Possible association between social cognition and metabolic dysfunctions in Bipolar Disorder and Schizophrenia: Preliminary results

Cigliobianco, Michela; Paoli, R; Caletti, Elisabetta; Mansur, Rodrigo B.; Zugno, Elisa; Prunas, Cecilia; McIntyre, Roger S.

doi:10.1016/j.jad.2018.12.116

Cited by 15 publications

(11 citation statements)

References 107 publications

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“…First, there was heterogeneity across studies with respect to patient and illness characteristics, comorbidity, stage of illness, and treatment. For example, it has been shown that metabolic comorbidity, which is known to affect individuals with BD differentially, may be associated with a greater deficit in measures of social cognition 56 . However, in the risk of bias assessment, the majority of these potential confounders were assessed and found to be controlled for.…”

Section: Discussionmentioning

confidence: 99%

“…For example, it has been shown that metabolic comorbidity, which is known to affect individuals with BD differentially, may be associated with a greater deficit in measures of social cognition. 56 However, in the risk of bias assessment, the majority of these potential confounders were assessed and found to be controlled for. There was also heterogeneity concerning the measurement of social cognition.…”

Section: Limitationsmentioning

confidence: 99%

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Deficits of social cognition in bipolar disorder: Systematic review and meta‐analysis

et al. 2021

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Background The association between impaired social cognition and bipolar disorder (BD) is well established. However, to our knowledge, there has not been a recent systematic review that characterizes disparate dimensions of social cognition in BD. Herein, this systematic review and meta‐analysis aimed to synthesize the literature on core aspects of social cognition (i.e., Theory of Mind, emotion recognition, and social judgment) to identify potential areas of impairment. Methods Online databases (i.e., PubMed, Cochrane Libraries, PsycINFO) and Google Scholar were searched from inception to May 2021. Studies with populations ages ≥16 with DSM‐IV or DSM‐5 defined BD (I or II) either in a euthymic or symptomatic state were included. The risk of bias was measured using the ROBINS‐1 tool, and the quality of the sources was evaluated using GRADE criteria. The results of the studies were quantitatively measured by synthesizing Hedge's g effect sizes through a random effects meta‐analytic approach. Results A total of 29 studies were included in the final review (i.e., 12 studies on the Theory of Mind, 11 on emotion recognition, and 6 on social judgment). Overall, results demonstrated social cognition to be moderately impaired in individuals with BD (d = 0.59). The individual domains ranged in effect size (0.38 < d < 0.70), providing evidence for variation in impairment within social cognition. Discussion Individuals with BD exhibit clinically significant deficits in social cognition during euthymic and symptomatic states. Social cognition impairments in individuals with BD are an important therapeutic target for treatment discovery and development.

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Section: Discussionmentioning

confidence: 99%

Section: Limitationsmentioning

confidence: 99%

Deficits of social cognition in bipolar disorder: Systematic review and meta‐analysis

et al. 2021

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“…A similar relationship of personality characteristics and eating behavior is found in SMDs [39][40][41]. Furthermore, recent studies of SMDs indicate a relationship between cognitive functioning and BMI or waist circumference [42][43][44][45]. Impaired cognitive function also appears to be related to childhood trauma in the same disorders [46,47].…”

Section: Introductionmentioning

confidence: 54%

Childhood trauma and cardiometabolic risk in severe mental disorders: The mediating role of cognitive control

et al. 2021

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Background Cardiometabolic risk is increased in severe mental disorders (SMDs), and there appears to be a relationship between childhood trauma and cardiometabolic risk, possibly related to adverse health behavior. The current study examined the association between childhood trauma and serum lipids and adiposity in SMDs and the potential mediating role of cognitive and personality characteristics. Methods Participants with schizophrenia and bipolar spectrum disorders (N = 819) were included, cardiometabolic risk factors (serum lipids, body mass index, and waist circumference) were measured, and history of childhood trauma was assessed by the Childhood Trauma Questionnaire. Cognitive and personality characteristics were available in subsamples, with assessments of cognitive control, impulsiveness, self-esteem, and affective lability. Linear regressions and mediation analyses with Hayes’ PROCESS were performed, adjusting for age, sex, antipsychotic agent propensity of metabolic side-effect, and diagnostic group. Results Experience of three or more subtypes of childhood trauma was positively associated with waist circumference in patients with SMDs (p = 0.014). There were no other significant associations between trauma variables and lipid or adiposity measures in the total sample. Cognitive control was a significant mediator between experience of one or two subtypes of childhood trauma and waist circumference. Conclusions The results indicate childhood trauma as a predisposing factor for increased waist circumference in individuals with SMDs. Poorer cognitive control, suggestive of adverse health behavior, might be a mediating factor of the association, and the findings indicate the potential importance of increased focus on these factors in prevention and treatment regimens targeting cardiometabolic health.

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“…Additionally, neurobiological circuits of phenotypical traits (impulsivity) have been postulated to regulate food intake and body mass index (BMI), assembling a complex relation between psychiatric disorders and metabolism. In this sense, patients with obesity could demonstrate disruptive feeding behavior that leads to physical and functional impairment in diseases like bipolar disorder [10], schizophrenia [11], and attention-deficit/hyperactivity disorder (ADHD) [12].…”

Section: Introductionmentioning

confidence: 99%

Psychiatric Comorbidity in Mexican Adolescents with a Diagnosis of Eating Disorders Its Relationship with the Body Mass Index

Ruíz-Ramos

Martínez‐Magaña

García

et al. 2021

IJERPH

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The prevalence of comorbid psychiatric disorders among patients with eating disorders (ED) is higher than the general population. Individuals diagnosed with eating disorders have changes in their body mass index which could promote severe metabolic disruptions. This study aimed (1) to report the prevalence of comorbid psychiatric disorders among a Mexican adolescent sample diagnosed with eating disorders, (2) to compare our results with the prevalence of psychiatric disorders reported from a national survey of mental health of adolescents, (3) to compare the presence of psychiatric comorbidities between ED diagnoses, and (4) to explore the relationship of these comorbidities with the body mass index. In the study, we included 187 Mexican adolescents diagnosed with eating disorders. The psychiatric comorbidities were evaluated using the Mini International Neuropsychiatric Interview for children/adolescents, and a revised questionnaire on eating and weight patterns. We found that 89% of the Mexican adolescents diagnosed with ED had another psychiatric comorbidity. Major depressive disorder (52.40%) and suicide risk (40%) were the most prevalent comorbidities. Attention and deficit hyperactivity disorder (ADHD) prevalence was different between ED diagnosis, and adolescents with binge-eating disorder and ADHD had the higher body mass index. Our results showed that in this sample of Mexican adolescents, the presence of comorbidities could impact body mass index. This emphasizes the importance that clinicians take into consideration the presence of psychiatric comorbidities to achieve an integrative treatment for adolescents diagnosed with ED.

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Possible association between social cognition and metabolic dysfunctions in Bipolar Disorder and Schizophrenia: Preliminary results

Cited by 15 publications

References 107 publications

Deficits of social cognition in bipolar disorder: Systematic review and meta‐analysis

Deficits of social cognition in bipolar disorder: Systematic review and meta‐analysis

Childhood trauma and cardiometabolic risk in severe mental disorders: The mediating role of cognitive control

Psychiatric Comorbidity in Mexican Adolescents with a Diagnosis of Eating Disorders Its Relationship with the Body Mass Index

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