Possible association of oestrogen and Cryba4 with masticatory muscle tendon‐aponeurosis hyperplasia

Hayashi, Naoki; Sato, Tsuyoshi; Kokabu, Shoichiro; Usui, Michihiko; Yumoto, M; Ikami, Eiji; Sakamoto, Yasushi; Nifuji, Akira; Hayata, Tadayoshi; Noda, Masaki; Yoda, Tetsuya

doi:10.1111/odi.12876

Cited by 6 publications

(7 citation statements)

References 37 publications

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“…Our previous study using proteome analysis revealed that beta-crystallin A4, which is increased by tensile force in tenocytes, is up-regulated in patients with MMTAH when compared to patients with facial deformity (FD) (4). Moreover, we showed that tendons in patients with MMTAH abundantly express decorin protein, which was induced by cyclic stretch via yes-associated protein signaling (5). The progression of this disease advances slowly from adolescence.…”

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confidence: 93%

Analysis of Masticatory Muscle Tendon-aponeurosis Hyperplasia by Using Next-generation Sequencing

Yumoto

Mizuno

Isozaki

et al. 2022

In Vivo

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Background/Aim: Masticatory muscle tendonaponeurosis hyperplasia (MMTAH) is a disease associated with a mouth opening limitation. Here, we conducted a bioinformatics analysis to examine gene expression patterns in patients with MMTAH in comparison to those with facial deformity (FD). Materials and Methods: Seven MMTAH patients and three FD patients were recruited. We conducted RNA sequencing analysis, quantitative reverse transcription polymerase chain reaction and immunoblot analysis. Results: Of the identified 19,767 mapped read tags that showed clear differential expression, 2,471 genes were significantly up-regulated and 2,849 genes were significantly down-regulated in patients with MMTAH compared to those in patients with FD. Among the up-regulated genes, ten genes were significantly increased. The distribution of upregulated and down-regulated genes at different ages tended to be similar. Moreover, the protein levels of Ankyrin Repeat Domain 2, Troponin T1 and myosin heavy chain 7, which are associated with slow twitch fibers and mechanical loading, were strongly expressed in patients with MMTAH compared to those in patients with FD. Conclusion: The gene expression pattern in MMTAH patients was similar regardless of age. As the transition of fast-to-slow twitch in the skeletal muscle is induced by mechanical loading, and up-regulation of slow twitch molecules was observed in MMTAH patients, mechanical loading is suggested to be implicated in MMTAH.

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confidence: 93%

Analysis of Masticatory Muscle Tendon-aponeurosis Hyperplasia by Using Next-generation Sequencing

Yumoto

Mizuno

Isozaki

et al. 2022

In Vivo

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“…A physiological dose of estrogen increased the levels of scleraxis and tenomodulin (markers of tendon development) in TT-D6 tenocytes. A mechanical loading assay using tensile force revealed that tensile force increases the Cryba4 levels in tenocytes21. This suggests that mechanical stress may affect tendon differentiation.…”

Section: Etiologymentioning

confidence: 96%

Masticatory muscle tendon-aponeurosis hyperplasia accompanied by limited mouth opening

Yoda

2019

JKAOMS

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Patients with masticatory muscle tendon-aponeurosis hyperplasia (MMTAH) experience limited mouth opening due to restricted muscle extension. Hyperplastic aponeurosis and tendons lead to the restriction of muscle extension. The criteria for the diagnosis of MMTAH are limited mouth opening that progresses very slowly from adolescence, intraoral palpation reveals a hard cord-like structure along the overhang of the anterior border of the masseter muscle on maximum mouth opening, and a square mandible. Conservative treatment, including pharmacotherapy, occlusal splint and physical therapy are ineffective. The standard therapy is surgical treatment, such as anterior partial aponeurectomy of the masseter muscle and coronoidectomy. The long-term results are very satisfying.

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“…Proteomics analysis showed that the pattern of fibrinogen fragment-D, and crystallin CRYBA4 was characteristic in the temporal tendon of patients with MMTAH [ 17 ]. To elucidate the environmental factors of this disease, Hayashi et al [ 18 , 19 ] examined the effect of cyclic stretch on tenocytes and found that the expression of CRYBA4 mRNA was increased and the abundance of the decorin protein was increased via the yes-associated protein. Recently, Ito et al [ 20 ] showed that the response to mechanical stretching stress was different in the temporal tendon and the Achilles tendon.…”

Section: Introductionmentioning

confidence: 99%

“…Acquired factors, such as gliding and clenching, can have the same effect on the masticatory tendons. Indeed, Sato, Yoda, and coworkers [ 17 , 18 , 19 ] demonstrated that the pathogenesis of MMTAH was dependent on environmental factors and that the cyclic strain differentially affected the gene expression in the Achilles tendon and tendons of the masticatory muscles [ 20 ]. Moreover, hyperplasia always develops bilaterally, and MMTAH is more common in women than in men [ 8 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

“…Indeed, Sato, Yoda, and coworkers [ 17 , 18 , 19 ] demonstrated that the pathogenesis of MMTAH was dependent on environmental factors and that the cyclic strain differentially affected the gene expression in the Achilles tendon and tendons of the masticatory muscles [ 20 ]. Moreover, hyperplasia always develops bilaterally, and MMTAH is more common in women than in men [ 8 , 18 ]. Clinical evidence has shown that MMTAH develops from elementary school age and gradually progresses over time [ 8 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

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Genetic Landscape of Masticatory Muscle Tendon–Aponeurosis Hyperplasia

Tajima,

Okazaki,

Sato

et al. 2023

Genes

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Limited mouth opening is a characteristic of masticatory muscle tendon-aponeurosis hyperplasia (MMTAH). Although genetic involvement is suspected where familial onset is frequently observed, the genetic background of MMTAH is yet to be elucidated. In this study, we conducted whole genome sequencing of 10 patients with MMTAH and their family members when available. We also conducted RNA sequencing of normal temporal tendon (as disease region) and Achilles tendon (as control region) from commercially available pig samples. We identified 51 genes that had rare variants in patients with MMTAH and were highly expressed in the temporal tendons of pigs. Among the 51 genes, 37 genes have not been reported to be causative for human genetic diseases so far. As an implication of genetic involvement in the pathogenesis of MMTAH, 21 of these 37 genes were identified in two independent families. In particular, PCDH1 and BAIAP3 were identified in one affected individual in a family and consistently segregated in unrelated family, indicating they could be candidate causative genes of MMTAH. Our findings will help elucidate the genetic landscape of MMTAH and provide insights into future possibilities for tendon regeneration treatment.

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Possible association of oestrogen and Cryba4 with masticatory muscle tendon‐aponeurosis hyperplasia

Abstract: Oestrogen and Cryba4 may be associated with the progression of masticatory muscle tendon-aponeurosis hyperplasia.

Cited by 6 publications

References 37 publications

Analysis of Masticatory Muscle Tendon-aponeurosis Hyperplasia by Using Next-generation Sequencing

Analysis of Masticatory Muscle Tendon-aponeurosis Hyperplasia by Using Next-generation Sequencing

Masticatory muscle tendon-aponeurosis hyperplasia accompanied by limited mouth opening

Genetic Landscape of Masticatory Muscle Tendon–Aponeurosis Hyperplasia

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