Possible connection between diet and microRNA in cancer scenario

Otsuka, Kurataka; Ochiya, Takahiro

doi:10.1016/j.semcancer.2020.11.014

Cited by 12 publications

(8 citation statements)

References 266 publications

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“…In this way, quercetin may be an effective bioagent in preventing the onset and progression of cancer (D. H. Kim et al, 2019). In different cancers (colon, breast, oral, and pancreatic), the regulation of miRNAs (in addition to the previously mentioned, miR‐16, miR‐34a, miR‐22, miR‐5096, miR‐103, miR‐1202, miR‐125b, miR‐338‐3p, miR‐125b‐2‐3p, miR‐320b, miR‐142‐3p, miR‐217, miR‐145, miR‐200b, and miR‐200a) has been shown to inhibit cell proliferation (Otsuka & Ochiya, 2021). Quercetin downregulated miR‐27a and miR‐155; upregulated miR‐146a and miR‐let‐7 in breast cancer (D. H. Kim et al, 2019).…”

Section: Immuno‐foods and Immuno‐phytonutrientsmentioning

confidence: 92%

Recent insights into the nutritional immunomodulation of cancer‐related microRNAs

Şahin

Yılmaz

Yeşilyurt

et al. 2023

Phytotherapy Research

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Cancer is the most common cause of death worldwide, following cardiovascular diseases. Cancer is a multifactorial disease and many reasons such as physical, chemical, biological, and lifestyle‐related factors. Nutrition, which is one of the various factors that play a role in the prevention, development, and treatment of many types of cancer, affects the immune system, which is characterized by disproportionate pro‐inflammatory signaling in cancer. Studies investigating the molecular mechanisms of this effect have shown that foods rich in bioactive compounds, such as green tea, olive oil, turmeric, and soybean play a significant role in positively changing the expression of miRNAs involved in the regulation of genes associated with oncogenic/tumor‐suppressing pathways. In addition to these foods, some diet models may change the expression of specific cancer‐related miRNAs in different ways. While Mediterranean diet has been associated with anticancer effects, a high‐fat diet, and a methyl‐restricted diet are considered to have negative effects. This review aims to discuss the effects of specific foods called “immune foods,” diet models, and bioactive components on cancer by changing the expression of miRNAs in the prevention and treatment of cancer.

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Section: Immuno‐foods and Immuno‐phytonutrientsmentioning

confidence: 92%

Recent insights into the nutritional immunomodulation of cancer‐related microRNAs

Şahin

Yılmaz

Yeşilyurt

et al. 2023

Phytotherapy Research

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“…Recently, there has been a growing interest in the relationship between gut microbiota composition and obesity. Adipose tissues play a crucial role in regulating energy balance and lipid metabolism through the secretion of various peptide hormones, such as adiponectin, leptin, resistin, and tumor necrosis factor-α (TNF-α)[ 70 ]. Many disorders, including but not limited to type 2 diabetes, non-alcoholic steatohepatitis (NASH), dyslipidemia, and various other illnesses, are caused by obesity.…”

Section: Obesitymentioning

confidence: 99%

Diet-Induced Gut Dysbiosis and Leaky Gut Syndrome

Chae,

Lee,

Kim

et al. 2024

J. Microbiol. Biotechnol.

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Chronic gut inflammation promotes the development of metabolic diseases such as obesity. There is growing evidence which suggests that dysbiosis in gut microbiota and metabolites disrupt the integrity of the intestinal barrier and significantly impact the level of inflammation in various tissues, including the liver and adipose tissues. Moreover, dietary sources are connected to the development of leaky gut syndrome through their interaction with the gut microbiota. This review examines the effects of these factors on intestinal microorganisms and the communication pathways between the gut-liver and gut-brain axis. The consumption of diets rich in fats and carbohydrates has been found to weaken the adherence of tight junction proteins in the gastrointestinal tract. Consequently, this allows endotoxins, such as lipopolysaccharides produced by detrimental bacteria, to permeate through portal veins, leading to metabolic endotoxemia and alterations in the gut microbiome composition with reduced production of metabolites, such as short-chain fatty acids. However, the precise correlation between gut microbiota and alternative sweeteners remains uncertain, necessitating further investigation. This study highlights the significance of exploring the impact of diet on gut microbiota and the underlying mechanisms in the gut-liver and gut-brain axis. Nevertheless, limited research on the gut-liver axis poses challenges in comprehending the intricate connections between diet and the gut-brain axis. This underscores the need for comprehensive studies to elucidate the intricate gut-brain mechanisms underlying intestinal health and microbiota.

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“…MicroRNAs (miRNA, miR) are short, 17-nucleotide- to 25-nucleotide-long, non-coding RNAs [ 22 , 23 , 24 ]. They are regulators of gene expression at the post-transcriptional level [ 25 , 26 ].…”

Section: Micrornas As a Potential Source Of Biomarkers In Parathyroid...mentioning

confidence: 99%

“…Circulating miRNAs are remarkably stable in the blood and seem more practical in diagnostic use than tissue miRNA expression. They can serve as an informative biomarker for detecting various cancers and other diseases [ 21 , 23 , 32 , 33 ]. Circulating miRNAs comprise free and vesicular miRNAs [ 34 ].…”

Section: Micrornas As a Potential Source Of Biomarkers In Parathyroid...mentioning

confidence: 99%

MicroRNA Profile Alterations in Parathyroid Carcinoma: Latest Updates and Perspectives

Wielogórska

Podgórska

Niemira

et al. 2022

Cancers

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Parathyroid tumors are a genetically heterogenous group with a significant variability in clinical features. Due to a lack of specific signs and symptoms and uncertain histopathological criteria, parathyroid carcinomas (PCs) are challenging to diagnose, both before and after surgery. There is a great interest in searching for accurate molecular biomarkers for early detection, disease monitoring, and clinical management. Due to improvements in molecular pathology, the latest studies have reported that PC tumorigenesis is strongly linked to the epigenetic regulation of gene expression. MicroRNA (miRNA) profiling may serve as a helpful adjunct in distinguishing parathyroid adenoma (PAd) from PC and provide further insight into regulatory pathways involved in PTH release and parathyroid tumorigenesis. So far, only a few studies have attempted to show the miRNA signature for PC, and very few overlaps could be found between these relatively similar studies. A global miRNA downregulation was detected in PC compared with normal glands among differentially expressed miRNAs. This review summarizes changes in miRNA expression in PC and discusses the future research directions in this area.

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Possible connection between diet and microRNA in cancer scenario

Cited by 12 publications

References 266 publications

Recent insights into the nutritional immunomodulation of cancer‐related microRNAs

Recent insights into the nutritional immunomodulation of cancer‐related microRNAs

Diet-Induced Gut Dysbiosis and Leaky Gut Syndrome

MicroRNA Profile Alterations in Parathyroid Carcinoma: Latest Updates and Perspectives

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