Possible contribution of green tea drinking habits to the prevention of stroke.

Sato, Yoshikazu; Nakatsuka, Haruo; Watanabe, Takao; Hisamichi, Shigeru; Shimizu, Hiroyuki; Fujisaku, Susumu; Ichinowatari, Yoshimi; Ida, Yasuo; Suda, Seiki; Katö, Kunio; Ikeda, Masayuki

doi:10.1620/tjem.157.337

Cited by 89 publications

(42 citation statements)

References 14 publications

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“…14 Approximately 50% of Japanese aged over 40 years usually drink ≥4 cups/day. 19,20 In the present study, 47% of the patients drank >3 cups/day, which is comparable with the general Japanese population. The lack of an association between green tea consumption and CAD in Hirano's report may be due to their subjects' low average intake of green tea.…”

Section: Discussionsupporting

confidence: 83%

Effects of Green Tea Intake on the Development of Coronary Artery Disease

Sano

Inami

Seimiya

et al. 2004

Circ J

103

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Section: Discussionsupporting

confidence: 83%

Effects of Green Tea Intake on the Development of Coronary Artery Disease

Sano

Inami

Seimiya

et al. 2004

Circ J

103

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“…There are many reports in the literature of beneficial effects of green tea consumption, some of which relate to pathologies in which turnover of extracellular matrix proteins is a major component, such as stroke and cerebral haemorrhage [62] and cancer [63,64]. The anticancer effects of polyphenolic compounds from green tea have been attributed, at least in part, to their direct inhibition of matrixins such as the gelatinases [4][5][6].…”

Section: Discussionmentioning

confidence: 99%

Selective inhibition of ADAMTS‐1, ‐4 and ‐5 by catechin gallate esters

Vankemmelbeke

Jones

Fowles

et al. 2003

European Journal of Biochemistry

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Three mammalian ADAMTS enzymes, ADAMTS-1, -4 and -5, are known to cleave aggrecan at certain glutamyl bonds and are considered to be largely responsible for cartilage aggrecan catabolism observed during the development of arthritis. We have previously reported that certain catechins, polyphenolic compounds found in highest concentration in green tea (Camellia sinensis), are capable of inhibiting cartilage aggrecan breakdown in an in vitro model of cartilage degradation. We have now cloned and expressed recombinant human ADAMTS-1, -4 and -5 and report here that the catechin gallate esters found in green tea potently inhibit the aggrecan-degrading activity of these enzymes, with submicromolar IC 50 values. Moreover, the concentration needed for total inhibition of these members of the ADAMTS group is approximately two orders of magnitude lower than that which is needed to partially inhibit collagenase or ADAM-10 activity. Catechin gallate esters therefore provide selective inhibition of certain members of the ADAMTS group of enzymes and could constitute an important nutritional aid in the prevention of arthritis as well as being part of an effective therapy in the treatment of joint disease and other pathologies involving the action of these enzymes.Keywords: ADAMTS; enzyme inhibition; catechin; gallate; aggrecanase.Green tea, made from the leaves of Camellia sinensis, contains catechins, a group of polyphenolic compounds with antioxidant properties that have been at the centre of investigations into the potential medical benefits of consuming green tea. The most abundant catechin in green tea is (-)-epigallocatechin gallate (EGCG) with others such as (-)-epicatechin (EC), (-)-epigallocatechin (EGC) and (-)-epicatechin gallate (ECG) also present. Anti-inflammatory and anti-mitotic properties have been attributed to these compounds [1-3] and they have also been reported to inhibit certain matrixins such as the gelatinases [4][5][6]. The beneficial effects on a range of clinical conditions including cancer growth and metastasis [7][8][9][10][11], cardiovascular and liver diseases [12] may therefore be due to one or a combination of these properties.Aggrecan, a large aggregating proteoglycan, is together with type II collagen the major constituent of articular cartilage. Degradation of cartilage aggrecan has mainly been attributed to the action of glutamyl endopeptidases, termed ÔaggrecanasesÕ. Aggrecan degradation products resulting from aggrecanase action have been found in in vitro cultures of cartilage treated with proinflammatory cytokines as well as in synovial fluid of arthritis patients [13][14][15][16]. To date three mammalian ÔaggrecanasesÕ have been identified: a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)-1, -4 and -5 [17][18][19]. The ADAMTS enzymes belong to a subgroup of metallopeptidases in Family M12 of Clan MA in the Merops database [20] and are related to the ADAMs and matrixins [21]. So far, at least 18 mammalian ADAMTS enzymes have been identified, most of which remain t...

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“…Although the majority of studies have been conducted in populations drinking black tea, positive findings are emerging for green tea. For example, the two existing studies on green tea and stroke have both shown protective effects (104,105) . In addition, tea consumption has been inversely associated with precursors of CVD including atherosclerosis (101,106) and hypertension (107)(108)(109) .…”

Section: Cancersmentioning

confidence: 99%

Tea or coffee? A case study on evidence for dietary advice

Binns

Lee

Fraser

2008

Public Health Nutr.

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The present paper explores the level of evidence required to justify giving dietary advice to the public. There are important practical differences between the development of public health nutrition guidelines and guidelines for clinical practice. While the gold standard for evidence for clinical practice guidelines is a meta-analysis of a number of randomised controlled trials, this is often unrealistic and sometimes unethical for the evaluation of public health nutrition interventions. Hence, epidemiological studies make up the bulk of evidence for nutrition guidelines. Tea and coffee are an interesting case study in relation to this issue. They are two of the most commonly consumed beverages worldwide, yet there is little dietary advice on their use. The evidence for a relationship between coffee or tea consumption and several diseases is discussed. The available studies, predominantly epidemiological, together with animal and in vitro studies, indicate that coffee and tea are both safe beverages. However, tea is the healthier option because it has a possible role in the prevention of several cancers and CVD. While the evidence for such relationships is not strong, the public will continue to drink both tea and coffee, and will continue to ask nutritionists to make recommendations. It is therefore argued that advice should be given on the best available data, as waiting for complete data to become available could have severe consequences for public health.

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Possible contribution of green tea drinking habits to the prevention of stroke.

Cited by 89 publications

References 14 publications

Effects of Green Tea Intake on the Development of Coronary Artery Disease

Effects of Green Tea Intake on the Development of Coronary Artery Disease

Selective inhibition of ADAMTS‐1, ‐4 and ‐5 by catechin gallate esters

Tea or coffee? A case study on evidence for dietary advice

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