Possible Amelioration of the Severity of Nutritional Steatohepatitis by Guggulsterone in Mice

Nafeer, Sara Ameen; Zalzala, Munaf H.

doi:10.31351/vol28iss1pp17-23

Cited by 3 publications

(3 citation statements)

References 24 publications

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“…After 8 weeks, all rats were euthanized by diethyl ether [ 24 ]. Euthanasia was performed by cutting the carotid artery, followed by cervical dislocation.…”

Section: Methodsmentioning

confidence: 99%

Potential anti-obesity effects of two-graded doses of Iraqi Hibiscus tiliaceus leaves extract, alone and in combination with orlistat, on high-fat diet-induced obesity in male rats

Mohammed,

Mutlag

2023

JMedLife

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Obesity is a world health concern and a serious risk factor for several chronic diseases. Hibiscus tiliaceus is a plant with reported anti-obesity properties. However, the preclinical anti-obesity effect of ethanolic extract of Iraqi Hibiscus tiliaceus has not been studied yet. This study aimed to evaluate the preclinical anti-obesity properties of Iraqi Hibiscus tiliaceus extract, alone or in combination with orlistat, on high-fat diet-induced obesity in male rats. Male rats were divided into five groups: control, induction, ethanolic extract of Iraqi Hibiscus tiliaceus (250 mg/kg and 500 mg/kg), orlistat (Xenical) alone (10 mg/kg), and a combination of the extract (250 mg/kg) with Xenical. The rats were fed a high-fat diet to induce obesity, and treatments were given orally for 8 weeks. Body weight, food intake, serum lipid profile, and liver enzymes were measured. Administration of ethanolic extract of Iraqi Hibiscus tiliaceus (250 mg/kg and 500 mg/kg), Xenical alone (10 mg/kg), and combination with the extract (250 mg/kg) for 8 weeks significantly reduced body weight, food intake, serum triglycerides, total cholesterol, low-density lipoprotein cholesterol, and liver enzymes (aspartate transaminase and alanine transaminase) when compared to the induction group. The ethanolic extract of Iraqi Hibiscus tiliaceus showed anti-obesity effects and could be a potential therapeutic agent in managing obesity. However, further studies are needed to evaluate its clinical efficacy and safety.

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“…After 8 weeks, all rats were euthanized by diethyl ether [ 24 ]. Euthanasia was performed by cutting the carotid artery, followed by cervical dislocation.…”

Section: Methodsmentioning

confidence: 99%

Potential anti-obesity effects of two-graded doses of Iraqi Hibiscus tiliaceus leaves extract, alone and in combination with orlistat, on high-fat diet-induced obesity in male rats

Mohammed,

Mutlag

2023

JMedLife

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“…These cytokines increase the recruitment of immune cells to the area of inflammation, promote the production of enzymes that degrade joint tissue, and promote the proliferation of synovial cells. These processes contribute to the formation of pannus, exacerbating the influx of immune cells to the site of inflammation and ultimately advancing the progression of various diseases, including non-alcoholic fatty liver disease (NAFLD) and other related conditions [7]. , a cytokine produced by Th17 cells, plays a critical role in the onset of RA [8,9].…”

Section: Introductionmentioning

confidence: 99%

Evaluating the effect of ursodeoxycholic acid (UDCA) in comparison with dexamethasone and diclofenac in a rat model of rheumatoid arthritis

Abduljaleel,

Jwaid,

Hussein

2023

JMedLife

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Ursodeoxycholic acid (UDCA) is known for its major effects on the liver, but its impact on autoimmune diseases is not well understood. This study aimed to assess the effectiveness of UDCA in controlling rheumatoid arthritis (RA) in an in vivo setting. Experimental RA was induced in rats using Freund's complete adjuvant, and the effects of UDCA (50,100 mg/kg) were compared to those of dexamethasone and diclofenac by measuring changes in paw size, IL-17, pro-inflammatory cytokines, oxidative stress (GSH, MDA), and radiological changes. The administration of UDCA resulted in decreased cartilage damage, reduced paw edema, and a decrease in the release of pro-inflammatory cytokines and oxidative stress. Additionally, X-ray joint alterations were observed in the UDCA-treated group compared to the dexamethasone and diclofenac groups. These results suggest that UDCA has anti-rheumatoid arthritis properties due to its ability to minimize oxidative stress and inflammation in arthritis-affected rats.

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“…Insulin resistance is a key component in the onset and progression of NAFLD. It promotes de novo lipogenesis and lipolysis leading to inflammation and change of lipid metabolism which enhances additional insulin resistance leading to excessive amounts of fatty acids in the liver which in turn causes lipotoxicity, which is the primary cause of hepatocyte impairment and pathogenicity of NAFLD (7,8) .…”

Section: Introductionmentioning

confidence: 99%

Therapeutic Effects of Vitamin E in Non-alcoholic Fatty Liver Disease: An Open-Labeled Clinical Trial

Fairooz¹,

Jamal²,

Alkhalidi³

2022

IJPS

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non-alcoholic fatty liver disease (NAFLD) is one of the widespread chronic liver diseases; it is ranging from simple fat buildup in the liver (steatosis) to non-alcoholic steatohepatitis (NASH) presence of inflammation and hepatocyte injury. This study aims to assess the effect of vitamin E on the degree of fatty infiltration in the liver, liver enzymes, and lipid profile. A prospective open-labeled clinical trial involved (39) Participants diagnosed with NAFLD depending on ultrasonography findings, they were administered vitamin E 800IU\day for 12wks and advised to take low fat, low carbohydrate diet and to do regular sport. Steatosis score, liver enzymes, fasting blood sugar and lipid profile were measured at baseline and repeated at 4wks and 12wks of the study period. Results of this study found that vitamin E reduces steatosis score significantly at 12wks (p=0.0001), while liver enzymes ALT and ALP did not show significant difference throughout the study period at 12wks (p=0.081 for ALT, P=0.117 for ALP) only AST showed significant difference ( p=0.008 at 12wks ), total cholesterol and triglyceride were reduced significantly (p=0.0001 for both) at 4wks and 12wks where HDL and fasting blood glucose were not altered significantly through the study period. In conclusion, vitamin E and lifestyle modifications have a positive impact on patients with NAFLD by reducing steatosis score, lipid profile, and BMI

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Possible Amelioration of the Severity of Nutritional Steatohepatitis by Guggulsterone in Mice

Cited by 3 publications

References 24 publications

Potential anti-obesity effects of two-graded doses of Iraqi Hibiscus tiliaceus leaves extract, alone and in combination with orlistat, on high-fat diet-induced obesity in male rats

Potential anti-obesity effects of two-graded doses of Iraqi Hibiscus tiliaceus leaves extract, alone and in combination with orlistat, on high-fat diet-induced obesity in male rats

Evaluating the effect of ursodeoxycholic acid (UDCA) in comparison with dexamethasone and diclofenac in a rat model of rheumatoid arthritis

Therapeutic Effects of Vitamin E in Non-alcoholic Fatty Liver Disease: An Open-Labeled Clinical Trial

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