Possible cholinergic neurotransmission in the cristae ampullares of the chick inner ear

Meza, Graciela; López, Iván; Ruíz, Mariano

doi:10.1016/0304-3940(84)90142-3

Cited by 12 publications

(1 citation statement)

References 24 publications

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“…In homogenates of the isolated frog vestibule the activity of ChAT was reduced by up to 88% six weeks following vestibular nerve transection, while the activity of glutamate decarboxylase was unchanged in the same homogenates (L6pez and Meza, 1988). Similar findings were observed in chick, rat and guinea pig (Meza et al, 1984;L6pez andMeza, 1988 &.…”

Section: Introductionsupporting

confidence: 78%

Choline acetyltransferase immunoreactivity in the human vestibular end‐organs

Ishiyama¹

1994

Cell Biology International

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Acetylcholine (ACh) is believed to play a major role in the efferent vestibular system in several animal models, however no information regarding the role of ACh in the human efferent vestibular system has been published. Post-embedding immunohistochemistry in a hydrophilic resin was used to investigate the choline acetyltransferase immunoreactivity (ChATi) and acetylcholinesterase (AChE) histochemistry in human vestibular end-organs. ChATi and AChE activity was found in numerous bouton-type terminals at the basal area of the vestibular hair cells. These terminals were found to contact type II vestibular hair cells and the afferent chalices surrounding type I hair cells. This study provides the first evidence that the human efferent vestibular axons and terminals are cholinergic.

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Section: Introductionsupporting

confidence: 78%

Choline acetyltransferase immunoreactivity in the human vestibular end‐organs

Ishiyama¹

1994

Cell Biology International

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The demonstration of choline acetyltransferase activity in cultured vestibular ganglion cells from the fetal rat

Yamashita

Sekitani

1990

Eur Arch Otorhinolaryngol

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Some properties of frog vestibular choline acetyltransferase and acetylcholinesterase

López

Meza

1989

Neurochem Res

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The amount and some properties of choline acetyltransferase (ChAT) and of acetylcholinesterase (AchE) were investigated in the frog vestibule. Enzyme activities were found to be of the same order of magnitude as in frog nervous tissue and various properties of vestibular ChAT (dependence on pH, chloride and Triton X-100 activation, phosphate sensitivity) and AchE (inhibition by eserine but not by Tetraisopropylpyrophosphoramide) were also similar as those of the homologous central nervous system enzymes. Although the precise localization of ChAT and AchE is not yet certain the efferent neurotransmitter in the vertebrate vestibular sensory periphery is believed to be acetylcholine and thus the enzymes responsible for its synthesis and degradation may participate in regulating inner ear function.

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Possible cholinergic neurotransmission in the cristae ampullares of the chick inner ear

Cited by 12 publications

References 24 publications

Choline acetyltransferase immunoreactivity in the human vestibular end‐organs

Choline acetyltransferase immunoreactivity in the human vestibular end‐organs

The demonstration of choline acetyltransferase activity in cultured vestibular ganglion cells from the fetal rat

Some properties of frog vestibular choline acetyltransferase and acetylcholinesterase

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