Possible effect of the <i>APOE</i> ε4 allele on the hippocampal volume and asymmetry in schizophrenia

Hata, Takanori; Nanko, Shinichiro; Fukuda, Ryouichi; Kaminaga, Tatsuro

doi:10.1002/ajmg.10556

Cited by 12 publications

(5 citation statements)

References 11 publications

(12 reference statements)

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“…They discovered that treatment with apoE3 increased both neurite extension and combined length in a dose-dependent fashion, whereas the functions of apoE4 were the opposite, i.e., a decrease in both effects (Nathan et al 2002). Hata et al observed a trend toward decreased hippocampal volume and asymmetry in subjects with schizophrenia and e4 allele (Hata et al 2002). In conclusion, APOE polymorphism is not associated with an elevated risk of schizophrenia or with treatment response with conventional antipsychotics.…”

Section: Discussionmentioning

confidence: 96%

Apolipoprotein E polymorphism is associated with age of onset in schizophrenia

et al. 2004

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The aims of the study were to investigate the relationship between Apolipoprotein E (APOE) polymorphism, risk of schizophrenia, treatment response to conventional anti-psychotics, and age of onset in schizophrenia. The sample comprised 94 Finnish patients with a DSM-IV diagnosis of schizophrenia. Forty-three of the patients were good responders to conventional anti-psychotics and 51 were classified as non-responders. The control group consisted of 98 healthy blood donors. The APOE allele frequencies (e2, e3, and e4) were 4.8, 72.3, and 22.9% in patients and 7.1, 75.0, and 17.9 in controls. None of the differences between groups were statistically significant. No association between treatment response and APOE genotype was found. Patients with APOE e4/e4 genotype had a markedly lower age of onset compared with rest of the sample (p=0.0015), which remained significant when controlling for gender (p=0.02). There was an increasing linear trend between the number of e3 alleles (0, 1, or 2) and age of onset in schizophrenia (p=0.08). An inverse trend was found between the number of e4 alleles and age of onset (p=0.07). No relationship between APOE polymorphism and risk for schizophrenia was found. APOE e4/e4 genotype may be associated with early onset schizophrenia. APOE e3 allele may function protectively in later onset in this disease.

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Section: Discussionmentioning

confidence: 96%

Apolipoprotein E polymorphism is associated with age of onset in schizophrenia

et al. 2004

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“…The APOE e4 allele is a major risk allele for late-onset Alzheimer's disease (Mahaney et al, 1993). The study by Hata et al (2002) shows similar findings to studies carried out in patients with Alzheimer's disease (Soininen and Riekkinen, 1996;Tohgi et al, 1997) in that there is a decrease in hippocampal volume of the e4 allele carriers compared to noncarriers. The IL-RII gene has been studied twice until now, one showing an association between a high activity allele in the interleukin-1b (IL-1b) gene and orbitofrontotemporal volume reductions of gray and white matter in schizophrenia subjects but not in controls (Meisenzahl et al, 2001) and the other study showing variability at the IL-1RN gene contributing to the ventricular volumetric variation in patients with schizophrenia.…”

Section: B Genes For Brain Structures In Patients With Schizophreniasupporting

confidence: 80%

Studies of the affective and developmental domains of psychopathology in psychosis

Kaymaz¹

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“…116 Patients (N = 21) with e4 allele (n = 7) of the ApoE polymorphism rs429358 showed a trend towards reduced ratio of right hippocampus to hemisphere volumes (T = 1.9, df = 19, P < 0.10) compared to e2 and e3 allele carriers (n = 14). 117 However, no such association between the e4 allele (n = 14) and hippocampal (t = 0.23, df = 33, P < 0.82) volumes (t = 0.27, df = 33, P < 0.79) was found in patients with childhood-onset schizophrenia (COS) (N = 40). 118 (xvii).…”

Section: (Ix) Neurotrophin-3 (Ntf-3/nt-3)mentioning

confidence: 97%