Possible beneficial impact of surgical deroofing procedure to cover the disadvantage of adalimumab treatment for hidradenitis suppurativa

Saito‐Sasaki, Natsuko; Sawada, Yu; Sato, Sayaka; Sugino, Hitomi; Minokawa, Yoko; Nanamori, Hikaru; Yamamoto, Kayo; Okada, Etsuko; Nakamura, Motonobu

doi:10.1111/1346-8138.16146

Cited by 3 publications

(6 citation statements)

References 5 publications

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“…Contrary to Saito-Sasaki et al (2022) [ 22 ], Brown et al (1986) documented four instances of refractory HS, effectively resolved with deroofing. Wide excision was not feasible in these cases since the HS was pervasive.…”

Section: Reviewmentioning

confidence: 89%

“…The clinical evidence underscores the effectiveness of surgical deroofing and carbon dioxide laser treatment as viable approaches for managing symptomatic HS. Although their efficacy appears comparable, an analysis of 18 studies involving 1,120 patients indicates that surgical deroofing carries a higher recurrence rate compared to the carbon dioxide laser technique [17][18][19][20][21][22][24][25][26][27][28][29][30][31][32][33][34][35]. The visual representation in Figure 2 delineates the recurrence rates of HS lesions post-surgical deroofing and carbon dioxide laser procedures.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, a second deroofing was performed, and the patient received two weeks of cephalosporin before initiating adalimumab for four months. The patient remained recurrence-free for one year after treatment [ 22 ].…”

Section: Reviewmentioning

confidence: 99%

“…These findings suggest that surgical deroofing with adalimumab as a postoperative prophylactic may be an effective treatment approach for refractory HS. Future research studies with larger samples must confirm these results and identify the optimal treatment duration [ 22 ].…”

Section: Reviewmentioning

confidence: 99%

“…Deroofing was effective in each case only after subsequent administration of antibiotics and adalimumab. Future research can build on these findings and assess the efficacy of adalimumab with and without deroofing in treating patients with recurrent HS [ 22 ].…”

Section: Reviewmentioning

confidence: 99%

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Effectiveness of Surgical Deroofing and Carbon Dioxide Laser in Moderate-to-Severe Hidradenitis Suppurativa Patients

Clark,

Soti

2024

Cureus

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Hidradenitis suppurativa (HS) is a chronic, inflammatory skin condition that causes pain and discomfort in various body regions. This review explores the comparative effectiveness of two surgical techniques, namely, surgical deroofing and carbon dioxide laser therapy, in managing symptomatic HS, particularly in patients with Hurley stage I-III disease. We conducted a systematic literature search on PubMed and ClinicalTrials.gov . The clinical evidence suggests that surgical deroofing and carbon dioxide laser treatment are effective strategies for managing symptomatic HS. However, a comprehensive analysis of 1,120 patients indicates a higher recurrence rate with surgical deroofing. Further investigation into short-term and long-term follow-up data revealed comparable recurrence-free rates within 12 months post-procedure. Beyond 12 months, carbon dioxide laser treatment exhibited slightly higher recurrence-free rates, which necessitate more extensive studies for validation due to the limited sample size. In addition, surgical deroofing demonstrated quicker healing times, while carbon dioxide laser therapy showcased varying timelines, with primary closure after laser excision presenting a two-week healing time. Both procedures reported high patient satisfaction, emphasizing the need for personalized treatment decisions. Therefore, further research is essential to evaluate the efficacy of each treatment modality considering individual patient profiles and disease severity. It will benefit individuals affected by HS, leading to better health outcomes.

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Section: Reviewmentioning

confidence: 89%