Possible association of temporomandibular joint pain and dysfunction with a polymorphism in the serotonin transporter gene

Herken, Hasan; Erdal, Mehmet Emin; Mutlu, Necip; Barlas, İbrahim Ömer; Çataloluk, Osman; Öz, Fatih; Güray, Enis

doi:10.1067/mod.2001.115307

Cited by 57 publications

(39 citation statements)

References 24 publications

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“…The short (14-repeat) allele of 5-HTTLPR was shown to have lower transcriptional activity leading to lower neuronal serotonin reuptake [23] and is associated with a better analgesic effect of remifentanil in healthy volunteers undergoing heat-pain stimulation [24]. Another polymorphism in the second intron of the serotonin transporter gene (STin2), containing a 16-to-17 base pair sequence with, most commonly, 10 or 12 repeats, was found to be associated with joint pain severity [25].…”

Section: Neurotransmissionmentioning

confidence: 99%

Biological pathways and genetic variables involved in pain

et al. 2010

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Candidate gene association studies have been used to provide evidence for the genetic modulation of pain perception and response to analgesics. However, the nature and range of genetic modulation of pain is not well addressed due to the limited number of patients and the limited number of genes and genetic variants investigated in studies to date. Moreover, personalized analgesic treatments will require a more complete understanding of the effects of genetic variants and gene-gene interactions in response to analgesics.

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Section: Neurotransmissionmentioning

confidence: 99%

Biological pathways and genetic variables involved in pain

et al. 2010

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“…The polymorphism of the VNTR region in the 5-HTT was shown to be associated with myofacial pain syndrome and migraine as well [49,31]. To our knowledge, the VNTR polymorphism has not been investigated in ADHD to date.…”

Section: Discussionmentioning

confidence: 99%

Significance of Serotonin Transporter Gene 5-HTTLPR and Variable Number of Tandem Repeat Polymorphism in Attention Deficit Hyperactivity Disorder

Zoroğlu

Erdal²,

Alaşehirli³

et al. 2002

Neuropsychobiology

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The purpose of this study was to evaluate the relationship between attention deficit hyperactivity disorder (ADHD) and polymorphism of the two regions of the 5-HTT gene [variable number of tandem repeats (VNTR) and 5-HTTLRR] in a sample of Turkish children. Using the PCR technique, these polymorphisms were assessed in 71 patients with ADHD and 128 healthy controls. The 5-HTTLPR S/S genotype was significantly lower in the patients than in the controls (p = 0.018). Homozygous and heterozygous L variant predominated in the ADHD group. But the VNTR STin2.12/12 genotype was significantly less found in the patients than in the controls (p = 0.001). There was no significant difference between the frequency of the short (S), long, 10, and 12 alleles of both groups. The lack of an S/S variant of 5-HTTLPR polymorphism of the STin2.12/12 variant of VNTR polymorphism appears to be associated with an increased risk of ADHD.

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“…81 Common polymorphisms in the promoter of the serotonin transporter gene are associated with depression, stress-related suicidality, 15 anxiety, 40 somatization, and TMD risk. 48 It is likely that there are several genes that exhibit such pleiotropic effects, which interact to contribute to specific quantitative phenotypic traits or factors that combine to form specific clusters (Supplementary Table 1). …”

Section: Etiology and Mechanismsmentioning

confidence: 99%

Overlapping Chronic Pain Conditions: Implications for Diagnosis and Classification

Maixner

Fillingim

Williams

et al. 2016

The Journal of Pain

370

335

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There is increasing recognition that many if not most common chronic pain conditions are heterogeneous with a high degree of overlap or coprevalence of other common pain conditions along with influences from biopsychosocial factors. At present, very little attention is given to the high degree of overlap of many common pain conditions when recruiting for clinical trials. As such, many if not most patients enrolled into clinical studies are not representative of most chronic pain patients. The failure to account for the heterogeneous and overlapping nature of most common pain conditions may result in treatment responses of small effect size when these treatments are administered to patients with chronic overlapping pain conditions (COPCs) represented in the general population. In this brief review we describe the concept of COPCs and the putative mechanisms underlying COPCs. Finally, we present a series of recommendations that will advance our understanding of COPCs. Perspective: This brief review describes the concept of COPCs. A mechanism-based heuristic model is presented and current knowledge and evidence for COPCs are presented. Finally, a set of recommendations is provided to advance our understanding of COPCs.

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Possible association of temporomandibular joint pain and dysfunction with a polymorphism in the serotonin transporter gene

Cited by 57 publications

References 24 publications

Biological pathways and genetic variables involved in pain

Biological pathways and genetic variables involved in pain

Significance of Serotonin Transporter Gene 5-HTTLPR and Variable Number of Tandem Repeat Polymorphism in Attention Deficit Hyperactivity Disorder

Overlapping Chronic Pain Conditions: Implications for Diagnosis and Classification

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