Possible Association Between Leukemia in Children and Virus-Like Agents

Mycoplasmal Infections Prevent Apoptosis and Induce Malignant Transformation of Interleukin-3-Dependent 32D Hematopoietic Cells

“…It is important to note that previous studies reported isolation of mycoplasmas from human leukemic bone marrow (1,7,10,14,21). A majority of the mycoplasma population isolated was identified as Mycoplasma fermentans.…”

Mycoplasma fermentans infection promotes immortalization of human peripheral blood mononuclear cells in culture

“…[7][8][9][10][11] A majority of the isolated mycoplasmas were identified as Mycoplasma fermentans. Experimental inoculation of M fermentans induced leukemoid disease with myeloproliferative changes in mice.…”

A colour test for the measurement of antibody to certain mycoplasma species based upon the inhibition of acid production

“…In this connexion, the occurrence of antibody to M. fermentans in 13-5 % of adult sera diluted 1/5 is of interest since reports of the isolation of this mycoplasma species from man are few (Huijsmans-Evers & Ruys, 1956;Ruiter & Wentholt, 1953). Recently, 'virus-like' particles associated with human leukaemic bone marrow (Murphy, Furtado & Plata, 1965) have been identified as M. fermentans in this laboratory. In addition to M. fermentans and the Negroni agent, other acid-producing mycoplasmas have been recovered recently in association with human leukaemia and human tumours (Mittelman, Horoszewicz & Grace, 1965).…”