“…For the past two decades, many genetic association studies have demonstrated strong association of genetic variants on biologically plausible genes responsible for arachidonic acid metabolism, including LTC4S [ 5 ] ALOX5 [ 6 ], CYSLT1R [ 7 ], CYSLT2R [ 8 ], PTGER [ 9 – 11 ], TBXAS1 [ 12 ], and TBXA2R [ 13 ], with the development of AERD. Other studies also identified that genes in the immune response and inflammatory pathways were associated with the adverse reaction to aspirin,, including HLA-DPB1 [ 14 ], IL-4 [ 15 ], T-Box [ 16 ], FcepsilonR1 [ 17 , 18 ], TLR3 [ 19 ], NLRP3 [ 20 ], ADAM33 [ 21 ], ADORA1 [ 22 ], ACE [ 23 ], CRTH2 [ 24 ], PPARG [ 25 ], KIF3A [ 26 ], SLC6A12 [ 27 ], SLC22A2 [ 28 ] and CACNG6 [ 29 ]. These findings suggest that additional genetic variation in the extra-arachidonate pathways could be related to the development of AERD.…”