Possible amotivational effects following marijuana smoking under laboratory conditions.

Cherek, Don R.; Lane, Scott D.; Dougherty, Donald M.

doi:10.1037/1064-1297.10.1.26

Cited by 37 publications

(31 citation statements)

References 39 publications

(48 reference statements)

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“…Laboratory data indicate that THC acutely affects behavioral disengagement (e.g., Cherek, et al, 2002), which may be particularly likely in a distressing task if the task is lacking in personal relevance. Personal salience on task performance was evident when financial incentive attenuated amotivational effects (e.g., Cherek et al, 2002). Similarly, persistence in a physically distressing task (e.g., cold-pressor task) is longer when individuals are asked to utilize values-based imagery to increase personal salience for enduring acute pain, relative to a control group without personalized component (Branstetter-Rost, Cushing, & Douleh, 2009).…”

Section: Discussionmentioning

confidence: 99%

Acute effects of cannabis on breath-holding duration.

Farris¹,

Metrik

2016

Experimental and Clinical Psychopharmacology

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Distress intolerance (an individual’s perceived or actual inability to tolerate distressing psychological or physiological states) is associated with cannabis use. It is unknown whether a bio-behavioral index of distress intolerance, breath-holding duration, is acutely influenced (increased or decreased) by cannabis. Such information may further inform understanding of the expression of psychological or physiological distress post-cannabis use. This within-subjects study examined whether smoked marijuana with 2.7–3.0 % delta-9-tetrahydrocannabinol (THC), relative to placebo, acutely changed duration of breath-holding. Participants (n = 88; 65.9% male) were non-treatment seeking frequent cannabis users who smoked placebo or active THC cigarette on two separate study days and completed breath-holding task. Controlling for baseline breath-holding duration and participant sex, THC produced significantly lower breath-holding durations relative to placebo. There was a significant interaction of drug administration x frequency of cannabis use, such that THC decreased breath-holding time among less frequent but not among more frequent users. Findings indicate that cannabis may be exacerbating distress intolerance (via breath-holding duration). As compared to less frequent cannabis users, frequent users display tolerance to cannabis’ acute effects including increased ability to tolerate respiratory distress when holding breath. Objective measures of distress intolerance are sensitive to contextual factors such as acute drug intoxication, and may inform the link between cannabis use and the expression of psychological distress.

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Section: Discussionmentioning

confidence: 99%

Acute effects of cannabis on breath-holding duration.

Farris¹,

Metrik

2016

Experimental and Clinical Psychopharmacology

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“…First, preexisting differences in neurocognition, which may increase risk for substance use (Nigg et al, 2004), cannot be ruled out in this cross-sectional study. Second, given the studies suggesting decreased motivation associated with marijuana use (Cherek et al, 2002;Lane et al, 2005), the observed cognitive differences may be due to amotivational influences on test performance. Third, we used composite scores for data reduction purposes, and although common practice, they may not reproduce in other samples.…”

Section: Discussionmentioning

confidence: 99%

Neuropsychological functioning in adolescent marijuana users: Subtle deficits detectable after a month of abstinence

Medina

Hanson

Schweinsburg

et al. 2007

J. Inter. Neuropsych. Soc.

258

259

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In adults, studies examining the long-lasting cognitive effects of marijuana use demonstrate subtle deficits in attention, executive function, and memory. Because neuromaturation continues through adolescence, these results cannot necessarily generalize to adolescent marijuana users. The goal of this study was to examine neuropsychological functioning in abstinent marijuana using and demographically similar control adolescents. Data were collected from 65 adolescent marijuana users (n 5 31, 26% females) and controls (n 5 34, 26% females) 16-18 years of age. Extensive exclusionary criteria included independent psychiatric, medical, and neurologic disorders. Neuropsychological assessments were conducted after . 23 days of monitored abstinence. After controlling for lifetime alcohol use and depressive symptoms, adolescent marijuana users demonstrated slower psychomotor speed ( p , .05), and poorer complex attention ( p , .04), story memory ( p , .04), and planning and sequencing ability ( p , .001) compared with controls. Post hoc analysis revealed that the number of lifetime marijuana use episodes was associated with poorer cognitive function, even after controlling for lifetime alcohol use. The general pattern of results suggested that, even after a month of monitored abstinence, adolescent marijuana users demonstrate subtle neuropsychological deficits compared with nonusers. It is possible that frequent marijuana use during adolescence may negatively influence neuromaturation and cognitive development. (JINS, 2007, 13, 807-820.)

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“…The number of inhalations per dose was recorded and compared across all conditions. Importantly, the current paced, cued smoking procedure has been widely used and produces reliable physiological and subjective effects data indicative of acute marijuana intoxication (Chait, 1989;Cherek et al, 2002;Haney et al, 1997;Lane and Cherek, 2002).…”

mentioning

confidence: 99%

Acute Marijuana Effects on Human Risk Taking

Lane

Cherek

Tcheremissine

et al. 2005

Neuropsychopharmacol

149

100

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Previous studies have established a relationship between marijuana use and risky behavior in natural settings. A limited number of laboratory investigations of marijuana effects on human risk taking have been conducted. The present study was designed to examine the acute effects of smoked marijuana on human risk taking, and to identify behavioral mechanisms that may be involved in drug-induced changes in the probability of risky behavior. Using a laboratory measure of risk taking designed to address acute drug effects, 10 adults were administered placebo cigarettes and three doses of active marijuana cigarettes (half placebo and half 1.77%; 1.77%; and 3.58% D 9 -THC) in a within-subject repeated-measures experimental design. The risk-taking task presented subjects with a choice between two response options operationally defined as risky and nonrisky. Data analyses examined cardiovascular and subjective effects, response rates, distribution of choices between the risky and nonrisky option, and first-order transition probabilities of trial-by-trial data. The 3.58% THC dose increased selection of the risky response option, and uniquely shifted response probabilities following both winning and losing outcomes following selection of the risky option. Acute marijuana administration thereby produced measurable changes in risky decision making under laboratory conditions. Consistent with previous risk-taking studies, shifts in trial-by-trial response probabilities at the highest dose suggested a change in sensitivity to both reinforced and losing risky outcomes. Altered sensitivity to consequences may be a mechanism in drug-induced changes in risk taking. Possible neurobiological sites of action related to THC are discussed. Neuropsychopharmacology (2005) 30, 800-809.

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Possible amotivational effects following marijuana smoking under laboratory conditions.

Cited by 37 publications

References 39 publications

Acute effects of cannabis on breath-holding duration.

Acute effects of cannabis on breath-holding duration.

Neuropsychological functioning in adolescent marijuana users: Subtle deficits detectable after a month of abstinence

Acute Marijuana Effects on Human Risk Taking

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