Possible Dual Effect of Cd14 Molecule on Atopy

Kusunoki, Takashi; Nakahata, Tatsutoshi; Miyanomae, Takeshi; Inoue, Yasuhiro

doi:10.1164/ajrccm.165.4.correspondenceib

Cited by 11 publications

(12 citation statements)

References 8 publications

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“…This lack of association was also reported by other authors (10,15). The mechanism through which CD14 might act in atopy is not known.…”

Section: Discussionsupporting

confidence: 67%

“…In contrast, other studies reported higher serum sCD14 levels in allergic alveolitis (12), atopic dermatitis (13), and asthma (14,15,20). Moreover, several authors found no differences in sCD14 concentrations between atopics and non-atopics (21,22).…”

Section: Discussionmentioning

confidence: 77%

“…These contradicting effects of sCD14 can be explained by the fact that higher sCD14 levels in asthmatic patients are secondary to allergic inflammation. Thus, Kusunoki et al (15) have proposed that CD14 can have a dual effect on atopy; it inhibits IgE production before allergic inflammation and stimulates IgE after its onset.…”

mentioning

confidence: 99%

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Soluble CD14 and total IgE in the serum of atopic and nonatopic adolescents in relation to environmental factors: a pilot study / Topivi receptor CD14 i ukupni IgE u serumu mladih atopičara odrasle dobi u ovisnosti o čimbenicima iz okoliša: pilot istraživanje

Prester

Varnai

Macan

2015

Archives of Industrial Hygiene and Toxicology

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The CD14 receptor is expressed on the surfaces of monocytes, macrophages, and, to a lesser extent, of activated granulocytes and B lymphocytes (mCD14). It also exists in soluble form in the serum (sCD14), in which it binds microbial compounds and indoor allergens. The objectives of this study were to see whether serum sCD14 concentrations could be used as a marker of atopic disorders and to estimate the effects of environmental factors (tobacco smoke exposure, childhood residence in urban or rural areas, and having a pet) on sCD14 and IgE values. Mass fraction of sCD14 and total IgE were determined in the sera of atopic (N=53) and non-atopic (N=35) participants using the standard enzyme-linked immunosorbent assay. Exposure to pets and environmental tobacco smoke was estimated based on the International Study of Asthma and Allergies in Childhood questionnaire (ISAAC). Median sCD14 concentration was significantly lower in atopic than in non-atopic girls (3.49 vs. 3.83 μg mL -1 ; p<0.010). The number of smokers at home positively correlated with the sCD14 level in atopics, and urban atopics had significantly lower sCD14 levels than rural atopics (3.47 vs. 3.92 μg mL -1 , p=0.028). Median total IgE concentration was significantly lower in atopic pet owners than in atopics with no pets (161 vs. 252 kIU L -1 ; p=0.021). In conclusion, while sex and environmental factors might be involved in sCD14 expression, particularly in atopics, we found no correlation between sCD14 and total IgE concentrations. The usefulness of sCD14 as a marker of atopic disorders should be investigated further, particularly in relation to the severity of allergic disorders.KEY WORDS: allergy; atopy; environmental tobacco smoke; immunoglobulin E; sCD14; pets Prester Lj, et al. Soluble CD14 and total IgE in the serum of atopic and non-atopic adolescents in relation to environmental factors: a pilot study Arh Hig Rada Toksikol 2015;66:41-49

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“…This lack of association was also reported by other authors (10,15). The mechanism through which CD14 might act in atopy is not known.…”

Section: Discussionsupporting

confidence: 67%

Section: Discussionmentioning

confidence: 77%

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Soluble CD14 and total IgE in the serum of atopic and nonatopic adolescents in relation to environmental factors: a pilot study / Topivi receptor CD14 i ukupni IgE u serumu mladih atopičara odrasle dobi u ovisnosti o čimbenicima iz okoliša: pilot istraživanje

Prester

Varnai

Macan

2015

Archives of Industrial Hygiene and Toxicology

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“…We speculate that disease activity (at the moment of breast milk sampling) in atopic mothers may be reflected in higher sCD14 levels. Higher levels of serum sCD14 are seen in subjects with disease activity for instance after exacerbation of asthma in children [25,26]. However, we did not assess the asthmatic status or the presence of rhinoconjuctivitis at the moment of breast milk sampling.…”

Section: Discussionmentioning

confidence: 99%

Cytokines and soluble CD14 in breast milk in relation with atopic manifestations in mother and infant (KOALA Study)

Snijders

Damoiseaux²,

Penders

et al. 2006

Clin Experimental Allergy

113

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SummaryBackground Conflicting evidence exists concerning the protective role of breastfeeding in allergy and atopic disease aetiology. Breast milk contains biologically active molecules influencing the innate immune system of newborns. Objective We aim to assess whether cytokines (TGF-b1, IL-10 and IL-12) and soluble CD14 (sCD14) in breast milk are influenced by maternal atopic constitution and modify the development of atopic manifestations in infants. Methods Milk samples were collected at 1 month post-partum of 315 lactating mothers participating in the ongoing KOALA Birth Cohort Study. The cytokines and sCD14 were analysed by ELISA in the aqueous fraction. We compared the concentrations of cytokines and sCD14 in breast milk between mothers with and without an allergic history and also with and without allergic sensitization (specific IgE). Associations of cytokines and sCD14 with the development of eczema, wheezing in the first 2 years of life and allergic sensitization of infants at the age of 2 years were analysed by multivariate logistic regression analyses to correct for confounders. Results We found higher sCD14 levels in mothers with a positive vs. negative allergic history (7.6 vs. 7.0 mg/mL; P = 0.04) and in mothers who were sensitized vs. non-sensitized (7.8 vs. 7.1 mg/mL; P = 0.03). None of the studied immune factors were associated with infant's atopic outcomes. IL-10 was not detected above the detection limit of 0.2 pg/mL. Conclusion Taking together the results of the present and previous studies, we conclude that there is no convincing evidence for a relation between TGF-b1, sCD14, IL-10 or IL-12 in breast milk and atopic manifestations in infants.

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“…CD14 functions as a receptor for LPS on several types of cells, thereby inducing mediator and cytokine release (Gao et al 1999). Complexes of CD14 and bacterial LPS may increase Th1-favoured T cell differentiation and activate greater expression of sCD14, which may result in a reduction in the serum IgE levels (Kusunoki et al 2002). In addition, bronchoalveolar lavage studies suggest that CD14-mediated cell activation could play a role in the inflammatory response after allergen challenge (Dubin et al 1996).…”

Section: Discussionmentioning

confidence: 99%

Polymorphisms of the CD14 gene and atopic phenotypes in Czech patients with IgE-mediated allergy

et al. 2006

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Possible Dual Effect of Cd14 Molecule on Atopy

Cited by 11 publications

References 8 publications

Soluble CD14 and total IgE in the serum of atopic and nonatopic adolescents in relation to environmental factors: a pilot study / Topivi receptor CD14 i ukupni IgE u serumu mladih atopičara odrasle dobi u ovisnosti o čimbenicima iz okoliša: pilot istraživanje

Soluble CD14 and total IgE in the serum of atopic and nonatopic adolescents in relation to environmental factors: a pilot study / Topivi receptor CD14 i ukupni IgE u serumu mladih atopičara odrasle dobi u ovisnosti o čimbenicima iz okoliša: pilot istraživanje

Cytokines and soluble CD14 in breast milk in relation with atopic manifestations in mother and infant (KOALA Study)

Polymorphisms of the CD14 gene and atopic phenotypes in Czech patients with IgE-mediated allergy

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