Possible association between delusional disorder, somatic type and reduced regional cerebral blood flow

Wada, Tadashi; Kawakatsu, Shinobu; Komatani, A; Okuyama, Naoki; Otani, Koichi

doi:10.1016/s0278-5846(98)00098-0

Cited by 22 publications

(26 citation statements)

References 2 publications

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“…This hypoperfusion was normalized after resolution of the delusion. Therefore, the previous finding that DDST was associated with hypoperfusion in these brain regions (Wada et al, 1999a) was replicated.…”

Section: Discussionmentioning

confidence: 69%

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Paroxetine treatment of delusional disorder, somatic type

Hayashi

Oshino

Ishikawa

et al. 2004

Human Psychopharmacology

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A 77-year-old female showed delusion of infestation in the oral cavity. She was treated by paroxetine 20 mg/day, and the hypochondriacal delusion disappeared after 8 weeks. Hypoperfusion in the left temporal and parietal lobes which was observed when she had the delusion was normalized after resolution of the delusion. This report suggests that paroxetine may be effective for delusional disorder, somatic type. It also supports the previous views that this disorder is associated with serotonergic dysfunction and hypoperfusion in the temporal and parietal lobes.

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Section: Discussionmentioning

confidence: 69%

“…Meanwhile, Wada et al (1999a) reported on a patient with DDST whose hypoperfusion in the temporal and parietal lobes improved in parallel with clinical improvement. This report suggests that DDST has some association with hypoperfusion in these brain regions.…”

Section: Introductionmentioning

confidence: 99%

Paroxetine treatment of delusional disorder, somatic type

Hayashi

Oshino

Ishikawa

et al. 2004

Human Psychopharmacology

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“…Clomipramine was shown to improve a DD somatic-type in a 17-year-old outpatient 33 , who was reported to present dysthymic mood, and in a 78-year-old female patient admitted to a psychiatric ward 6 .…”

Section: Resultsmentioning

confidence: 95%

“…Several hypotheses have been reported when focusing on the therapeutic efficacy of antidepressants in DD. Wada and colleagues 6 suggest a serotonergic dysfunction in DD, specifically in those with a DD somatic type.…”

Section: Discussionmentioning

confidence: 99%

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Delusional disorder: an overview of affective symptoms and antidepressant use

et al. 2013

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-Background and Objectives:In clinical practice, the coexistence of delusions and affective symptoms is often observed. The current Diagnostic and Statistical Manual of Mental Disorders, fourth edition-Text Revision (DSM-IV-TR) accepts the existence of mood disturbances in delusional disorder. Little research has been done regarding this field and prevalence rates are unclear. Our purpose was to review the frequency of affective symptoms in delusional disorder patients and to identify the proportion of these patients that are reported to be treated with antidepressants.Methods: Three electronic databases were searched from 1980 to July 2012: MED-LINE, PsycINFO and PubMed, using the following keywords: delusional disorder, depression, affective illness, antidepressants and paranoia.Results: A high frequency of affective disturbances was found in this population (21-55.8%). In contrast, a low antidepressants prescription rate was shown. When focusing on delusional disorder somatic subtype, a particularly high mood disorder comorbidity rate was described and a good efficacy of antidepressant drugs was reported, in monotherapy or in combination with antipsychotics. ALEXANDRE GONZÁLEZ-RODRÍGUEZ ET AL. Background and objectives

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Brain perfusion asymmetry in patients with oral somatic delusions

Umezaki

Katagiri

Watanabe

et al. 2013

Eur Arch Psychiatry Clin Neurosci

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Oral cenesthopathy is a somatic delusion or hallucination involving the oral area and is categorized as a delusional disorder, somatic type. The pathophysiology of this intractable condition remains obscure. In this study, we clarified the pathophysiology of oral cenesthopathy by evaluating regional brain perfusion. We performed single photon emission computed tomography (SPECT) using 99mTc-ethylcysteinate dimer in 16 subjects (cenesthopathy:control = 8:8). The SPECT images were visually assessed qualitatively, and quantitative analyses were also performed using a three-dimensional stereotactic region-of-interest template. The visual assessment revealed a right > left perfusion asymmetry in broad areas of the brain among the patients. The quantitative analysis confirmed that the regional cerebral blood flow values on the right side were significantly larger than those on the left side for most areas of the brain in the patients. A comparison of the R/(R + L) ratios in both groups confirmed the significant brain perfusion asymmetry between the two sides in the callosomarginal, precentral, and temporal regions in the patients. Qualitative evaluation of the SPECT images revealed right > left brain perfusion asymmetry in broad regions of the brain. Moreover, the quantitative analyses confirmed the perfusion asymmetry between the two sides in the frontal and temporal areas. Those may provide the key for elucidation of the pathophysiology of oral cenesthopathy.

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Possible association between delusional disorder, somatic type and reduced regional cerebral blood flow

Cited by 22 publications

References 2 publications

Paroxetine treatment of delusional disorder, somatic type

Paroxetine treatment of delusional disorder, somatic type

Delusional disorder: an overview of affective symptoms and antidepressant use

Brain perfusion asymmetry in patients with oral somatic delusions

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