Possible effects of coronavurus infection (COVID-19) on the cardiovascular system

Ларина, В. Н.; Головко, М Г; Ларин, В. Г.

doi:10.24075/brsmu.2020.020

Cited by 6 publications

(1 citation statement)

References 33 publications

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“…This leads to downregulation of pulmonary ACE2, and subsequent dysfunction of the RAS, in turn leading to worsening systemic inflammation and vascular permeability, eventually leading to ARDS, multi organ failure and mortality [23] , [24] , [25] . The hypersecretion of cytokines may also have direct cardiovascular effects including the reduction of coronary blood flow, the destabilization of atherosclerotic plaques and the formation of microthrombi [26] .…”

Section: Evaluation Of the Hypothesismentioning

confidence: 99%

COVID-19 and the renin-angiotensin system (RAS): A spark that sets the forest alight?

2020

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The coronavirus disease 2019 (COVID-19) pandemic has increased exponentially in numbers with more than 20 million people infected around the globe. It is clear that COVID-19 is not a simple viral pneumonia, but presents with unusual pathophysiological effects. Of special interest is that SARS-CoV-2 utilises the angiotensin-converting enzyme-2 (ACE2) for cell entry and therefore has a direct effect on the renin angiotensin system (RAS). The RAS is primarily responsible for blood pressure control via the classic pathway. Recently numerous other pathological processes have been described due to stimulation of this classic pathway. There is also a protective RAS pathway medicated by ACE2 which may be suppressed in COVID-19. This leads to overstimulation of the classic pathway with adverse cardiovascular and respiratory effects, hypercoagulation, endothelial dysfunction, inflammation and insulin resistance. We hypothesize that overreaction of the renin-angiotensin-aldosterone may account for the myriad of unusual biochemical and clinical abnormalities noted in patients infected with SARS-CoV-2.

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Section: Evaluation Of the Hypothesismentioning

confidence: 99%

COVID-19 and the renin-angiotensin system (RAS): A spark that sets the forest alight?

2020

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Mathematical Model for the Investigation of Hypoxic States in the Heart Muscle at Viral Damage

Aralova¹

2021

Biotechnol. acta

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The main complications of organism damaged by SARS-CoV-2 virus are various cardiovascular system lesions. As a result, the secondary tissue hypoxia is developed and it is relevant to search the means for hypoxic state alleviation. Mathematical modeling of this process, followed by the imitation of hypoxic states development, and subsequent correction of hypoxia at this model may be one of the directions for investigations. Aim. The purpose of this study was to construct mathematical models of functional respiratory and blood circulatory systems to simulate the partial occlusion of blood vessels during viral infection lesions and pharmacological correction of resulting hypoxic state. Methods. Methods of mathematical modeling and dynamic programming were used. Transport and mass exchange of respiratory gases in organism, partial occlusion of blood vessels and influence of antihypoxant were described by the systems of ordinary nonlinear differential equations. Results. Mathematical model of functional respiratory system was developed to simulate pharmacological correction of hypoxic states caused by the complications in courses of viral infection lesions. The model was based on the theory of functional systems by P. K. Anokhin and the assumption about the main function of respiratory system. The interactions and interrelations of individual functional systems in organism were assumed. Constituent parts of our model were the models of transport and mass exchange of respiratory gases in organism, selforganization of respiratory and blood circulatory systems, partial occlusion of blood vessels and the transport of pharmacological substance. Conclusions. The series of computational experiments for averaged person organism demonstrated the possibility of tissue hypoxia compensation using pharmacological substance with vasodilating effect, and in the case of individual data array, it may be useful for the development of strategy and tactics for individual patient medical treatment.

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Features of the Course of Arterial Hypertension in the Era of the COVID-19 Pandemic: Common Pathogenetic Links Between Hypertension and SARS-CoV-2

Berns,

Leontyeva,

Tavlueva

et al. 2024

Kardiologiia

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Possible effects of coronavurus infection (COVID-19) on the cardiovascular system

Cited by 6 publications

References 33 publications

COVID-19 and the renin-angiotensin system (RAS): A spark that sets the forest alight?

COVID-19 and the renin-angiotensin system (RAS): A spark that sets the forest alight?

Mathematical Model for the Investigation of Hypoxic States in the Heart Muscle at Viral Damage

Features of the Course of Arterial Hypertension in the Era of the COVID-19 Pandemic: Common Pathogenetic Links Between Hypertension and SARS-CoV-2

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