino acids. Glyphosate application on plants results in a slow death, accelerated by reduced resistance to root pathogens. Extensive glyphosate use has resulted in increasing residues in soil and waterways. Although direct glyphosate effects on animals are limited, major concerns have arisen about indirect harmful side effects. In this paper, we focus on indirect effects of sublethal concentrations of glyphosate on plant, animal and human health due to shifts in microbial community compositions in successive habitats. Research results of glyphosate effects on microbial communities in soil, rhizosphere and animal guts have been contradictory due to the different integration levels studied. Most glyphosate studies have tested short-term treatment effects on microbial biomass or general community composition at higher taxonomic levels in soil, rhizosphere or animal intestinal tracts, and found little effect. More detailed studies showed reductions in specific genera or species as well as biological processes after glyphosate application. Plant growth promoting rhizobacteria and beneficial intestinal bacteria often are negatively affected, while pathogenic bacteria and fungi are enhanced. Such shifts in microbial community composition have been implicated in enhanced susceptibility of plants to Fusarium and Rhizoctonia, of birds and mammals to toxic Clostridium and Salmonella species, and of bees to Serratia and Deformed Wing Virus. In animals and humans, glyphosate exposure and concentrations in urine have been associated with intestinal diseases and neurological as well as endocrine problems, but cause-effect relationships need to be determined in more detail. Nevertheless, outbreaks of several animal and plant diseases have been related to glyphosate accumulation in the environment. Long-term glyphosate effects have been underreported, and new standards will be needed for residues in plant and animal products and the environment.

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Section: Glyphosate Residues In Plant and Animal Productsmentioning

confidence: 99%

Indirect Effects of the Herbicide Glyphosate on Plant, Animal and Human Health Through its Effects on Microbial Communities

Bruggen

Finckh

et al. 2021

Front. Environ. Sci.

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“…Schrödl et al . () concluded from their investigations on four species of fungi a modulating effect of glyphosate on the fungal community in the rumen of dairy cows. However, they did not perform a controlled feeding study.…”

Section: Introductionmentioning

confidence: 99%

Investigations on the possible impact of a glyphosate-containing herbicide on ruminal metabolism and bacteriain vitroby means of the ‘Rumen Simulation Technique’

et al. 2016

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Aims: This study was performed in a well-established in vitro model to investigate whether the application of a glyphosate-containing herbicide might affect the bacterial communities and some biochemical parameters in a cow's rumen. Methods and Results: The test item was applied in two concentrations (high and low) for 5 days. In a second trial, fermentation vessels were inoculated with Clostridium sporogenes before the high dose was applied. Effluents were analysed by biochemical, microbiological and genetic methods. A marginal increase in short-chain fatty acid production and a reduction in NH 3 -N were observed. There were minor and rather equivocal changes in the composition of ruminal bacteria but no indications of a shift towards a more frequent abundance of pathogenic Clostridia species. Clostridium sporogenes counts declined consistently. Conclusions: No adverse effects of the herbicide on ruminal metabolism or composition of the bacterial communities could be detected. In particular, there was no evidence of a suspected stimulation of Clostridia growth. Significance and Impact of the Study: Antibiotic activity of glyphosate resulting in microbial imbalances has been postulated. In this exploratory study, however, intraruminal application of concentrations reflecting potential exposure of dairy cows or beef cattle did not exhibit significant effects on bacterial communities in a complex in vitro system. The low number of replicates (n = 3/dose) may leave some uncertainty.

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“…Numerous researchers have considered the toxicology of glyphosate (Funke, Han, Healy-Fried, Fischer, & Schönbrunn, 2006;Krüger, Shehata, Schrödl, & Rodloff, 2013;Schrödl et al, 2014 (Miftaul et al, 2020). Moreover, the addition of co-formulants to glyphosate causes some formulations to exhibit toxicity to humans and animals.…”

Section: Glyphosate Toxicologymentioning

confidence: 99%

Monsanto's Roundup verdicts portend liability for some pesticide health damages

Centner

2020

Agronomy Journal

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Three California juries have found that Monsanto should be liable for millions of dollars in non-economic losses to pesticide users and punitive damages, although the verdicts are on appeal. The plaintiffs in the lawsuits claimed Monsanto was negligent in failing to provide training on how to use Roundup and for not providing adequate warnings about the product's dangers. The punitive damage awards resulted from jurors finding that the defendant had engaged in malice, oppression, or fraud. In June 2020, Monsanto's owner Bayer reached an agreement to resolve approximately 125,000 Roundup product liability claims for US$10.1 billion. The verdicts and the proffered settlement suggest that pesticide products that unduly impair human health are not acceptable under American liability principles. Manufacturers need to design products that are reasonably safe and convey sufficient warning information to minimize damages to users and property. The placement of damage costs on product manufacturers is intended to encourage the development of safer pesticide products and the development of alternative non-chemical pest-control measures.

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Possible Effects of Glyphosate on Mucorales Abundance in the Rumen of Dairy Cows in Germany

Cited by 19 publications

References 31 publications

Indirect Effects of the Herbicide Glyphosate on Plant, Animal and Human Health Through its Effects on Microbial Communities

Indirect Effects of the Herbicide Glyphosate on Plant, Animal and Human Health Through its Effects on Microbial Communities

Investigations on the possible impact of a glyphosate-containing herbicide on ruminal metabolism and bacteriain vitroby means of the ‘Rumen Simulation Technique’

Monsanto's Roundup verdicts portend liability for some pesticide health damages

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